Abstract: The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, a pharmaceutical use thereof, and a method for preparing the same. According to the present invention, the novel compounds, optical isomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; internal secretion; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, and chromosomal aberration.

Abstract: The present invention relates to a coating composition which is for a wiper blade and is for forming a coating layer for lowering the coefficient of friction of a wiper blade rubber base on glass, the coating composition including a lubricant additive and a solvent, wherein the lubricant additive is functionalized graphene capable of self-adhesion to the wiper blade rubber base.

Abstract: A cassette for ultra-thin glass includes a pair of plates spaced apart from and facing each other, and a plurality of supports mounted between the pair of plates and including a plurality of mounting grooves that support sides of sheets of ultra-thin glass. Each of the plurality of mounting grooves includes an inclined portion inclined toward a middle of each of the plurality of mounting grooves, and a straight portion extending from the inclined portion and having a constant width in an axial direction of the plurality of supports. A height of the straight portion in a radial direction of the plurality of supports is equal to or greater than a height of the inclined portion in the radial direction.

Abstract: The present invention relates to a novel compound having a selective HDAC6 inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof in preparation of a therapeutic medicament, a pharmaceutical composition containing the same, a therapeutic method using the composition, and a method for preparing the same, wherein the novel compound having the selective HDAC6 inhibitory activity is represented by chemical formula (I) below.

Abstract: Methods and apparatuses are provided for measuring a biometric signal by an electronic device. An object having an animation effect for inhalation and exhalation is displayed. The animation effect includes the object being expanded to guide the inhalation of a user and the object being contracted to guide exhalation of the user. A sensor unit obtains at least one biometric signal related to a heart rate of the user while the object is displayed. A motion of the electronic device is detected having a strength that is greater than or equal to a threshold strength. Based on the motion ceasing before exceeding a predetermined time, display of the object and obtaining of the at least one biometric signal is continued. Based on the motion lasting longer than or equal to the predetermined time, the obtaining of the at least one biometric signal and the displaying of the object is terminated.

Abstract: The present invention relates to 1,3,4-oxadiazole derivative compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a therapeutic method using the composition, and a method for preparing the same, and the 1,3,4-oxadiazole derivative compounds are represented by a following chemical formula (I).

Abstract: The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a medicinal use thereof, and a method for preparing the same. The novel compounds according to the present invention, stereoisomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; endocrinopathy; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, or chromosomal aberration.

Abstract: An electronic device for enhancing accuracy upon contactless body temperature measurement is provided. The electronic device includes an image sensor for obtaining an image of an object, a temperature sensor disposed at a position adjacent to the image sensor for measuring a temperature of the obtained object, and a controller for performing control to determine the temperature of the object using a focal length of a camera module including the image sensor corresponding to a time of obtaining the image of the object and a temperature output from the temperature sensor corresponding to the time of obtaining the image of the object.

Abstract: Methods and apparatuses are provided for measuring a biometric signal by an electronic device. An object having an animation effect for inhalation and exhalation is displayed. The animation effect includes the object being expanded to guide the inhalation of a user and the object being contracted to guide exhalation of the user. A sensor unit obtains at least one biometric signal related to a heart rate of the user while the object is displayed. A motion of the electronic device is detected having a strength that is greater than or equal to a threshold strength. Based on the motion ceasing before exceeding a predetermined time, display of the object and obtaining of the at least one biometric signal is continued. Based on the motion lasting longer than or equal to the predetermined time, the obtaining of the at least one biometric signal and the displaying of the object is terminated.

Abstract: Provided is a method of displaying location information of a bursa, which includes: obtaining shoulder ultrasound image data; detecting a fat layer located between a deltoid muscle and a tendon, based on information about an intensity of an echo signal contained in the shoulder ultrasound image data; detecting the bursa located between the fat layer and the tendon by using a location of the fat layer; and displaying the location information of the bursa on a shoulder ultrasound image generated based on the shoulder ultrasound image data.

Abstract: Methods and apparatuses are provided for measuring a vital signal. An application is executed to output vital information of a user wearing an electronic device. Instructions are output that guide inhalation and exhalation of the user based on the executed application. At least one vital signal for the user is obtained while outputting the instructions. Vital information corresponding to the obtained at least one vital signal is output.

Abstract: The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, a pharmaceutical use thereof, and a method for preparing the same. According to the present invention, the novel compounds, optical isomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; internal secretion; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, and chromosomal aberration.

Abstract: The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) in-hibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds.

Abstract: A microbubble used as a contrast agent for ultrasound imaging burst due to high intensity of ultrasound, and the burst microbubble effectively acts as a contrast agent for photoacoustic imaging. Based on this point, a new apparatus and method for combined photoacoustic and ultrasound diagnosis are provided.

Abstract: Methods and apparatuses are provided for measuring a vital signal. An application is executed to output vital information of a user wearing an electronic device. Instructions are output that guide inhalation and exhalation of the user based on the executed application. At least one vital signal for the user is obtained while outputting the instructions. Vital information corresponding to the obtained at least one vital signal is output.

Abstract: The present disclosure relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds.

Abstract: Provided is a method of marking a diffusion boundary of medicine, the method performed by an ultrasound apparatus and including operations of obtaining first B mode image data and first Doppler data about a target object to which the medicine is injected; detecting a first area of the target object from which the first Doppler data is obtained; determining a first diffusion boundary of the medicine, based on the first area; and marking the first diffusion boundary of the medicine on a B mode image that is generated by using the first B mode image data.

Abstract: A method of managing a plurality of applications executed on an electronic device is provided. The method includes, based on a first external input regarding at least one application from among the plurality of applications, updating mode of the at least one application from a non-work mode to a work mode, based on the first external input, updating mode of another application other than the at least one application from a work mode to a non-work mode, and displaying a work time regarding the at least one application that is determined based on at least one of information indicating a time point at which the first external input is obtained and information indicating a time point at which the mode of the at least one application is updated from the non-work mode to the work mode.

Abstract: An electronic device for enhancing accuracy of a contactless body temperature measurement is provided. The electronic device includes a camera module for determining whether an image of an object is in focus, a temperature sensor for measuring a temperature of the object, and a processor for determining, as a temperature of the object, a temperature output from the temperature sensor corresponding to a focus matching time as a result of determining whether the image of the object is in focus.

Abstract: Provided is a photoacoustic probe. The photoacoustic probe is configured to control light emitted from an optical unit by using a shutter that is switched between a state in which the shutter is opened to allow light to pass therethrough and a state in which the shutter blocks the light according to whether an inspection starts.