Abstract: The present disclosure relates to a multi-stage compression system in which the drive speed of each compressor that constitutes the multi-stage compression system is individually controlled to increase compression efficiency, and a control method thereof. To this end, the present disclosure includes at least two compressors, at least two driving devices connected to each of the compressors in series to drive the compressors connected in series, at least two pressure detectors installed at a discharge end of each of the compressors to detect a discharge pressure of each compressor, and a control unit configured to individually control a drive speed of each driving device based on the discharge pressure of each compressor detected through each of the pressure detectors.