Patents by Inventor Junfang Ji

Junfang Ji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF MiR-26 FAMILY AS A PREDICTIVE MARKER FOR HEPATOCELLULAR CARCINOMA AND RESPONSIVENESS TO THERAPY
    Publication number: 20150329919
    Abstract: Provided is a method of selecting a patient diagnosed with HCC as a candidate for IFN-? therapy, by detecting the level of microRNA-26 expression in a sample obtained from the patient.
    Type: Application
    Filed: August 4, 2015
    Publication date: November 19, 2015
    Applicants: THE OHIO STATE UNIVERSITY, FUDAN UNIVERSITY, The Government of the United States of America as represented by the Secretary of the Department of
    Inventors: Xin W. Wang, Junfang Ji, Carlo M. Croce, Hui-Chuan Sun, Zhao-You Tang
  • Use of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy
    Patent number: 9125923
    Abstract: It is disclosed herein that expression of microRNA-26 is decreased in hepatocellular (HCC) tumor tissue relative to non-cancerous tissue, and that a low level of microRNA-26 is associated with a poor clinical outcome. It is also disclosed herein that a low expression level of microRNA-26 is correlated with a favorable response to interferon (IFN)-? therapy in HCC patients. Thus, provided herein is a method of predicting the clinical outcome of a patient diagnosed with HCC comprising detecting the level of microRNA-26 expression in a sample obtained from the patient. Also provided is a method of selecting a patient diagnosed with HCC as a candidate for IFN-? therapy, comprising detecting the level of microRNA-26 expression in a sample obtained from the patient. A method of identifying therapeutic agents for the treatment of HCC, comprising screening candidate agents in vitro to select an agent that increases expression of microRNA-26 in HCC cells are also provided.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: September 8, 2015
    Assignees: The Ohio State University, Fudan University, The United States of America as Represented by the Secretary of the Dept. of Health and Human Services
    Inventors: Xin W. Wang, Junfang Ji, Carlo M. Croce, Hui-chuan Sun, Zhao-you Tang
  • Method for Determining Hepatocellular Carcinoma Subtype and Detecting Hepatic Cancer Stem Cells
    Publication number: 20140018409
    Abstract: Described herein are methods of determining an HCC subtype in a subject which includes a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. Also described are methods of detecting HCC stem cells in a sample, and methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.
    Type: Application
    Filed: June 12, 2013
    Publication date: January 16, 2014
    Applicants: The Government of the United States of America, as represented by the Secretary of the Department of, The Ohio State University Research Foundation
    Inventors: Xin Wei Wang, Junfang Ji, Taro Yamashita, Carlo M. Croce
  • Methods for determining heptocellular carcinoma subtype and detecting hepatic cancer stem cells
    Patent number: 8465917
    Abstract: The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: June 18, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health, Office of Technology Transfer
    Inventors: Xin Wei Wang, Junfang Ji, Taro Yamashita, Carlo M. Croce
  • Use of MiR-26 Family as a Predictive Marker for Hepatocellular Carcinoma and Responsiveness to Therapy
    Publication number: 20110124521
    Abstract: It is disclosed herein that expression of microRNA-26 is decreased in hepatocellular (HCC) tumor tissue relative to non-cancerous tissue, and that a low level of microRNA-26 is associated with a poor clinical outcome. It is also disclosed herein that a low expression level of microRNA-26 is correlated with a favorable response to interferon (IFN)-? therapy in HCC patients. Thus, provided herein is a method of predicting the clinical outcome of a patient diagnosed with HCC comprising detecting the level of microRNA-26 expression in a sample obtained from the patient. Also provided is a method of selecting a patient diagnosed with HCC as a candidate for IFN-? therapy, comprising detecting the level of microRNA-26 expression in a sample obtained from the patient. A method of identifying therapeutic agents for the treatment of HCC, comprising screening candidate agents in vitro to select an agent that increases expression of microRNA-26 in HCC cells are also provided.
    Type: Application
    Filed: June 11, 2009
    Publication date: May 26, 2011
    Applicants: THE OHIO STATE UNIVERSITY, FUDAN UNIVERSITY, OF HEALTH AND HUMAN SERVICES
    Inventors: Xin W. Wang, Junfang Ji, Carlo M. Croce, Hui-Chuan Sun, Zhao-you Tang
  • Methods for Determining Heptocellular Carcinoma Subtype and Detecting Hepatic Cancer Stem Cells
    Publication number: 20100197770
    Abstract: The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.
    Type: Application
    Filed: June 9, 2008
    Publication date: August 5, 2010
    Applicants: The Government of the USA as represented by the Secretary of Dept. of Health & Human Services, The Ohio State University Research Foundation
    Inventors: Xin Wei Wang, Junfang Ji, Taro Yamashita, Carlo M. Croce