Abstract: The present invention relates to an antigen-binding molecule comprising a heavy chain variable region comprising a heavy-chain complementarity-determining region 1 (HCDR1) comprising an amino acid sequence represented by Sequence No. 1, an HCDR2 comprising an amino acid sequence represented by Sequence No. 2, and an HCDR3 comprising an amino acid sequence represented by Sequence No. 3; a light-chain variable region comprising a light-chain complementarity-determining region 1 (LCDR1) comprising an amino acid sequence represented by Sequence No. 4, an LCDR2 comprising an amino acid sequence represented by Sequence No. 5, and an LCDR3 comprising an amino acid sequence represented by Sequence No. 6; wherein the antigen-binding molecule is a T cell receptor (TCR); and to a cell line expressing the same.

Abstract: Provided herein are formulations and drug product processes that can improve cell viability and minimize waste of the manufactured formulated cells for a drug product.

Abstract: This invention is directed to 3-(diheteroarylmethylene)-8-azabicyclo[3.2.1] octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo[3.2.1] octane derivatives useful as ?-opioid, ?-opioid, or ?-opioid and ?-opioid receptor receptor modulators. Depending on their agonist or antagonist effect, the compounds are useful analgesics, immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.

Abstract: This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.

Abstract: This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.

Abstract: The present invention provides compounds of the formula: wherein m is 0, 1 or 2; p is 0 or 1; Y is O, S, S(O) or S(O)2 and R1 to R7 are various substituents as selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function.

Abstract: This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.

Abstract: The present invention provides compounds of the formula: 1

Abstract: The present invention provides compounds of the formula: wherein m is 0, 1 or 2; p is 0 or 1; Y is O, S, S(O) or S(O)2 and R1 to R7 are various substituents as selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function.

Abstract: A globe valve with a strainer.The globe valve with a strainer comprising a valve body having a valve box, a strainer body, the valve box and the strainer body extending upwardly and downwardly respectively at an angle of about 45.degree. to the axis of the valve body, a valve seat hole positioned at the intersection of the axes of the valve body and the valve box, the surface of the vavle seat hole formed at an angle of about 90.degree. with the axis of the valve box, a hole positioned at the intersection of the axes of the valve body and the strainer body, the surface of the hole formed at an angle of about 90.degree. with the axis of the strainer body.

Abstract: A D.C. multi-phase brushless motor having M phase stator windings and an N pole rotor, with M and N being integers, a sensor for sensing rotor position and providing rotor position signals to a motor controller is disclosed. The sensor comprises a circular permanent magnet, mounted externally to a motor at one end of a rotor with the magnet having N poles, and M sets of paired Hall effect devices, mounted adjacent the magnet, wherein each of the M sets of paired Hall effect devices are mounted in adjustable relationship to the magnet with respect to radial and angular distance. The sensor is mounted within a housing mounted externally to an end of a motor adjacent the rotor end having the magnet mounted thereon with the M sets of paired Hall effect devices mounted within and upon the housing in adjustable relationship with the magnet.