Abstract: A whitlockite preparation method includes: determining a size of the whitlockite crystal to be prepared; determining a first amount of a first cation other than calcium ion on the basis of the determined size of the crystal, wherein when the determined size of the whitlockite crystal is a first size, the first amount is determined to be a first value, wherein when the determined size is a second size larger than the first size, the first amount is determined to be a second value; mixing calcium ion and phosphate ion in order to prepare a first phosphate crystal, wherein the determined first amount of the cation other than calcium ion is also mixed therewith; mixing a second amount of cation other than calcium ion with phosphate ion to prepare a second phosphate crystal; and aging a solution containing the first phosphate crystal and the second phosphate crystal.

Abstract: Disclosed are a composition for surface modification of a medical implant and a medical implant surface-modified thereby, and according to a medical implant according to one embodiment, itaconic acid may be bound to the surface of the medical implant with high binding stability, and fibrosis inhibition and inflammatory response inhibition effects at an implantation site are exhibited.

Abstract: Disclosed is a method for determining malignant melanoma by a scanning probe microscope system with a cantilever, which includes: setting locations of a plurality of measurement points to be measured in a sample tissue; applying force in a predetermined range to each measurement point on the sample tissue through the cantilever and acquiring information on a distance between a probe and the sample tissue depending on force for each measurement point; generating a force-distance graph of measurement points based on distance information depending on the force acquired at the plurality of measurement points; and determining whether the sample tissue is malignant melanoma based on characteristics information of the sample tissue extracted from the force-distance graph.