Abstract: The present disclosure relates to a method for producing an inner ear organoid with improved differentiation efficiency of hair cells. The inventors of the present disclosure have confirmed that when retinoic acid is treated at the stage of formation of the lamina propria during the production of an inner ear organoid, the differentiation potential of hair cells is excellent. Therefore, it is expected that the inner ear organoid produced according to the production method of the present disclosure can be advantageously utilized in hearing loss disease modeling, drug screening and regenerative medicine.

Abstract: A secondary battery which can improve safety is provided. The secondary battery includes an electrode assembly, a can accommodating the electrode assembly and a cap assembly coupled to a top portion of the can, wherein the cap assembly comprises a cap-up, a safety vent installed under the cap-up, a cap-down installed under the safety vent, an insulator interposed between the safety vent and the cap-down, and a sub-plate positioned on a bottom surface of the cap-down, and an insulation layer is formed on a top surface of the cap-down.

Abstract: A secondary battery which can improve safety is provided. The secondary battery includes an electrode assembly, a can accommodating the electrode assembly and a cap assembly coupled to a top portion of the can, wherein the cap assembly comprises a cap-up, a safety vent installed under the cap-up, a cap-down installed under the safety vent, an insulator interposed between the safety vent and the cap-down, and a sub-plate positioned on a bottom surface of the cap-down, and an insulation layer is formed on a top surface of the cap-down.