Patents by Inventor Jung-Chi LIAO

Jung-Chi LIAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12366742
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Grant
    Filed: September 8, 2023
    Date of Patent: July 22, 2025
    Assignee: Academia Sinica
    Inventors: Jung-Chi Liao, Yi-De Chen, Chih-Wei Chang, Weng Man Chong
  • Publication number: 20250052993
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Application
    Filed: October 22, 2024
    Publication date: February 13, 2025
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG
  • Publication number: 20250035910
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Application
    Filed: October 17, 2024
    Publication date: January 30, 2025
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG
  • Publication number: 20250028163
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Application
    Filed: October 8, 2024
    Publication date: January 23, 2025
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG
  • Publication number: 20250028162
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Application
    Filed: October 8, 2024
    Publication date: January 23, 2025
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG
  • Publication number: 20240411122
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Application
    Filed: August 21, 2024
    Publication date: December 12, 2024
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG
  • Publication number: 20240287589
    Abstract: Compositions including photoreactive and cleavable probes and methods of using the probes. The probes may include a tag conjugatable to a label, a cleavable linker linkable to a bait molecule, and a light activated warhead, which may be configured to covalently bond an anchoring strand to a probing strand upon application of light energy. The compositions and methods may be useful for analyzing biomolecules, such as identifying proximal molecules in cell or tissue samples.
    Type: Application
    Filed: March 20, 2024
    Publication date: August 29, 2024
    Inventors: Chih-Wei CHANG, Hsiang-Ju KAI, Chia-Wen CHUNG, Yi-De CHEN, Jung-Chi LIAO
  • Publication number: 20240219705
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Application
    Filed: March 18, 2024
    Publication date: July 4, 2024
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG
  • Publication number: 20240219704
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Application
    Filed: March 18, 2024
    Publication date: July 4, 2024
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG
  • Publication number: 20240219703
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Application
    Filed: March 18, 2024
    Publication date: July 4, 2024
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG
  • Publication number: 20240142440
    Abstract: This disclosure provides photosensitive probes useful for photoactivated and tagging of subsets of biomolecules. These photosensitive probes described herein may be especially useful for selectively tagging and proximity labeling of biomolecules via selective light illumination through a microscope system. The methods and compositions may be particularly useful for analyzing biological samples, such as identifying proximal biomolecules in cell or tissue samples.
    Type: Application
    Filed: October 16, 2023
    Publication date: May 2, 2024
    Inventors: Hsiao-Jen CHANG, Jung-Chi LIAO
  • Publication number: 20230418041
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Application
    Filed: September 8, 2023
    Publication date: December 28, 2023
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG
  • Patent number: 11789251
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Grant
    Filed: February 3, 2022
    Date of Patent: October 17, 2023
    Assignee: Academia Sinica
    Inventors: Jung-Chi Liao, Yi-De Chen, Chih-Wei Chang, Weng Man Chong
  • Publication number: 20230176063
    Abstract: Compositions including photoreactive and cleavable probes and methods of using the probes. The probes may include a tag conjugatable to a label, a cleavable linker linkable to a bait molecule, and a light activated warhead. The compositions and methods may be useful for analyzing biomolecules.
    Type: Application
    Filed: March 19, 2021
    Publication date: June 8, 2023
    Inventors: Chih-Wei CHANG, Yi-De CHEN, Jung-Chi LIAO
  • Publication number: 20220226378
    Abstract: Provided herein are methods for treating or ameliorating malignant diseases, such as cancers. Also provided herein are methods of increasing the immunity of an immune cell toward malignant cells.
    Type: Application
    Filed: January 19, 2022
    Publication date: July 21, 2022
    Inventors: Hsing-Chen Tsai, Chien-Ting Lin, Chong-Jen Yu, Tai-Chung Huang, Rueyhung Roc Weng, Hsuan-Hsuan Lu, Jung-Chi Liao
  • Publication number: 20220159157
    Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
    Type: Application
    Filed: February 3, 2022
    Publication date: May 19, 2022
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG
  • Patent number: 11265449
    Abstract: A microscope-based system and a method for image-guided microscopic illumination are provided. The microscope-based system for image-guided microscopic illumination comprises a microscope, an illuminating assembly, an imaging assembly, a first processing module, and a second processing module. The microscope comprises a stage, and the stage is configured to be loaded with a sample. The imaging assembly comprises a camera. The processing modules are coupled to the microscope, the imaging assembly, and the illuminating assembly.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: March 1, 2022
    Assignee: ACADEMIA SINICA
    Inventors: Jung-Chi Liao, Yi-De Chen, Chih-Wei Chang, Weng Man Chong
  • Publication number: 20180367717
    Abstract: A microscope-based system and a method for image-guided microscopic illumination are provided. The microscope-based system for image-guided microscopic illumination comprises a microscope, an illuminating assembly, an imaging assembly, a first processing module, and a second processing module. The microscope comprises a stage, and the stage is configured to be loaded with a sample. The imaging assembly comprises a camera. The processing modules are coupled to the microscope, the imaging assembly, and the illuminating assembly.
    Type: Application
    Filed: June 20, 2018
    Publication date: December 20, 2018
    Inventors: Jung-Chi LIAO, Yi-De CHEN, Chih-Wei CHANG, Weng Man CHONG