Patents by Inventor Junfei Li
Junfei Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250107807Abstract: An occluder support and a preparation method thereof are disclosed. The occluder support includes a mesh body formed of multiple first struts and a trailing structure connected to a distal end of the mesh body. The trailing structure includes multiple circumferentially arranged second struts each inwardly folded into a blunt shape and brought into contact with a corresponding one of the first struts of the mesh body. Each pair of second and first struts in contact have one or more holes penetrated therethrough and are connected by a suture passing through the one or more holes. The occluder support has a closed proximal end and an open distal end.Type: ApplicationFiled: December 11, 2024Publication date: April 3, 2025Inventors: Yi ZHOU, Zexun ZHU, Ting ZHOU, Huimin CHU, Yao YAO, Zailai JIANG, Junfei LI
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Patent number: 12239324Abstract: A medical instrument (1000) includes a stent (100) and a constraining structure (300). The constraining structure (300) constrains, and thereby prevents tangling of, a trailing section of the stent (100), ensuring successful release of the stent (100). Specifically, the stent (100) has a first proximal end and an opposing first distal end. The first distal end is configured with an expanded configuration and a collapsed configuration. The trailing section at the first distal end includes a number of protrusions (111). The constraining structure (300) includes a body (310) and a clamping mechanism (320). The clamping mechanism (320) is disposed at a distal end of the body (310), and the body (310) extends from the first proximal end to the first distal end. The clamping mechanism (320) limits relative movement and thus prevents tangling of the protrusions (111) by passing through all or some of the protrusions (111).Type: GrantFiled: October 20, 2020Date of Patent: March 4, 2025Assignee: SHANGHAI MICROPORT CARDIOADVENT CO., LTD.Inventors: Yi Zhou, Tianyu Liu, Zexun Zhu, Yao Yao, Junfei Li
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Patent number: 12151070Abstract: Disclosed is a drug eluting balloon for a balloon catheter. The drug eluting balloon comprises a balloon body (100) and a coating (200), and the coating (200) comprises a water-soluble adhesive layer (210), an isolating layer (220) and a drug layer (230) from the inside out. After the drug eluting balloon is pushed to a diseased part, the balloon body (100) is expanded, and the water-soluble adhesive layer (210) dissolves due to scouring by a blood flow, such that the isolating layer (220) and the drug layer (230) are separated from an outer surface of the balloon body (100) and adhere to a blood vessel wall.Type: GrantFiled: October 31, 2019Date of Patent: November 26, 2024Assignee: SHANGHAI MICROPORT MEDICAL (GROUP) CO., LTDInventors: Meng Li, Lu Chen, Junfei Li
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Patent number: 12102328Abstract: A left atrial appendage (LAA) occluder and an LAA occlusion system are disclosed. The LAA occluder enables an increased surgical success rate by allowing repeated good positioning, retrieval and release of the occluder and avoiding the problem of entanglement of the occluding stent during surgery. The LAA occluder includes an occluding stent, a proximal securing member a distal securing member. The occluding stent includes an occlusion structure and a traction structure. The delivery device includes a hollow push tube and a control shaft. The distal securing member can be driven by the control shaft to move toward the proximal securing member until a first distal end of the occlusion structure is in a collapsed configuration, where the distal securing member is blocked from further movement, avoiding the problem of entanglement arising from inward rolling of the occluding stent in the vent of human error.Type: GrantFiled: September 11, 2019Date of Patent: October 1, 2024Assignee: SHANGHAI MICROPORT CARDIOADVENT CO., LTD.Inventors: Yi Zhou, Haiyong Huang, Shaoyang Liu, Yao Yao, Junfei Li
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Publication number: 20240226517Abstract: The present application relates to the field of pharmaceutical technology, in particular, to a drug-loaded medical device, including a medical device body and at least one drug coating, the drug coating is attached to at least one side of a surface of the medical device body. The main component of the drug coating includes a macrolide drug. The drug coating includes elongated prismatic crystals each with at least three lateral edges, and/or the drug coating includes crystal clusters of the elongated prismatic crystals each with at least three lateral edges. An aspect ratio of each elongated prismatic crystal is in a range from 1:1 to 40:1.Type: ApplicationFiled: January 24, 2022Publication date: July 11, 2024Inventors: Meng LI, Qiran DU, Junfei LI
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Publication number: 20240189488Abstract: The present disclosure relates to a medical device. The medical device comprises a matrix and a first coating coated on the matrix. The matrix contains a metal element X having a content of ?5 wt %; the first coating is at least one of an elemental metal layer of the metal element X, an alloy layer of the metal element X, and a metal-ceramic layer of the metal element X; and the first coating does not contain nickel and cobalt. The medical device has good use safety, reliability, and biocompatibility, so that a product can meet a use requirement of large plastic deformation, and has good reliability during use. The medical device can particularly meet requirements of product with large plastic deformation during use, such as medical implant devices.Type: ApplicationFiled: April 7, 2022Publication date: June 13, 2024Inventors: Jiaojiao WANG, Can SUN, Qi ZHOU, Yao YAO, Junfei LI
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Publication number: 20240131311Abstract: The present application relates to the field of pharmaceutical technology, in particular, to a drug-loaded medical device, including a medical device body and at least one drug coating, the drug coating is attached to at least one side of a surface of the medical device body. The main component of the drug coating includes a macrolide drug. The drug coating includes elongated prismatic crystals each with at least three lateral edges, and/or the drug coating includes crystal clusters of the elongated prismatic crystals each with at least three lateral edges. An aspect ratio of each elongated prismatic crystal is in a range from 1:1 to 40:1.Type: ApplicationFiled: January 24, 2022Publication date: April 25, 2024Inventors: Meng LI, Qiran DU, Junfei LI
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Publication number: 20240066617Abstract: A WEDM machine tool for machining a disc-shaped porous part, comprises a workbench, a central stand column, a rotary device, a plurality of wire rack assemblies and a wire feeding mechanism comprising a bottom plate, a wire rack arranged on the bottom plate and a radial driving mechanism for driving the wire rack to move in a radial direction on the bottom plate; and the wire rack is a “[”-shaped rack with an opening oriented to the central stand column; and the wire feeding mechanism comprises a first guide wheel assembly arranged on the workbench to guide an electrode wire into and out of a wire winding barrel, second guide wheel assemblies arranged on the radial driving mechanism and the wire rack, a third guide wheel assembly arranged on the central stand column and a fourth guide wheel assembly arranged between two wire rack assemblies.Type: ApplicationFiled: January 14, 2023Publication date: February 29, 2024Inventors: Guokang SU, Yongjun ZHANG, Zipeng ZHONG, Junfei LI
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Publication number: 20240016500Abstract: A medical system and a medical device. The medical system includes a delivery device and degradable occlude which has a main body, proximal fixing member, distal fixing member, and anchoring portion. The main body has a proximal end connected to the proximal fixing member, and a distal end connected to the distal fixing member. The anchoring portion is defined on the main body. The delivery device includes an external push tube and internal push member. The external push tube is configured to be detachably connected to the proximal fixing member. The internal push member is configured to pass through the external push tube, the proximal fixing member and the main body successively to detachably connect to the distal fixing member. The delivery device is configured to apply an axial pressure to the occluder, to cause the main body to expand from a collapsed configuration to an expanded configuration to drive the anchoring portion to stretch out.Type: ApplicationFiled: August 19, 2021Publication date: January 18, 2024Inventors: Kaibing REN, Zexun ZHU, Tianyu LIU, Yao YAO, Junfei LI
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Publication number: 20240009396Abstract: A drug delivery system includes a medical delivery device, a dispersed substance, a liquid dispersion medium and a balloon catheter. The medical delivery device includes a first housing member, a second housing member and a push mechanism. The first housing member defines a first storage chamber, and the second housing member is disposed over the first housing member and defines a second storage chamber. In a first operational configuration, the first storage chamber is not in communication with the second storage chamber. In a second operational configuration, the first storage chamber is in communication with the second storage chamber, allowing the liquid dispersion medium in the first storage chamber to enter the second storage chamber to be mixed with the dispersed substance to produce a dispersion system. In a third operational configuration, the push mechanism drives the first housing member to move relative to the second housing member.Type: ApplicationFiled: October 28, 2021Publication date: January 11, 2024Inventors: Qiran DU, Meng LI, Junfei LI
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Publication number: 20230270921Abstract: Provided are an implantable medical device (100) and a method for manufacturing the same, and a method for manufacturing a stent. The implantable medical device (100) comprises a metal base (110) and a cladding layer (120). The cladding layer (120) is a nickel-free and cobalt-free metal layer which is deposited on the metal base (110) by means of a metal bond. The arrangement of the cladding layer (120) of the implantable medical device (100) on the metal substrate (110) can prevent carcinogenic elements in the metal base (110) such as nickel and cobalt from dissolution. Moreover, the cladding layer (120) is a nickel-free and cobalt-free metal layer, such that the implantable medical device (100) is free from problems of nickel or cobalt dissolution, thereby improving the biological safety of the implantable medical device (100).Type: ApplicationFiled: June 22, 2021Publication date: August 31, 2023Inventors: Jiaojiao WANG, Xinyu ZHOU, Yao YAO, Qi ZHOU, Junfei LI
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Publication number: 20230256442Abstract: The present disclosure describes systems and methods for versatile acoustic tweezer trapping and transport configurations. Examples can use ultrasound for contact-free, biocompatible, and precise manipulation of particles from millimeter to sub-micrometer scale along a narrow and complex path. Examples include spatially complex particle trapping and manipulation inside a boundary-free chamber using a single pair of sources and a shadow waveguide. The shadow waveguide structure can be disposed just outside a microfluidic chamber to guide and control the acoustic wave fields inside the chamber. The shadow waveguide can create a tightly confined, spatially complex acoustic field inside the chamber without an interior structure that could interfere with net flow or transport.Type: ApplicationFiled: February 17, 2023Publication date: August 17, 2023Inventors: Steven Cummer, Junfei Li, Chen Shen
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DRUG-LOADED MEDICAL DEVICE AND PREPARATION METHOD, DRUG BALLOON, AND DRUG COATING PREPARATION METHOD
Publication number: 20230233742Abstract: A drug-loaded medical device, a preparation method therefor, a drug balloon and a method of preparing a drug coating are disclosed. The medical device or the drug balloon is provided on a surface thereof with a drug coating including a stabilizer and a drug. The stabilizer includes an amphiphilic triblock polymer with hydrophilic segments at both terminals, and the drug coating forms a nano-drug particle suspension in a water-soluble environment. In this way, the prepared nano-drug coating has high drug loading and can deliver the drug in a desirable way. In particular, when it comes into contact with water, the drug can be restored to the original nano size, almost without any particle size increase. This not only avoids the risk of embolism caused by granules, but also enables higher device safety, increased drug uptake and improved therapeutic effects.Type: ApplicationFiled: June 18, 2021Publication date: July 27, 2023Inventors: Meng LI, Yufu WANG, Junfei LI, Yan HU -
Publication number: 20230044992Abstract: Provided are a drug-loaded implantable medical instrument and a manufacturing method therefor. The drug-loaded implantable medical instrument (10) comprises an instrument body (100), a microporous membrane (200) fixed on the instrument body (100), and a nanocrystal medicament (300) loaded on the microporous membrane (200). A method for preparing a drug-loaded implantable medical device includes: providing a microporous membrane; loading a nanocrystalline drug on the microporous membrane; and fixing the microporous membrane loaded with the nanocrystalline drug to the device body.Type: ApplicationFiled: November 25, 2020Publication date: February 9, 2023Inventors: Meng LI, Junfei LI, Yufu WANG
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Patent number: 11575710Abstract: An output-decision-based negative feedback control method and system. The method includes: receiving, by an output decider, output responses of at least two heterogeneous functional equivalents, and dividing numbers corresponding to the at least two heterogeneous functional equivalents into at least one set according to the output responses; determining, by the output decider, credibility of each set according to the output responses, and sending the at least one set and the credibility corresponding to each set to a feedback controller via decision information; generating, by the feedback controller, a first scheduling policy and/or a second scheduling policy according to the decision information; and sending, by the feedback controller, the first scheduling policy to an input proxy, and/or sending a change instruction to the heterogeneous functional equivalent indicated by the second scheduling policy. The method can prevent in advance and process a heterogeneous functional equivalent that may be faulty.Type: GrantFiled: September 1, 2017Date of Patent: February 7, 2023Assignees: SHANGHAI HONGZHEN INFORMATION SCIENCE & TECHNOLOGY, CHINA NATIONAL DIGITAL SWITCHING SYSTEM ENGINEERINInventors: Jiangxing Wu, Lei He, Fan Zhang, Peng Yi, Guozhen Cheng, Yongji Dong, Peijie Li, Junfei Li, Jinling Li, Ting Chen, Ruihao Ding, Quan Ren, Jie Gao
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Patent number: 11547702Abstract: Disclosed is use of amlexanox or a salt thereof or a solvate thereof in preparation of a drug having an inhibitory action on the smooth muscle cells, in particular a drug for preventing and treating vascular restenosis. Further disclosed is a medical device, particularly a drug stent, the surface of which is distributed with amlexanox or the salt thereof or the pharmaceutical composition thereof. Amlexanox has an activity in inhibition of the proliferation of smooth muscle cells, has a low inhibitory property of the endothelial cell growth, is particularly suitable for applying on a medical device to prevent the incidence of vascular restenosis, while not delaying the repair of endothelium.Type: GrantFiled: September 7, 2017Date of Patent: January 10, 2023Assignee: MICROPORT SINICA CO., LTD.Inventors: Lu Chen, Junfei Li, Fei Chen, Xiao Cheng
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Publication number: 20230001058Abstract: A drug-loaded implanted medical device (10) and a preparation method therefor. The drug-loaded implanted medical device (10) comprises a device body (100), a hydrophilic coating layer (200) loaded on the device body (100), and crystalline drug particles (300) loaded on the hydrophilic coating layer (200). The hydrophilic coating layer (200) comprises a graft polymer containing a photo-crosslinked group. The medical device (10) uses a hydrophilic coating layer (200) as a carrier, effectively avoiding the risk of embolism, encouraging the crystalline drug particles to fall off, and helping to achieve a target tissue concentration. The invention can also effectively increase the anchoring effect between the carrier and the device, and reduce toxicity.Type: ApplicationFiled: November 25, 2020Publication date: January 5, 2023Inventors: Meng LI, Junfei LI, Yufu WANG
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Publication number: 20220401112Abstract: A medical instrument (1000) includes a stent (100) and a constraining structure (300). The constraining structure (300) constrains, and thereby prevents tangling of, a trailing section of the stent (100), ensuring successful release of the stent (100). Specifically, the stent (100) has a first proximal end and an opposing first distal end. The first distal end is configured with an expanded configuration and a collapsed configuration. The trailing section at the first distal end includes a number of protrusions (111). The constraining structure (300) includes a body (310) and a clamping mechanism (320). The clamping mechanism (320) is disposed at a distal end of the body (310), and the body (310) extends from the first proximal end to the first distal end. The clamping mechanism (320) limits relative movement and thus prevents tangling of the protrusions (111) by passing through all or some of the protrusions (111).Type: ApplicationFiled: October 20, 2020Publication date: December 22, 2022Inventors: Yi ZHOU, Tianyu LIU, Zexun ZHU, Yao YAO, Junfei LI
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Publication number: 20220288285Abstract: Disclosed are a cationic nanodrug, a preparation method therefor, and a drug-loaded implantable medical device, wherein the cationic nanodrug comprises a vector and a drug loaded on the vector, and the vector comprises one or more of a cationic amphipathic compound and a cationic modifier; the cationic amphipathic compound is a cationic amphipathic compound containing amino and/or acyl; and the cationic modifier is a cationic modifier containing amino and/or acyl. The cationic nanodrug greatly improves the uptake of a drug by cells and has a good slow-release effect.Type: ApplicationFiled: September 1, 2020Publication date: September 15, 2022Inventors: Meng LI, Yufu WANG, Junfei LI
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Publication number: 20220175391Abstract: An occluder support and a preparation method thereof are disclosed. The occluder support includes a mesh body and a trailing structure connected to the mesh body. The trailing structure is inwardly folded into a blunt shape.Type: ApplicationFiled: April 21, 2020Publication date: June 9, 2022Inventors: Yi ZHOU, Zexun ZHU, Ting ZHOU, Huimin CHU, Yao YAO, Zailai JIANG, Junfei LI