Abstract: The current disclosure is centered on the hypothesis that a better understanding of the neuroendocrine transdifferentiation (NEtD) process will provide therapeutic targets for inhibiting this transition and thus improving standard of care therapies. Accordingly, the current disclosure provides for a method for treating cancer in a subject, the method comprising administering an inhibitor of a gene, wherein the gene comprises one or more of tenascin C (TNC), advillin (AVIL), S100A7, PPARG, LOX lysyl oxidase, KLF5, APOBEC2, FOSL1, FOXM1, hedgehog, RELA, p65, IKK complex, JAK, STAT, TFAP4, geminin, OCA-1, OCA-2, Nf-kB, Nf-kB family and associated regulators, angiogenesis regulators such as BMX kinase, TEK kinase, periostin (POSTN), and VEGF family, stress genes, such as the JUN/FOS family, a gene from the S100 family, and cell state regulators such as ASCL1, POU2F3, NEUROD1, ASCL2, and YAP1.

Abstract: An integrated power conversion apparatus for an electric vehicle according to the present disclosure includes a first H-bridge converter with one side connected to a high voltage battery; a three-winding transformer in which a primary winding is connected to the other side of the first H-bridge converter; a second H-bridge converter with one side which is connected to a secondary winding of the three-winding transformer; an AC-DC converter in which one side is connected to the other side of the second H-bridge converter and the other side is selectively connected to a motor or a power system; and a low voltage stage converter in which one side is selectively connected to a tertiary winding of the three-winding transformer through a selective switch and the other side is connected to a low voltage battery.

Abstract: Proposed is a charger control device, to which a circulating current reduction control technique is applied, for a parallel CLLC converter module for an electric vehicle charger. The charger control device according to an exemplary embodiment includes a first PI controller receiving an input related to a voltage, a second PI controller receiving an input related to a current, a first operator calculating a result value of the first PI controller and a result value of the second PI controller, a PSM controller outputting a switch operation signal according to a PSM control based on the result value of the first operator, and a PFM controller outputting a switch operation signal according to a PFM control based on the result value of the first operator.

Abstract: Examples of an automated micropropagation system for plant tissue culture is provided. The system comprises a culture vessel that comprises a number of detachable culture items that are designed with a plurality of culture cells sized to accept a single plantlet. Such culture vessel is fed into the system to an automated gripper and cutter assembly that is configured to grip the plantlets, cut them and transfer them into a new culture vessel.

Abstract: An integrated power conversion apparatus for an electric vehicle according to the present disclosure includes a first H-bridge converter with one side connected to a high voltage battery; a three-winding transformer in which a primary winding is connected to the other side of the first H-bridge converter; a second H-bridge converter with one side which is connected to a secondary winding of the three-winding transformer; an AC-DC converter in which one side is connected to the other side of the second H-bridge converter and the other side is selectively connected to a motor or a power system; and a low voltage stage converter in which one side is selectively connected to a tertiary winding of the three-winding transformer through a selective switch and the other side is connected to a low voltage battery.

Abstract: A method, system, and computer program product are disclosed for implementing enhanced expertise and evidence based decision making in knowledge-based applications. Expertise and evidence based decision making operations include differentiating between an average user and an expert user, and using real time feedback from expert users to update and embed expert knowledge into a predefined baseline command sequence model for a given task or problem.

Abstract: Springs can provide energy return and have a conductivity that changes in relation to an amount of strain or deformation of the spring. An upper-extremity prosthetic device includes a first coil spring coupled to a first member and a first cantilever spring extending from the first member to a surface adapted to engage with an object. The first coil spring is arranged to absorb energy and to provide energy return in response to movement of the first member. The first coil spring includes a first conductive surface and a second conductive surface separate from the first conductive surface by non-conductive surfaces. The first cantilever spring includes a conductive trace with a plurality of conductive segments arranged on the conductive trace.

Abstract: The present disclosure relates to electronic devices and methods of manufacturing electronic devices. A method of manufacturing a dissolvable electronic device includes forming a dissolvable sheet; applying a self-sintering agent to the dissolvable sheet to form a substrate; and depositing electrically conductive ink onto the substrate in a trace. A method of manufacturing a meltable electronic device includes mixing a conductive material with a melted wax to form a conductive wax mixture in liquid form; molding the conductive wax mixture; and solidifying the conductive wax mixture to obtain the meltable electronic device. A method of manufacturing an edible electronic device includes cutting a layer of conductive material to form a pattern that defines a circuit; applying the layer of conductive material to an edible medium, wherein the edible medium is in liquid or semi-solid form; and solidifying the edible medium to obtain the edible electronic device.

Abstract: Disclosed is a method of cooperatively controlling power based on power sensitivity that is executed by at least one processor including obtaining a first power sensitivity parameter based on a power generation change amount of a distribution grid to a magnitude change amount of an arbitrary load, receiving a feasible operation region (FOR) of the distribution grid from a distribution grid operator corresponding to the distribution grid including a plurality of generators, determining final reference power of the distribution grid based on the first power sensitivity parameter and the FOR, and transmitting the final reference power to the distribution grid operator.

Abstract: According to the integrated power conversion apparatus and method according to the exemplary embodiment of the present disclosure, the on-board battery charger (OBC), the lower voltage battery charger (LDC), and the traction converter (TC) are integrated to convert the power so that all the functions which need to be performed by the power conversion system of the related art can be performed. Further, the number of switches is reduced to increase a power density and not only the number of switches, but also the number of controllers is reduced to improve feasibility.

Abstract: A method for manufacturing a high-strength steel bar can include the steps of: reheating a steel slab at a temperature ranging from 1000° C. to 1100° C., the steel slab including a certain amount of carbon (C), silicon (Si), manganese (Mn), phosphorus (P), sulfur (S), chromium (Cr), copper (Cu), nickel (Ni), molybdenum (Mo), aluminum (Al), vanadium (V), nitrogen (N), antimony (Sb), tin (Sn), and iron (Fe) and other inevitable impurities, The method can further include finish hot-rolling the reheated steel slab at a temperature of 850° C. to 1000° C., and cooling the hot-rolled steel to a martensite transformation start temperature (Ms (° C.)) through a tempcore process.

Abstract: Examples of a device for guiding and detecting a motion of a target joints and a motion assistance system such motion guiding devices are described. The motion guiding and detecting device comprises a motion generator and a motion transfer and target interfacing unit to transfer the motion generated by the motion generator to the target joint. The system further includes a motion detection and feedback unit that interfaces with the target, and a controller that interfaces with both the feedback unit and the motion generator to control and coordinate the motion of the motion generator and the target joint.

Abstract: Examples of a motion guiding device of a target joint of a target body are disclosed. The device allows three degree-of-freedom (DOF) motion about a remote center of rotation that is approximately aligned to a center of rotation of the target joint. The device comprises a base adjustably connected to the target body and three rotary joints interconnected with a network of linkages. One end of the network of linkages is connected to the base and the opposite end to an effector plate. At least one of the three rotary joints is not aligned with an axes of motion of the target joint and any of these rotary joints may be positioned under angle with respect to the others. Each of the rotary joints provides one DOF of rotary motion about the respective axes and each axis of the three rotary joints intersect at the remote center of rotation. The geometry of the network of linkages is adjustable to adjust a position of the remote center of rotation in three dimensions.

Abstract: According to the integrated power conversion apparatus and method according to the exemplary embodiment of the present disclosure, the on-board battery charger (OBC), the lower voltage battery charger (LDC), and the traction converter (TC) are integrated to convert the power so that all the functions which need to be performed by the power conversion system of the related art can be performed. Further, the number of switches is reduced to increase a power density and not only the number of switches, but also the number of controllers is reduced to improve feasibility.

Abstract: A method for manufacturing a high-strength steel bar can include the steps of: reheating a steel slab at a temperature ranging from 1000° C. to 1100° C., the steel slab including a certain amount of carbon (C), silicon (Si), manganese (Mn), phosphorus (P), sulfur (S), chromium (Cr), copper (Cu), nickel (Ni), molybdenum (Mo), aluminum (Al), vanadium (V), nitrogen (N), antimony (Sb), tin (Sn), and iron (Fe) and other inevitable impurities, The method can further include finish hot-rolling the reheated steel slab at a temperature of 850° C. to 1000° C., and cooling the hot-rolled steel to a martensite transformation start temperature (Ms (° C.)) through a tempcore process.

Abstract: The current disclosure provides for methods of identifying and treating small cell neuroendocrine (SCN) tumors and small-round-blue cell tumor (SRBCT). Aspects of the disclosure relate to a method comprising measuring the level of expression of one or more biomarkers from Tables 1-3 in a biological sample from a cancer patient. Further aspects relate to a method for treating small cell neuroendocrine (SCN) cancer or small-round-blue cell tumor (SRBCT) in a patient comprising administering a cancer treatment to the patient, wherein the cancer treatment is a treatment selected from Table 4A, 4B, or combinations of treatments from Table 4A and/or 4B.

Abstract: The present disclosure provides substantially magnetometer-free systems and methods for motion capture of a subject including 3-D localization and posture tracking by fusing inertial sensors with a localization system and a biomechanical model of the subject. Using the novel Kalman filter based fusion techniques disclosed herein, the localization data aided with the biomechanical model can eliminate the drift in inertial yaw angle estimation.

Abstract: Examples of an automated micropropagation system for plant tissue culture is provided. The system comprises a culture vessel that comprises a number of detachable culture items that are designed with a plurality of culture cells sized to accept a single plantlet. Such culture vessel is fed into the system to an automated gripper and cutter assembly that is configured to grip the plantlets, cut them and transfer them into a new culture vessel.

Abstract: A data processing system includes a processor operable to execute a program partitioned into a number of discrete instructions, the processor having multiple processing elements each capable of executing more than one instruction per cycle, and an interface configured to read a first program and, on detecting a branch operation by that program creating m number of branches each having a different sequence of instructions, combine an instruction from one of the branches with an instruction from at least one other branch so as to cause a processing element to execute the combined instructions during a single cycle.

Abstract: A wireless charging system comprises at least one wireless power transmitter at a fixed location, at least two wireless communication beacons in proximity and at known locations relative to the wireless power transmitter, and a portable electronic device in proximity to the wireless power transmitter. The portable electronic device comprises a wireless power receiver connected to charge a battery through a tunable power electronic circuit, a wireless communication receiver, a 3-axis accelerometer, a 3-axis magnetometer, a 3-axis gyroscope, and a controller configured to determine the position and orientation of the wireless power receiver with respect to the wireless power transmitter and tune the tunable power electronic circuit based on the determined orientation.