Abstract: The invention discloses a (9?-H)-pimarane skeleton diterpenoids with anti-colon cancer activity and a derivative thereof, and further discloses a preparation method and application of the compounds above; the invention finds that novel skeleton compounds 1 and 2 have certain inhibition effects on colon cancer cells, wherein the compound 2 has remarkable anti-proliferation effects on two colon cancer cell lines HT-29 and SW620, and the effects are both stronger than those of a positive drug 5-fluorouracil, so that the compound has the potential of being developed into a new anti-colon cancer drug.

Abstract: Disclosed are two compounds with a new skeleton of ursane triterpenoid—ent-kaurane diterpenoid dimer and a preparation method thereof. According to the invention, chemical ingredients of a tuber of a West African plant I. trichantha are deeply studied, and separated to obtain two compounds Bisicacinol B (1) and Bisicacinol C (2), and the compounds are both a natural hybrid dimer formed by a DielsAlder addition or Michael addition reaction between a ursane triterpenoid with a unique spiro structure and an ent-kaurane diterpenoid. Pharmaceutical experiments show that the Bisicacinol B (1) and Bisicacinol C (2) prepared by the invention have a significant anti-tumor activity (on a pancreatic cancer, a colon cancer, a lung cancer, or a liver cancer), and can also be combined with an amphotericin B to exert a coordinated and synergistic anti-Candida albicans activity.

Abstract: The invention belongs to the field of medicine, and particularly discloses an anti-Helicobacter pylori derivative containing a dihydrostilbene parent nucleus and a preparation method thereof; according to the invention, glycyrrhiza stems and leaves are used as raw materials, subjected to alcohol extraction, and then extracted, separated and identified through a macroporous resin, silica gel column chromatography and a preparative liquid phase to obtain a new natural isopentenyl dihydrostilbene compound, and the new compound has good activity to two kinds of drug-resistant and sensitive Helicobacter pylori, and can be used for preparing an anti-Helicobacter pylori drug.

Abstract: The invention discloses a (9?-H)-pimarane skeleton diterpenoids with anti-colon cancer activity and a derivative thereof, and further discloses a preparation method and application of the compounds above; the invention finds that novel skeleton compounds 1 and 2 have certain inhibition effects on colon cancer cells, wherein the compound 2 has remarkable anti-proliferation effects on two colon cancer cell lines HT-29 and SW620, and the effects are both stronger than those of a positive drug 5-fluorouracil, so that the compound has the potential of being developed into a new anti-colon cancer drug.