Abstract: A method for determining phase locking of critical arc light includes: step 1: monitoring and collecting light radiation intensity of an arc inside a switch cabinet in real time, and converting the collected light radiation intensity into an electrical signal; step 2: extracting a power-frequency fundamental wave of the electrical signal, comparing an amplitude of the power-frequency fundamental wave of the electrical signal with a first threshold, and generating a pre-warning signal based on a comparison result of the first threshold; step 3: comparing the amplitude of the power-frequency fundamental wave of the electrical signal with a second threshold voltage, and generating a control signal based on a comparison result of the second threshold voltage and a protection time threshold; and step 4: protecting the switch cabinet under the critical arc light environment based on the pre-warning signal and the control signal.

Abstract: Provided are methods for expanding tumor-infiltrating lymphocytes (TILs), which include co-culturing an initial cell population containing TILs with first feeder cells to obtain a first expanded cell population; and then co-culturing the first expanded cell population with second feeder cells to obtain an expanded TIL population. The methods can quickly produce a large number of TILs from a small tumor sample.

Abstract: The present disclosure provides methods for improving the preparation efficiency of genetically modified immune cells and improving the quality of immune cells.

Abstract: A ligand screening model construction method, a ligand screening model construction device, and a drug ligand screening method for drug screening, comprising that obtain a drug ligand training set, and the drug ligand training set includes a drug ligand chemical formula and a classification label; a ligand graph network is drawn, in which atoms are nodes and chemical bonds are edges connecting nodes; use a random initialization vector to identify the weight vector of each node in the ligand graph network; reconstruct each node of the ligand graph network to obtain a reconstruction network, and repeat the reconstruction steps to obtain at least two layers of reconstruction networks; perform deep learning on the ligand graph network and the at least two-layer reconstruction graph network according to the classification labels, and construct a ligand screening model.

Abstract: A PROTAC target molecule generation method, system, and storage medium where the method includes obtaining parameters; extract the target protein ligand structure corresponding to the first parameter in the target protein ligand database to form a first subset, extract the degradation agent fragment structure corresponding to the parameter in the degradation agent fragment database to form a second subset, and extract the linker fragment structure corresponding to the parameter in the linker fragment database to form a third subset; permute and combine each fragment structure in the subsets to generate PROTAC target molecules. The extract required fragment structures from various databases, then permute and combine the three groups of fragment structure, and use big data and computational processing to be used for experiments, avoids the omission of the combination of structural fragments, improves the accuracy of molecular design and speeds up drug research and development processes.

Abstract: A partial discharge (PD) detection apparatus for gas-insulated equipment includes a photon collector, an optical splitter, a first photoelectric conversion module, an ultraviolet fluorescent crystal, a second photoelectric conversion module, and a signal processing module, where the ultraviolet fluorescent crystal is configured to convert a second optical radiation signal into an optical radiation signal of an ultraviolet fluorescence band, and the signal processing module is configured to calculate first apparent intensity based on a first voltage signal output by the first photoelectric conversion module, calculate second apparent intensity based on a second voltage signal output by the second photoelectric conversion module, and determine discharge intensity of the optical radiation based on a ratio of the second apparent intensity to the first apparent intensity. Technical solutions of the present disclosure are not affected by an unknown distance between a discharge position and a detection point.

Abstract: Methods for preparation of immune cells in a fully closed system are provided. Specifically, the methods contain the steps of pretreating, cell sorting, activation, transduction and expansion. The present methods greatly improve the preparation efficiency of immune cells, and reduce preparation costs.

Abstract: The present disclosure provides systems, kits and methods for determining the copy number of a mouse TCR transgene. The primers are specific to the conserved regions of the mouse TCR gene. The primers/probes provide good amplification efficiency and can quickly and accurately determine the copy number of a mouse TCR transgene.

Abstract: A method for determining phase locking of critical arc light includes: step 1: monitoring and collecting light radiation intensity of an arc inside a switch cabinet in real time, and converting the collected light radiation intensity into an electrical signal; step 2: extracting a power-frequency fundamental wave of the electrical signal, comparing an amplitude of the power-frequency fundamental wave of the electrical signal with a first threshold, and generating a pre-warning signal based on a comparison result of the first threshold; step 3: comparing the amplitude of the power-frequency fundamental wave of the electrical signal with a second threshold voltage, and generating a control signal based on a comparison result of the second threshold voltage and a protection time threshold; and step 4: protecting the switch cabinet under the critical arc light environment based on the pre-warning signal and the control signal.

Abstract: Compositions and methods for the preservation and long-term storage of viral vectors such as lentiviral vectors are provided.

Abstract: A heat dissipation system for a high-speed train running in a low-vacuum tube is provided. Component groups that provide power and resistance for the movement and stop of a train are provided at a periphery, close to the train, in a low-vacuum tube. The component group is provided with a group A cooling assembly. The group A cooling assembly includes a group A cooling-type heat exchanger and/or a group A nozzle assembly attached to the back of the component group. Since the friction between the train running at high speed and the air in the low-vacuum tube and the operation of the key equipment in the low-vacuum tube will generate a lot of heat, the group A cooling assembly in the component group in the low-vacuum tube exchanges the heat with the air in the low-vacuum tube.

Abstract: A partial discharge (PD) detection apparatus for gas-insulated equipment includes a photon collector, an optical splitter, a first photoelectric conversion module, an ultraviolet fluorescent crystal, a second photoelectric conversion module, and a signal processing module, where the ultraviolet fluorescent crystal is configured to convert a second optical radiation signal into an optical radiation signal of an ultraviolet fluorescence band, and the signal processing module is configured to calculate first apparent intensity based on a first voltage signal output by the first photoelectric conversion module, calculate second apparent intensity based on a second voltage signal output by the second photoelectric conversion module, and determine discharge intensity of the optical radiation based on a ratio of the second apparent intensity to the first apparent intensity. Technical solutions of the present disclosure are not affected by an unknown distance between a discharge position and a detection point.

Abstract: The present disclosure discloses a semiconductor device, a method of manufacturing the same, and a semiconductor package structure. The semiconductor device including a substrate, a multilayer semiconductor layer located on one side of the substrate, in which a Two-Dimensional Electron Gas is formed, a first source, a first gate and a first drain located on one side of the multilayer semiconductor layer and located within an active region of the multilayer semiconductor layer, the first gate being located between the first source and the first drain, and a back surface gate contact electrode located on one side of the substrate away from the multilayer semiconductor layer, wherein the first gate is electrically connected to the back surface gate contact electrode. A signal is provided from the back surface of the semiconductor device to the first gate, to reduce the parasitic inductance and parasitic resistance caused by the device during the packaging process.

Abstract: In a general aspect, a target is localized based on measurements from a measurement device array. In some aspects, range difference values (di) and coordinate vectors (ai) of devices in the measurement device array are obtained. The range difference values are generated based on time difference of arrival measurements of wireless signals between the target device and each of the devices in the measurement device array. A first matrix (A) and a first vector (b) are constructed. The first matrix (A) and the first vector (b) each includes the range difference values and the coordinate vectors. Whether a second vector (y) satisfies a condition set is determined. The condition set includes a first condition (ATA+?D)y=ATb and a second condition vT (ATA+?D)v?0. A numerical approximation of an optimal solution of the second vector is generated. The target device is localized according to the numerical approximation of the optimal solution.

Abstract: The invention discloses a method of realizing accelerated parallel Jacobi computing for an FPGA. Data of a n×n-dimensional matrix are input to the FPGA, and a rotation transformation process is carried out by using parallel Jacobi computing. Processors are initialized. A diagonal processor computes a symbol set corresponding to a rotation angle and outputs the symbol set to a non-diagonal processor. Elements of the diagonal processor are updated. Elements of the non-diagonal processor are updated. Elements between the processors are exchanged. After the elements of the respective processors are updated, the updated elements between the processors are exchanged. The invention requires less FPGA resources while yields a higher internal computational processing performance of the FPGA. Accordingly, the invention is capable of facilitating the efficiency of realizing eigenvalue decomposition in the FPGA and is highly applicable in actual processing.

Abstract: A method and a device for controlling a remotely controlled mobile platform and a readable storage medium are provided. The method includes: displaying at least one function icon and at least one control icon, where the function icon represents a control program for implementing a preset function, and the control icon is used to control a control terminal and/or a remotely controlled mobile platform to execute the control program; generating, based on a selection operation of a user on the function icon, the control program associated with the selected function icon; and controlling, based on an operation of the user on the control icon, the control terminal and/or the remotely controlled mobile platform to execute the control program.

Abstract: In a general aspect, a target is localized based on measurements from a measurement device array. In some aspects, range difference values (di) and coordinate vectors (ai) of devices in the measurement device array are obtained. The range difference values are generated based on time difference of arrival measurements of wireless signals between the target device and each of the devices in the measurement device array. A first matrix (A) and a first vector (b) are constructed. The first matrix (A) and the first vector (b) each includes the range difference values and the coordinate vectors. Whether a second vector (y) satisfies a condition set is determined. The condition set includes a first condition (ATA+?D)y=ATb and a second condition vT (ATA+?D)v?0. A numerical approximation of an optimal solution of the second vector is generated.

Abstract: Provided is a method of preparing chimeric antigen receptor T cells by serum-free culture. The method comprises steps of: (a) providing PBMC cells; (b) performing negative sorting treatment on the PBMC cells to obtain sorted PBMC cells; (c) activating the sorted PBMC cells to obtain activated T cells; (d) transfecting the activated T cells with a viral vector expressing a chimeric antigen receptor, so as to obtain transfected T cells; (e) removing the viruses from the transfected T cells to obtain virus-removed T cells; and (f) subjecting the virus-removed T cells to expansion culture to obtain chimeric antigen receptor T cells.