Abstract: Disclosed is a multi-band multiplexing intra-cavity gas sensing system and method. The system consists of a laser resonant cavity subsystem, a gas sensing subsystem and a detection-demodulation subsystem. The laser resonant cavity subsystem consists of the first beam splitter, two ways of gain paths composed of a pump light source, a wavelength division multiplexer, a rare earth doped fiber, an optical isolator and a tunable optical attenuator, a beam combiner and an F-P tunable optical filter. The gas sensing subsystem consists of a gas cell and an optical reflective mirror. The detection-demodulation subsystem consists of an optical coupler, the second beam splitter, two optical detectors, a data acquisition module and a computer. In this invention, different rare-earth doped fibers are multiplexing into one system, in order to cover more maser bands of different rare earth, which greatly expands the scanning range of wavelength, and is capable of detecting various gases simultaneously.