Abstract: The present invention relates to a novel heterocyclic compound and a composition, for preventing or treating a cancer, an autoimmune disease, and an inflammatory disease, comprising same. The novel heterocyclic compound of the present invention is a bifunctional compound having a Bruton's tyrosine kinase (BTK) degradation function via a ubiquitin proteasome pathway, and may be utilized as a composition for preventing or treating a cancer, an autoimmune disease, and Parkinson's disease.

Abstract: The present disclosure provides: a compound of a specific chemical structure, having excellent activity with respect to BTK degradation; or a pharmaceutically acceptable salt thereof. The present disclosure also provides a composition comprising the compound or pharmaceutically acceptable salts thereof. The present disclosure also provides are pharmaceutical use for treating or preventing BTK-associated diseases (for example, autoimmune diseases or cancer) of the compound, the salt thereof, and the composition comprising same according to the present disclosure. The present disclosure also provides a method for treating or preventing BTK-associated diseases (for example, autoimmune diseases or cancer), comprising administering, to a subject requiring treatment, an effective amount of the compound, the salt thereof, or the composition comprising same according to the present disclosure.

Abstract: The present invention pertains to a saturated furodioxin derivative compound, and a use thereof as an additive for a secondary battery. More specifically, the present invention pertains to a novel compound and a method for preparing same, an electrolyte additive and a non-aqueous electrolyte composition containing the compound, and a secondary battery (in particular, a lithium-sulfur secondary battery) including the electrolyte composition, wherein the compound has a structure in which a substituent is bonded to a saturated furodioxin backbone. When the compound is contained as an additive in a non-aqueous electrolyte composition for a secondary battery (in a non-aqueous electrolyte composition for a lithium-sulfur secondary battery), the problem that conventional electrolyte compositions have of lithium polysulfide dissolution can be resolved, and high capacity retention rate characteristics can be achieved for various lithium salts.

Abstract: The present invention relates to a novel heterocyclic compound and a composition, for preventing or treating a cancer, an autoimmune disease, and an inflammatory disease, comprising same. The novel heterocyclic compound of the present invention is a bifunctional compound having a Bruton's tyrosine kinase (BTK) degradation function via a ubiquitin proteasome pathway, and may be utilized as a composition for preventing or treating a cancer, an autoimmune disease, and Parkinson's disease.

Abstract: The present disclosure provides a substituted piperidine compound of Chemical Formula 1, or a pharmaceutically acceptable salt thereof having activity of degrading androgen receptor (AR). The present disclosure also provides a composition comprising such a substituted piperidine compound or a pharmaceutically acceptable salt thereof. The present disclosure also provides a medical use of a substituted piperidine compound according to the present disclosure, a salt thereof, and a composition comprising the same for the treatment or prophylaxis of AR-related diseases. The present disclosure also provides a method for treating or preventing an AR-related disease comprising administering to a subject in need thereof an effective amount of a substituted piperidine compound according to the present disclosure, a salt thereof, or a composition comprising the same.

Abstract: The present disclosure provides a substituted piperidine compound of Chemical Formula 1, wherein X is CR3, or a pharmaceutically acceptable salt thereof having activity of degrading androgen receptor (AR). The present disclosure also provides a composition comprising such a substituted piperidine compound or a pharmaceutically acceptable salt thereof. The present disclosure also provides a medical use of a substituted piperidine compound according to the present disclosure, a salt thereof, and a composition comprising the same for the treatment or prophylaxis of AR-related diseases. The present disclosure also provides a method for treating or preventing an AR-related disease comprising administering to a subject in need thereof an effective amount of a substituted piperidine compound according to the present disclosure, a salt thereof, or a composition comprising the same.

Abstract: The present invention relates to a novel heterocyclic compound and a composition, for preventing or treating a cancer, an autoimmune disease, and an inflammatory disease, comprising same. The novel heterocyclic compound of the present invention is a bifunctional compound having a Bruton's tyrosine kinase (BTK) degradation function via a ubiquitin proteasome pathway, and may be utilized as a composition for preventing or treating a cancer, an autoimmune disease, and Parkinson's disease.

Abstract: The present disclosure provides a compound having a specific chemical structure or a pharmaceutically acceptable salt thereof having activity of degrading androgen receptor (AR). The present disclosure also provides a composition comprising such a compound or a pharmaceutically acceptable salt thereof. The present disclosure also provides a medical use of a compound according to the present disclosure, a salt thereof, and a composition comprising the same for the treatment or prophylaxis of AR-related diseases. The present disclosure also provides a method for treating or preventing an AR-related disease comprising administering to a subject in need thereof an effective amount of a compound according to the present disclosure, a salt thereof, or a composition comprising the same.

Abstract: A method for determining the size of a bicuspid annulus of bicuspid, including acquiring an image of the heart including the left ventricle and the aorta; generating a first plane, which includes a line that passes through two base points in the bicuspid of the image of the heart; and generating multiple second planes, which are obtained per each rotation, while rotating the first plane multiple times by a predetermined angle about the line that passes through the two base points; measuring the cross-sectional area of each of at least one of the left ventricle and the aorta, which are formed on the first plane and the multiple second planes; selecting a plane for measuring the size of a bicuspid annulus among the first plane and the multiple second planes based on the measured cross-sectional area; and measuring the size of the bicuspid annulus based on the selected plane.

Abstract: A method for determining the size of a bicuspid annulus of bicuspid, including acquiring an image of the heart including the left ventricle and the aorta; generating a first plane, which includes a line that passes through two base points in the bicuspid of the image of the heart; and generating multiple second planes, which are obtained per each rotation, while rotating the first plane multiple times by a predetermined angle about the line that passes through the two base points; measuring the cross-sectional area of each of at least one of the left ventricle and the aorta, which are formed on the first plane and the multiple second planes; selecting a plane for measuring the size of a bicuspid annulus among the first plane and the multiple second planes based on the measured cross-sectional area; and measuring the size of the bicuspid annulus based on the selected plane.

Abstract: A banking processing method according is performed by a processing logic including an application for banking processing implemented on a user terminal and a computer-readable storage medium. The method comprises the steps of: when the application for banking processing is run, searching a hardware security area of the user terminal and confirming the existence of a certificate for confirming an execution history of the application for banking processing; when the existence of the certificate is confirmed, searching the security area and confirming the existence of a token key for identifying whether login information of the user has been set; when the existence of the token key is not confirmed, setting the login information of the user by providing a membership page for setting the login information of the user; and opening an account according to a request of the user whose login information has been set.

Abstract: The present invention relates to a blood glucose management device capable of generating valid blood glucose data and an operation method therefor, the device compelling the input of state information (e.g., an empty stomach and time information such as two hours postprandial) at the time of blood glucose measurement by a measurer for the acquisition of accurate blood glucose data. The blood glucose management method may comprise the steps of: sensing the connection of a blood glucose meter; outputting to a display unit a state information input window for inputting state information at the time of blood glucose measurement if the connection of the blood glucose meter is sensed; and controlling the blood glucose meter to measure blood glucose if the state information is input.