Abstract: A PROTAC target molecule generation method, system, and storage medium where the method includes obtaining parameters; extract the target protein ligand structure corresponding to the first parameter in the target protein ligand database to form a first subset, extract the degradation agent fragment structure corresponding to the parameter in the degradation agent fragment database to form a second subset, and extract the linker fragment structure corresponding to the parameter in the linker fragment database to form a third subset; permute and combine each fragment structure in the subsets to generate PROTAC target molecules. The extract required fragment structures from various databases, then permute and combine the three groups of fragment structure, and use big data and computational processing to be used for experiments, avoids the omission of the combination of structural fragments, improves the accuracy of molecular design and speeds up drug research and development processes.

Abstract: The present disclosure provides systems, kits and methods for determining the copy number of a mouse TCR transgene. The primers are specific to the conserved regions of the mouse TCR gene. The primers/probes provide good amplification efficiency and can quickly and accurately determine the copy number of a mouse TCR transgene.

Abstract: A ligand screening model construction method, a ligand screening model construction device, and a drug ligand screening method for drug screening, comprising that obtain a drug ligand training set, and the drug ligand training set includes a drug ligand chemical formula and a classification label; a ligand graph network is drawn, in which atoms are nodes and chemical bonds are edges connecting nodes; use a random initialization vector to identify the weight vector of each node in the ligand graph network; reconstruct each node of the ligand graph network to obtain a reconstruction network, and repeat the reconstruction steps to obtain at least two layers of reconstruction networks; perform deep learning on the ligand graph network and the at least two-layer reconstruction graph network according to the classification labels, and construct a ligand screening model.

Abstract: The present invention relates to the technical field of surface strengthening for sports equipment, and specifically to a method for multi-field coupling strengthening of an ice skate blade edge. The method includes the following steps: adjusting the laser head so that the laser beam covers the top surface and chamfer of the ice skate blade edge; adjusting the ultrasonic rolling device so that the rolling heads are positioned on both sides of the ice skate blade edge; determining the required laser energy and rolling force according to the material properties of the ice skate blade edge; simultaneously performing laser shock peening and dual-side opposing ultrasonic rolling on the side surfaces of the ice skate blade edge. By combining laser shock peening on the top surface of the blade edge with dual-side opposing ultrasonic rolling, deformation and delamination can be avoided.

Abstract: Embodiments of the present disclosure provide a method, device, and medium for training a large scale object foundation model. The method comprises obtaining a training dataset comprising a plurality of subsets for a plurality of object perception tasks, wherein a sample in the training dataset comprises an image with an object, a prompt indicating the object, and labeled object perception information of the image. The method further comprises generating, by the image encoder, an image feature based on the image. The method further comprises generating, by the text encoder or the visual prompt encoder, a prompt embedding based on the prompt. The method further comprises generating, by the object decoder, object perception information of the object based on the image feature and the prompt embedding. In addition, the method further comprises training the object processing model based on the generated object perception information and the labeled object perception information.

Abstract: According to embodiments of the disclosure, a method, system, device, medium and product for video processing are provided. The method includes extracting a plurality of feature maps from a plurality of frames of a video respectively; determining a plurality of frame-level features of a video instance in the plurality of frames based on the plurality of feature maps respectively, a frame-level feature in each of the frames representing feature information of the video instance in the frame; determining a video-level feature of the video instance by aggregating the plurality of frame-level features, the video-level feature representing feature information of the video instance across the plurality of frames; and determining an analysis result for the video instance in the plurality of frames based at least on the video-level feature.

Abstract: Provided is a preservation solution for low-temperature preservation of adipose-derived mesenchymal stem cells. The preservation solution contains a compound electrolyte injection, a glucose and sodium chloride injection, vitamins, and amino acids. The preservation solution can be used for preserving adipose-derived mesenchymal stem cells at a low temperature, so as to effectively maintain the viability of adipose-derived mesenchymal stem cells, and meet clinical requirements.

Abstract: The present disclosure discloses a semiconductor device, a method of manufacturing the same, and a semiconductor package structure. The semiconductor device including a substrate, a multilayer semiconductor layer located on one side of the substrate, in which a Two-Dimensional Electron Gas is formed, a first source, a first gate and a first drain located on one side of the multilayer semiconductor layer and located within an active region of the multilayer semiconductor layer, the first gate being located between the first source and the first drain, and a back surface gate contact electrode located on one side of the substrate away from the multilayer semiconductor layer, wherein the first gate is electrically connected to the back surface gate contact electrode. A signal is provided from the back surface of the semiconductor device to the first gate, to reduce the parasitic inductance and parasitic resistance caused by the device during the packaging process.

Abstract: A protein virtual screening method and device, equipment, and a storage medium, falling within the field of drug discovery. The method comprises: acquiring a training sample set, wherein the set comprises source and sample data corresponding to the source data; performing unsupervised pre-training on a Transformer model with the source data as input and the sample data as verification, and generating a one-dimensional or multi-dimensional symmetric matrix for the protein sequence and the ligand sequence; coupling two matrices for the protein sequence and the ligand sequence into a multi-dimensional symmetric matrix, and using the matrix as an input of an hidden layer of a BILSTM network model; fitting the experimental measurement classification and regression value of protein and small molecule interaction by the Bilstm network model to obtain to a trained screening model; and predicting different protein prediction tasks by the screening model to output prediction results.

Abstract: According to embodiments of the disclosure, a method, system, device, medium and product for video processing are provided. The method includes extracting a plurality of feature maps from a plurality of frames of a video respectively; determining a plurality of frame-level features of a video instance in the plurality of frames based on the plurality of feature maps respectively, a frame-level feature in each of the frames representing feature information of the video instance in the frame; determining a video-level feature of the video instance by aggregating the plurality of frame-level features, the video-level feature representing feature information of the video instance across the plurality of frames; and determining an analysis result for the video instance in the plurality of frames based at least on the video-level feature.

Abstract: A method, device, and medium for tracking a target object in a video based on an instance motion are provided. In one method, for a set of previous frames prior to a target frame in the video, a set of previous positions of the target object in the set of previous frames is obtained respectively. Based on the set of previous positions, a predicted value of a position of the target object in the target frame is determined with a motion model. A measured value of a position of an object in the target frame is determined. Based on a similarity between the predicted value and the measured value, the target object is tracked in the video.

Abstract: A heat dissipation system for a high-speed train running in a low-vacuum tube is provided. Component groups that provide power and resistance for the movement and stop of a train are provided at a periphery, close to the train, in a low-vacuum tube. The component group is provided with a group A cooling assembly. The group A cooling assembly includes a group A cooling-type heat exchanger and/or a group A nozzle assembly attached to the back of the component group. Since the friction between the train running at high speed and the air in the low-vacuum tube and the operation of the key equipment in the low-vacuum tube will generate a lot of heat, the group A cooling assembly in the component group in the low-vacuum tube exchanges the heat with the air in the low-vacuum tube.

Abstract: A method for determining phase locking of critical arc light includes: step 1: monitoring and collecting light radiation intensity of an arc inside a switch cabinet in real time, and converting the collected light radiation intensity into an electrical signal; step 2: extracting a power-frequency fundamental wave of the electrical signal, comparing an amplitude of the power-frequency fundamental wave of the electrical signal with a first threshold, and generating a pre-warning signal based on a comparison result of the first threshold; step 3: comparing the amplitude of the power-frequency fundamental wave of the electrical signal with a second threshold voltage, and generating a control signal based on a comparison result of the second threshold voltage and a protection time threshold; and step 4: protecting the switch cabinet under the critical arc light environment based on the pre-warning signal and the control signal.

Abstract: Provided are methods for expanding tumor-infiltrating lymphocytes (TILs), which include co-culturing an initial cell population containing TILs with first feeder cells to obtain a first expanded cell population; and then co-culturing the first expanded cell population with second feeder cells to obtain an expanded TIL population. The methods can quickly produce a large number of TILs from a small tumor sample.

Abstract: The present disclosure provides methods for improving the preparation efficiency of genetically modified immune cells and improving the quality of immune cells.

Abstract: A ligand screening model construction method, a ligand screening model construction device, and a drug ligand screening method for drug screening, comprising that obtain a drug ligand training set, and the drug ligand training set includes a drug ligand chemical formula and a classification label; a ligand graph network is drawn, in which atoms are nodes and chemical bonds are edges connecting nodes; use a random initialization vector to identify the weight vector of each node in the ligand graph network; reconstruct each node of the ligand graph network to obtain a reconstruction network, and repeat the reconstruction steps to obtain at least two layers of reconstruction networks; perform deep learning on the ligand graph network and the at least two-layer reconstruction graph network according to the classification labels, and construct a ligand screening model.

Abstract: A PROTAC target molecule generation method, system, and storage medium where the method includes obtaining parameters; extract the target protein ligand structure corresponding to the first parameter in the target protein ligand database to form a first subset, extract the degradation agent fragment structure corresponding to the parameter in the degradation agent fragment database to form a second subset, and extract the linker fragment structure corresponding to the parameter in the linker fragment database to form a third subset; permute and combine each fragment structure in the subsets to generate PROTAC target molecules. The extract required fragment structures from various databases, then permute and combine the three groups of fragment structure, and use big data and computational processing to be used for experiments, avoids the omission of the combination of structural fragments, improves the accuracy of molecular design and speeds up drug research and development processes.

Abstract: A partial discharge (PD) detection apparatus for gas-insulated equipment includes a photon collector, an optical splitter, a first photoelectric conversion module, an ultraviolet fluorescent crystal, a second photoelectric conversion module, and a signal processing module, where the ultraviolet fluorescent crystal is configured to convert a second optical radiation signal into an optical radiation signal of an ultraviolet fluorescence band, and the signal processing module is configured to calculate first apparent intensity based on a first voltage signal output by the first photoelectric conversion module, calculate second apparent intensity based on a second voltage signal output by the second photoelectric conversion module, and determine discharge intensity of the optical radiation based on a ratio of the second apparent intensity to the first apparent intensity. Technical solutions of the present disclosure are not affected by an unknown distance between a discharge position and a detection point.