Abstract: In an embodiment, a microfluidic chip includes a capillary is disposed between upper and lower substrates, where the capillary includes a porous monolithic structure disposed within the capillary, and a clamp structure is defined within the channel and engages with the capillary. The clamp structure comprises a thermoplastic material that, when heated to a selected temperature, deforms around the capillary to secure the capillary in alignment with the channel. In another embodiment, a microfluidic chip includes a porous monolithic brick disposed between first and second substrates, where each of the first and second substrates includes a channel extending through the substrate to the brick structure to provide a fluid flow path through the each of the first substrate, the second substrate and the brick structure.

Abstract: A first inlet flow can be directed along an axial direction in a hydrocyclonic flow cell. The first inlet flow can include first constituent molecules. At a same time, one or more second inlet flows can be directed along a circumferential direction of the hydrocyclonic flow cell. Each second inlet flow can include a buffer solution. The first inlet flow can be subjected to flow focusing by a surrounding primary vortex formed by the one or more second inlet flows, so as to generate a flow comprising a plurality of nanoparticles at an outlet of the hydrocyclonic flow cell. Each nanoparticle can be formed by a respective plurality of the first constituent molecules.

Abstract: In an embodiment, a microfluidic chip includes a capillary is disposed between upper and lower substrates, where the capillary includes a porous monolithic structure disposed within the capillary, and a clamp structure is defined within the channel and engages with the capillary. The clamp structure comprises a thermoplastic material that, when heated to a selected temperature, deforms around the capillary to secure the capillary in alignment with the channel. In another embodiment, a microfluidic chip includes a porous monolithic brick disposed between first and second substrates, where each of the first and second substrates includes a channel extending through the substrate to the brick structure to provide a fluid flow path through the each of the first substrate, the second substrate and the brick structure.