Abstract: The present invention relates to a retinol-loaded microneedle. The retinol-loaded microneedle according to the present invention contains retinol and a stabilizer therefor, which is an optimal combination for use in microneedles, in order to solve the instability of retinol. Accordingly, the retinol-loaded microneedle of the present invention achieves high transdermal delivery efficiency intrinsic for microneedle formulations and thus can maximize the effect of retinol on wrinkle reduction, etc.

Abstract: The present disclosure relates to an electrochemical device that can simultaneously satisfy a high energy density of 400 Wh/kg or more, excellent lifespan characteristics, and stability. The electrochemical device according to the present disclosure includes a cathode; an anode including an anode current collector, or the anode current collector and lithium metal; and an electrolyte; wherein the cathode includes a cathode current collector; and a cathode active material layer formed on the cathode current collector, and including a porous binder scaffold and cathode active material particles.

Abstract: Provided are a method and apparatus for providing a counseling service. A method of operating a counseling center server interworking with an instant messaging service includes acquiring, based a search request for a message transmitted to a channel registered in the service, a search result of a chatbot server linked to the channel, providing an interface for inputting a value of at least one parameter included in the search result to a terminal of a counselor linked to the channel, acquiring an entity corresponding to the parameter based on the message, determining a value of the parameter based on at least one of the acquired entity and data input through the interface, and requesting, based on the determined value of the parameter, an instant messaging server configured to provide the service to transmit a response message corresponding to the search result.

Abstract: A map generation method including receiving a map editing request for a specific floor among a plurality of floors of a building, providing an editing interface on a display unit of an electronic device in response to the map editing request, the editing interface including at least a part of a specific map corresponding to the specific floor, specifying at least one node group allocatable on the specific map based on first node rules, the first node rules corresponding to spatial characteristics of the specific floor, and performing a node placement process such that first nodes included among the at least one node group are placed on the specific map.

Abstract: A cover type touch switch structure includes: a seat housing embedded in a seat of a vehicle so as to be fastened to a seat frame; a switch housing disposed in the seat housing and including an outer surface which is coupled to the seat housing via a hook; a light-emitting unit which is disposed in the switch housing and stacked on the seat frame; and a knob unit which has a portion disposed in the switch housing and is stacked on the light-emitting unit.

Abstract: Provided are a pixel circuit and a display device having the pixel circuit. The pixel circuit includes an organic light emitting diode, a switching transistor, a storage capacitor, and a driving transistor. The switching transistor is turned off when a scan signal has a first voltage and turned on when the scan signal has a second voltage. The storage capacitor stores a data voltage when the switching transistor is turned on in response to the scan signal. The driving transistor is electrically connected with the organic light emitting diode between a high power supply voltage and a low power supply voltage to provide a driving current to the organic light emitting diode, and includes a first bottom gate electrode that is provided with the first voltage. The driving current corresponds to the data voltage stored in the storage capacitor.

Abstract: A multilayer electronic component includes a body including a capacitance formation portion including a dielectric layer and internal electrodes alternately disposed in a first direction, and a cover portion disposed on both surfaces of the capacitance formation portion opposing each other in the first direction; and an external electrode disposed on the body and connected to the internal electrode, wherein the cover portion includes polydopamine.

Abstract: The present invention relates to novel peptides having anti-inflammatory and tissue regenerative actions and uses thereof.

Abstract: The present invention relates to an Agathobaculum sp. strain having prophylactic or therapeutic effects on autism spectrum disorders, and use thereof. When the intestinal microorganism Agathobaculum sp. strain of the present invention was orally administered to valproic acid (VPA)-induced autism model mice and BTBR autism model mice, the effects of remarkably improving autism spectrum disorders including repetitive behaviors, hyperactivity, social deficiency and cognitive/memory dysfunction of the mice were observed, as compared with a non-treated control. Accordingly, it may be usefully applied to foods, drugs, or feeds for preventing or treating autism spectrum disorders, and thus is very useful in the relevant industries.

Abstract: Provided are an Agathobaculum sp. strain having prophylactic or therapeutic effects on degenerative brain diseases, and use thereof. Since the intestinal microorganism Agathobaculum butyriciproducens SR79 strain of the present invention may have effects of inhibiting neuroinflammation and effects of improving movement regulation and cognitive and memory functions in animal models with degenerative brain diseases such as Parkinson's disease and Alzheimer's disease, the strain may be effectively used in foods, medicines, or feeds for preventing or treating brain diseases including Alzheimer's disease, Parkinson's disease, mild cognitive impairment, etc., and therefore, it is very useful in the relevant industries.

Abstract: The present invention relates to an Agathobaculum sp. strain having prophylactic or therapeutic effects on autism spectrum disorders, and use thereof. When the intestinal microorganism Agathobaculum sp. strain of the present invention was orally administered to valproic acid (VPA)-induced autism model mice and BTBR autism model mice, the effects of remarkably improving autism spectrum disorders including repetitive behaviors, hyperactivity, social deficiency and cognitive/memory dysfunction of the mice were observed, as compared with a non-treated control. Accordingly, it may be usefully applied to foods, drugs, or feeds for preventing or treating autism spectrum disorders, and thus is very useful in the relevant industries.

Abstract: The present invention relates to: a composition comprising a Sicyos angulatus extract or a fraction thereof as an effective ingredient for preventing, alleviating, or treating liver diseases; and a method for preventing or treating liver diseases, comprising a step of administering the composition to a subject suspected of having a liver disease.

Abstract: The present disclosure relates to an Akkermansia muciniphila strain having a prophylactic or therapeutic effect on a degenerative brain disease and uses thereof. Since the Akkermansia muciniphila strain, the intestinal microorganism of the present disclosure, shows an effect of improving movement control and cognitive abilities as well as memory in an animal model having a degenerative brain disease such as Parkinson's disease and Alzheimer's disease, it can be useful in the prevention or treatment of brain diseases including Alzheimer's disease, Parkinson's disease, mild cognitive impairment, etc. In addition, it was confirmed in the present disclosure that compared to the Akkermansia muciniphila strain cultured in a mucin-containing medium, that cultured in a mucin-free medium showed a remarkable effect of improving hyperlipidemia, fatty liver, obesity, and hyperglycemia induced in a mouse model by high-fat diet when administered orally (in vivo).

Abstract: Provided are an Agathobaculum sp. strain having prophylactic or therapeutic effects on degenerative brain diseases, and use thereof. Since the intestinal microorganism Agathobaculum butyriciproducens SR79 strain of the present invention may have effects of inhibiting neuroinflammation and effects of improving movement regulation and cognitive and memory functions in animal models with degenerative brain diseases such as Parkinson's disease and Alzheimer's disease, the strain may be effectively used in foods, medicines, or feeds for preventing or treating brain diseases including Alzheimer's disease, Parkinson's disease, mild cognitive impairment, etc., and therefore, it is very useful in the relevant industries.

Abstract: The present invention relates to: a composition comprising a Sicyos angulatus extract or a fraction thereof as an effective ingredient for preventing, alleviating, or treating liver diseases; and a method for preventing or treating liver diseases, comprising a step of administering the composition to a subject suspected of having a liver disease.