Patents by Inventor JUNFEN XU

JUNFEN XU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN OVARIAN CANCER NIRAPARIB-RESISTANT CELL STRAIN AND USE THEREOF
    Publication number: 20240263142
    Abstract: A human ovarian cancer Niraparib-resistant cell strain and use thereof provided. A human ovarian cancer A2780 cell strain is selected as parental cell, and A2780-NiraR (preservation number: CCTCC NO: C202299) drug-resistant cell strain is established by gradually increasing concentration of PARP inhibitor Niraparib from 2 ?M to 40 ?M. Resistance index to Niraparib of A2780-NiraR is 8.274. In addition to resistance to Niraparib, A2780-NiraR cells are cross-resistant to Taxol. Moreover, the drug resistance of A2780-NiraR cell strain is re-tested as more than 90% of original after 3-month drug-withdrawal culture and 6-month liquid nitrogen cryopreservation and resuscitation following establishment, showing an excellent drug resistance stability. It can be used to study the tumor drug resistance mechanisms, analyze the susceptibility of chemotherapeutic drugs, screen and evaluate chemotherapeutic drugs, develop drug resistance reversal agents, and research more effective tumor treatment methods.
    Type: Application
    Filed: April 3, 2024
    Publication date: August 8, 2024
    Inventors: Weiguo LU, Hui LIN, Yuqing SHEN, Junfen XU
  • Methods for the detection of cervical cancer and cervical intraepithelial neoplasia
    Patent number: 11905564
    Abstract: Described herein are biomarkers for HPV-associated pre-cancers and cancers such as cervical cancer and cervical intraepithelial neoplasia. The RNA binding protein (RBP) and long-noncoding RNA (lnc-RNA) biomarkers can be detected and used to diagnose HPV-associated pre-cancers and cancers. In addition, early diagnosis of HPV-associated pre-cancers and cancers can facilitate therapeutic intervention in patients, particularly in the pre-cancer stage which can delay or prevent progression to cancer.
    Type: Grant
    Filed: August 1, 2022
    Date of Patent: February 20, 2024
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Zhi-Ming Zheng, Junfen Xu, Jun Zhu, Yanqin Yang, Xiaohong Wang
  • Compositions and Methods for the Detection and Treatment of Cervical Cancer and Cervical Intraepithelial Neoplasia
    Publication number: 20230122007
    Abstract: Described herein are biomarkers for HPV-associated pre-cancers and cancers such as cervical cancer and cervical intraepithelial neoplasia. The RNA binding protein (RBP) and long-noncoding RNA (lnc-RNA) biomarkers can be detected and used to diagnose HPV-associated pre-cancers and cancers. In addition, early diagnosis of HPV-associated pre-cancers and cancers can facilitate therapeutic intervention in patients, particularly in the pre-cancer stage which can delay or prevent progression to cancer.
    Type: Application
    Filed: August 1, 2022
    Publication date: April 20, 2023
    Inventors: Zhi-Ming Zheng, Junfen Xu, Jun Zhu, Yanqin Yang, Xiaohong Wang
  • COMPOSITIONS AND METHODS FOR THE DETECTION AND TREATMENT OF CERVICAL CANCER AND CERVICAL INTRAEPITHELIAL NEOPLASIA
    Publication number: 20200032352
    Abstract: Described herein are biomarkers for HPV-associated pre-cancers and cancers such as cervical cancer and cervical intraepithelial neoplasia. The RNA binding protein (RBP) and long-noncoding RNA (lnc-RNA) biomarkers can be detected and used to diagnose HPV-associated pre-cancers and cancers. In addition, early diagnosis of HPV-associated pre-cancers and cancers can facilitate therapeutic intervention in patients, particularly in the pre-cancer stage which can delay or prevent progression to cancer.
    Type: Application
    Filed: October 8, 2019
    Publication date: January 30, 2020
    Inventors: ZHI-MING ZHENG, JUNFEN XU, JUN ZHU, YANQIN YANG, XIAOHONG WANG
  • Methods for detecting expression of lnc-FANCI-2 in cervical cells
    Patent number: 10487365
    Abstract: Described herein are biomarkers for HPV-associated pre-cancers and cancers such as cervical cancer and cervical intraepithelial neoplasia. The RNA binding protein (RBP) and long-noncoding RNA (lnc-RNA) biomarkers can be detected and used to diagnose HPV-associated pre-cancers and cancers. In addition, early diagnosis of HPV-associated pre-cancers and cancers can facilitate therapeutic intervention in patients, particularly in the pre-cancer stage which can delay or prevent progression to cancer.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: November 26, 2019
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Zhi-Ming Zheng, Junfen Xu, Jun Zhu, Yanqin Yang, Xiaohong Wang
  • COMPOSITIONS AND METHODS FOR THE DETECTION AND TREATMENT OF CERVICAL CANCER AND CERVICAL INTRAEPITHELIAL NEOPLASIA
    Publication number: 20180080084
    Abstract: Described herein are biomarkers for HPV-associated pre-cancers and cancers such as cervical cancer and cervical intraepithelial neoplasia. The RNA binding protein (RBP) and long-noncoding RNA (lnc-RNA) biomarkers can be detected and used to diagnose HPV-associated pre-cancers and cancers. In addition, early diagnosis of HPV-associated pre-cancers and cancers can facilitate therapeutic intervention in patients, particularly in the pre-cancer stage which can delay or prevent progression to cancer.
    Type: Application
    Filed: September 20, 2016
    Publication date: March 22, 2018
    Inventors: ZHI-MING ZHENG, JUNFEN XU, JUN ZHU, YANQIN YANG, XIAOHONG WANG