Abstract: A composition may increase a rate of endometrial blood flow and a composition for increasing implantation potential, including botulinum toxin or a salt thereof, and a pharmaceutical composition may preventing or treating subfertility or infertility, including botulinum toxin or a pharmaceutically acceptable salt thereof. Such compositions can increase a rate of endometrial blood flow and improve embryonic implantation potential just by being applied to the endometrium, and thus may be helpful to patients with subfertility or infertility, especially those who have repetitive failures in embryonic implantation. Since the compositions include botulinum toxin which is a substance that has been widely applied to the human body for cosmetic purposes, studies on human toxicity may have a shortened period, and thus the disclosure is very useful in economical and industrial aspects.

Abstract: The presence of diverse human Papillomavirus genotypes in a sample can be detected by 1 cycle of polymerase chain reaction using primers. The primers used in the method are general primers which can bind complementarily to specific nucleic acid sequences of all HPV genotypes related to cervical carcinoma and its pre-stage lesions and can be used to amplify cervical-neoplasia related HPV genotypes including oncogenic high-risk groups and low-risk groups.