Patents by Inventor Jung-Rok Lee
Jung-Rok Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220023584Abstract: Provided is an artificial intelligence-based noninvasive brain circuit control therapy system for sleep enhancement, the system including a wearable device including a first wearable member and a second wearable member formed to be wearable on a body of a user, a first sensor unit disposed on the first wearable member to detect an electroencephalogram (EEG), a second sensor unit disposed on the second wearable member to detect a biometric signal different from the EEG, and a stimulation means disposed on the first wearable member to stimulate the brain according to a stimulation signal provided thereto; a learning unit configured to machine-learn a criterion for determination of a sleep stage of the user based on a first sensing signal generated by the first sensor unit and a second sensing signal generated by the second sensor unit; and a determination unit configured to determine a current sleep stage of the user based on the criterion for determination, generate a stimulation signal corresponding to a deteType: ApplicationFiled: November 5, 2019Publication date: January 27, 2022Inventors: Hyang Woon LEE, Je Won KANG, Jung Rok LEE, Sang Beom JUN, Chang Hyeon JI
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Patent number: 10723775Abstract: The present invention relates to a method for purifying darbepoetin alfa by selectively separating only a structural isoform having a high content of sialic acid from a mixture of structural isoforms of darbepoetin alfa having various contents of sialic acid. Since the method of the present invention is a novel method for purifying darbepoetin alfa which can be conveniently and simply produced, it is possible to remarkably increase productivity due to process efficiency improvement, as well as to yield high purity darbepoetin alfa when mass-producing darbepoetin alfa according to the present invention.Type: GrantFiled: November 28, 2014Date of Patent: July 28, 2020Assignee: CJ Healthcare CorporationInventors: Yoon Jung Lee, Kyung Hwa Kim, Yoo Hee Yang, Jung Min Yoo, Se Jun Kim, Ji Hyun Moon, Hoo Keun Oh, Dong Eok Lee, Won Jeong Lee, Jung Rok Lee, Chung Min Lee, Eun Young Choi, Gyong Sik Ha
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Publication number: 20190195868Abstract: Small molecule analytes (less than 1000 Daltons) in a fluid sample are detected using a competitive assay in a magnetic biosensor. The fluid sample is added to a biosensor detection chamber together with detection probes and magnetic tags which bind to the detection probes. The magnetic biosensor is functionalized with a capture probe that shares an epitope with the analytes, and the detection probe is capable of binding the epitope shared by the analytes and the capture probe, so that the presence of the analyte prevents detection probes (and magnetic tags) from binding to the biosensor. By measuring the binding of the magnetic tags to the magnetic biosensor, an amount of analytes in the solution is determined.Type: ApplicationFiled: February 27, 2019Publication date: June 27, 2019Inventors: Tyler O'Brien Shultz, Shan X. Wang, Jung-Rok Lee
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Patent number: 10261076Abstract: Small molecule analytes (less than 1000 Daltons) in a fluid sample are detected using a competitive assay in a magnetic biosensor. The fluid sample is added to a biosensor detection chamber together with detection probes and magnetic tags which bind to the detection probes. The magnetic biosensor is functionalized with a capture probe that shares an epitope with the analytes, and the detection probe is capable of binding the epitope shared by the analytes and the capture probe, so that the presence of the analyte prevents detection probes (and magnetic tags) from binding to the biosensor. By measuring the binding of the magnetic tags to the magnetic biosensor, an amount of analytes in the solution is determined.Type: GrantFiled: September 30, 2016Date of Patent: April 16, 2019Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Tyler O'Brien Shultz, Jung-Rok Lee, Shan X. Wang
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Publication number: 20180312911Abstract: A method of methylation detection provides a quantitative description of the methylation density in DNA strands. Bisulphite conversion [100] of the DNA strands containing methylated and unmethylated sites creates converted DNA strands with mismatch base pairs. The converted DNA strands are PCR amplified [102], and single strand target DNA strands are magnetically labeled [104] and hybridized [106] with complementary DNA strands immobilized onto a magnetoresistive (MR) sensor array. During hybridization, a binding signal may be recorded. A stringency condition such as temperature or salt concentration is increased [108] to cause the magnetically labeled single strand target DNA strands to be denatured from the complementary DNA strands immobilized onto a magnetoresistive (MR) sensor array.Type: ApplicationFiled: May 1, 2018Publication date: November 1, 2018Inventors: Jung-Rok Lee, Shan X. Wang, Mikkel F. Hansen, Martin Dufva, Giovanni Rizzi
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Publication number: 20170097337Abstract: Small molecule analytes (less than 1000 Daltons) in a fluid sample are detected using a competitive assay in a magnetic biosensor. The fluid sample is added to a biosensor detection chamber together with detection probes and magnetic tags which bind to the detection probes. The magnetic biosensor is functionalized with a capture probe that shares an epitope with the analytes, and the detection probe is capable of binding the epitope shared by the analytes and the capture probe, so that the presence of the analyte prevents detection probes (and magnetic tags) from binding to the biosensor. By measuring the binding of the magnetic tags to the magnetic biosensor, an amount of analytes in the solution is determined.Type: ApplicationFiled: September 30, 2016Publication date: April 6, 2017Inventors: Tyler O'Brien Shultz, Jung-Rok Lee, Shan X. Wang
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Publication number: 20170022257Abstract: The present invention relates to a method for purifying darbepoetin alfa by selectively separating only a structural isoform having a high content of sialic acid from a mixture of structural isoforms of darbepoetin alfa having various contents of sialic acid. Since the method of the present invention is a novel method for purifying darbepoetin alfa which can be conveniently and simply produced, it is possible to remarkably increase productivity due to process efficiency improvement, as well as to yield high purity darbepoetin alfa when mass-producing darbepoetin alfa according to the present invention.Type: ApplicationFiled: November 28, 2014Publication date: January 26, 2017Inventors: Yoon Jung Lee, Kyung Hwa Kim, Yoo Hee Yang, Jung Min Yoo, Se Jun Kim, Ji Hyun Moon, Hoo Keun Oh, Dong Eok Lee, Won Jeong Lee, Jung Rok Lee, Chung Min Lee, Eun Young Choi, Gyong Sik Ha
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Patent number: 8673653Abstract: Provided is a novel method for amplifying mass spectrometric signals. A novel method for detecting signals of a target molecule includes: allowing a sample, which comprises a target molecule, to contact a gold particle having a surface modified to selectively bind the target molecule, allowing a low molecular weight molecule engrafted to the gold particle generate mass spectrometric signals after the interaction, e.g., binding, between the gold particle and the target molecule, and amplifying the mass spectrometric signals to generate much mass spectrometric signals of the low molecular weight molecule even when trace amounts of the target molecule are present. An assay system using the method and the gold particle prepared in the method are provided. The method amplifies signals of the target molecule without pretreatment of a sample, making it possible to measure the target molecule simply and precisely.Type: GrantFiled: April 10, 2009Date of Patent: March 18, 2014Assignee: Diatech Korea Co., Ltd.Inventors: Hyung-Soon Park, Sang-Wan So, Woon-Seok Yeo, Soo-Jae Lee, Jung-Rok Lee, Ju-Hee o Lee, Kwang-Pyo Kim
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Publication number: 20110053292Abstract: There is provided a novel method for amplifying mass spectrometric signals. More particularly, a novel method for detecting signals of a target molecule includes: i) allowing a test sample, in which it is required to determine whether or not a target molecule is present, to be contact with a gold particle whose surface is modified to selectively bind to the target molecule, ii) allowing a low molecular molecule engrafted to the gold particle to generate mass spectrometric signals after the interaction, such as binding, between the gold particle and the target molecule, and iii) amplifying the mass spectrometric signals by generating a great deal of mass spectrometric signals of the low molecular molecule even in the presence of a trace of the target molecule. Also, the assay system using the method and the gold particle prepared in the method are provided.Type: ApplicationFiled: April 10, 2009Publication date: March 3, 2011Applicant: PROBIOND CO., LTD.Inventors: Hyung-Soon Park, Sang-Wan So, Woon-Seok Yeo, Soo-Jae Lee, Jung-Rok Lee, Ju-Hee Lee, Kwang-Pyo Kim
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Patent number: 7644447Abstract: Provided is a scanning probe microscope capable of precisely analyzing characteristics of samples having an overhang surface structure. The scanning probe microscope comprises a first probe, a first scanner changing a position of the first probe along a straight line, and a second scanner changing a position of a sample in a plane, wherein the straight line in which the position of the first probe is changed by using the first scanner is non-perpendicular to the plane in which the position of the sample is changed by using the second scanner.Type: GrantFiled: November 17, 2006Date of Patent: January 5, 2010Assignee: Park Systems Corp.Inventors: Sang-il Park, Yong-Seok Kim, Jitae Kim, Sang Han Chung, Hyun-Seung Shin, Jung-Rok Lee, Euichul Hwang
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Publication number: 20090200462Abstract: A scanning probe microscope tilts the scanning direction of a z-scanner by a precise amount and with high repeatability using a movable assembly that rotates the scanning direction of the z-scanner with respect to the sample plane. The movable assembly is moved along a curved guide and has grooves that engage with corresponding projections on a stationary frame to precisely position the movable assembly at predefined locations along the curved guide.Type: ApplicationFiled: February 26, 2009Publication date: August 13, 2009Applicant: Park Systems Corp.Inventors: Sang-il PARK, Yong-Seok KIM, Jitae KIM, Sang Han CHUNG, Hyun-Seung SHIN, Jung-Rok LEE, Euichul HWANG
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Publication number: 20080078932Abstract: Provided is a scanning probe microscope capable of precisely analyzing characteristics of samples having an overhang surface structure. The scanning probe microscope comprises a first probe, a first scanner changing a position of the first probe along a straight line, and a second scanner changing a position of a sample in a plane, wherein the straight line in which the position of the first probe is changed by using the first scanner is non-perpendicular to the plane in which the position of the sample is changed by using the second scanner.Type: ApplicationFiled: November 17, 2006Publication date: April 3, 2008Inventors: Sang-il Park, Yong-Seok Kim, Jitae Kim, Sang Han Chung, Hyun-Seung Shin, Jung-Rok Lee, Euichul Hwang