Patents by Inventor JUNE L. ROUND

JUNE L. ROUND has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VACCINATION AGAINST FUNGAL EPITOPES TO PREVENT INFLAMMATORY BOWEL DISEASES
    Publication number: 20240358804
    Abstract: The invention provides a vaccine against inflammatory bowel disease (IBD), such as Crohn's disease, ulcerative colitis, and the like. The vaccine comprises a polypeptide comprising a Candida adhesin antigen, typically an isolated agglutinin-like sequence (Als) protein antigen, formulated with one or more pharmaceutically acceptable carriers or excipients.
    Type: Application
    Filed: December 27, 2023
    Publication date: October 31, 2024
    Inventors: Ashraf S. IBRAHIM, June L. ROUND, Kyla OST
  • Immunomodulating compounds and related compositions and methods
    Patent number: 11622973
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: April 11, 2023
    Assignees: California Institute of Technology, Brigham and Women's Hospital
    Inventors: Sarkis K. Mazmanian, June L. Round, Ryan Michael O'Connell, Dennis L. Kasper
  • VACCINATION AGAINST FUNGAL EPITOPES TO PREVENT INFLAMMATORY BOWEL DISEASES
    Publication number: 20220354935
    Abstract: The invention provides a vaccine against inflammatory bowel disease (IBD), such as Crohn's disease, ulcerative colitis, and the like. The vaccine comprises a polypeptide comprising a Candida adhesin antigen, typically an isolated agglutinin-like sequence (Als) protein antigen, formulated with one or more pharmaceutically acceptable carriers or excipients.
    Type: Application
    Filed: April 21, 2022
    Publication date: November 10, 2022
    Inventors: Ashraf S. IBRAHIM, June L. ROUND, Kyla OST
  • CLOSTRIDIA CONSORTIA COMPOSITIONS AND METHODS OF TREATING OBESITY, METABOLIC SYNDROME AND IRRITABLE BOWEL DISEASE
    Publication number: 20220265734
    Abstract: Disclosed herein, are compositions comprising a consortium of Clostridia, and methods of treating obesity, metabolic syndrome, irritable bowel disease, as well as reducing weight gain and inhibiting lipid absorption in the small intestine by administering the compositions to a subject.
    Type: Application
    Filed: July 17, 2020
    Publication date: August 25, 2022
    Inventor: June L. Round
  • Sepsis treatment and related compositions methods and systems
    Patent number: 11331335
    Abstract: Provided herein are methods and systems and related compositions comprising an effective amount of one or more zwitterionic polysaccharide possibly in combination with one or more antibiotics, for treatment and/or prevention of sepsis or a condition associated thereto in an individual.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: May 17, 2022
    Assignee: California Institute of Technology
    Inventors: Sarkis K. Mazmanian, June L. Round, Yue Shen
  • Antigen specific Tregs and related compositions, methods and systems
    Patent number: 11103566
    Abstract: Antigen specific regulatory T cells are described and related compositions, methods and systems. Methods to generate an antigen specific anti-inflammatory regulatory T cell is provided, the method comprising contacting either a T cell or an antigen presenting cell with a zwitterionic polysaccharide conjugated to the antigen for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: August 31, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: June L. Round, Sarkis K. Mazmanian
  • Immunomodulating Compounds and Related Compositions and Methods
    Publication number: 20200197436
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: September 5, 2019
    Publication date: June 25, 2020
    Inventors: June L. ROUND, Sarkis K. MAZMANIAN, Ryan Michael O'CONNELL, Dennis L. KASPER
  • IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20190022128
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: October 4, 2018
    Publication date: January 24, 2019
    Inventors: Sarkis K. Mazmanian, June L. Round, Ryan Michael O'Connell, Dennis L. Kasper
  • IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20180264026
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: September 15, 2017
    Publication date: September 20, 2018
    Inventors: June L. ROUND, Sarkis K. MAZMANIAN, Ryan Michael O'CONNELL, Dennis L. KASPER
  • ANTIGEN SPECIFIC TREGS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20180055919
    Abstract: Antigen specific regulatory T cells are described and related compositions, methods and systems. Methods to generate an antigen specific anti-inflammatory regulatory T cell is provided, the method comprising contacting either a T cell or an antigen presenting cell with a zwitterionic polysaccharide conjugated to the antigen for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen.
    Type: Application
    Filed: April 27, 2017
    Publication date: March 1, 2018
    Inventors: June L. ROUND, Sarkis K. MAZMANIAN
  • METHODS AND SYSTEMS FOR IDENTIFYING IMMUNOMODULATORY SUBSTANCES
    Publication number: 20170003274
    Abstract: A method and system is presented for screening bacteria, products purified or made by bacteria and/or other bacterial substance for anti-inflammatory ability.
    Type: Application
    Filed: January 29, 2016
    Publication date: January 5, 2017
    Inventors: June L. ROUND, Yue SHEN, Sarkis K. MAZMANIAN
  • SEPSIS TREATMENT AND RELATED COMPOSITIONS METHODS AND SYSTEMS
    Publication number: 20160361343
    Abstract: Provided herein are methods and systems and related compositions comprising an effective amount of one or more zwitterionic polysaccharide possibly in combination with one or more antibiotics, for treatment and/or prevention of sepsis or a condition associated thereto in an individual.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 15, 2016
    Inventors: Sarkis K. MAZMANIAN, June L. Round, Yue Shen
  • IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20160030464
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: March 17, 2015
    Publication date: February 4, 2016
    Inventors: Sarkis K. MAZMANIAN, June L. ROUND, Ryan Michael O'CONNELL, Dennis L. KASPER
  • IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20160022727
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: February 25, 2015
    Publication date: January 28, 2016
    Inventors: June L. ROUND, Sarkis K. MAZMANIAN, Ryan Michael O'CONNELL, Dennis L. KASPER
  • IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20130039949
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: May 4, 2012
    Publication date: February 14, 2013
    Inventors: Sarkis MAZMANIAN, June L. ROUND, Ryan Michael O'CONNELL, Dennis L. KASPER
  • Antigen Specific Tregs and related compositions, methods and systems
    Publication number: 20110287048
    Abstract: Antigen specific regulatory T cells are described and related compositions, methods and systems. Methods to generate an antigen specific anti-inflammatory regulatory T cell is provided, the method comprising contacting either a T cell or an antigen presenting cell with a zwitterionic polysaccharide conjugated to the antigen for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen.
    Type: Application
    Filed: May 20, 2011
    Publication date: November 24, 2011
    Inventors: June L. Round, Sarkis K. Mazmanian
  • IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20110002965
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 6, 2011
    Inventors: June L. Round, Sarkis Mazmanian, Ryan Michael O'Connell, Dennis L. Kasper
  • METHODS AND SYSTEMS FOR IDENTIFYING IMMUNOMODULATORY SUBSTANCES
    Publication number: 20100275282
    Abstract: A method and system is presented for screening bacteria, products purified or made by bacteria and/or other bacterial substance for anti-inflammatory ability.
    Type: Application
    Filed: April 23, 2010
    Publication date: October 28, 2010
    Inventors: JUNE L. ROUND, YUE SHEN, SARKIS K. MAZMANIAN
  • IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20090124573
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: November 9, 2008
    Publication date: May 14, 2009
    Inventors: SARKIS MAZMANIAN, JUNE L. ROUND, RYAN MICHAEL O'CONNELL, DENNIS L. KASPER