Abstract: The present invention relates to an antigen-binding molecule comprising a heavy chain variable region comprising a heavy-chain complementarity-determining region 1 (HCDR1) comprising an amino acid sequence represented by Sequence No. 1, an HCDR2 comprising an amino acid sequence represented by Sequence No. 2, and an HCDR3 comprising an amino acid sequence represented by Sequence No. 3; a light-chain variable region comprising a light-chain complementarity-determining region 1 (LCDR1) comprising an amino acid sequence represented by Sequence No. 4, an LCDR2 comprising an amino acid sequence represented by Sequence No. 5, and an LCDR3 comprising an amino acid sequence represented by Sequence No. 6; wherein the antigen-binding molecule is a T cell receptor (TCR); and to a cell line expressing the same.

Abstract: A fuel cell power plant (9) includes a stack (10) of fuel cells, each including anodes (11), cathodes (12), coolant channels (13) and either (a) a coolant accumulator (60) and a pump (61) or (b) a condenser and cooler fan. During shutdown, electricity generated in the fuel cell in response to boil-off hydrogen gas (18) powers a controller (20), an air pump (52), which may increase air utilization to prevent cell voltages over 0.85 during shutdown, and either (a) the coolant pump or (b) the cooler fan. Operation of the fuel cell keeps it warm; circulating the warm coolant prevents freezing of the coolant and plumbing. The effluent of the cathodes and/or anodes is provided to a catalytic burner (48) to consume all hydrogen before exhaust to ambient. An HVAC in a compartment of a vehicle may operate using electricity from the fuel cell during boil-off.

Abstract: A fuel cell power plant (10) includes a fuel cell (12) having a membrane electrode assembly (MEA) (16), disposed between an anode support plate (14) and a cathode support plate (18), the anode and/or cathode support plates include a hydrophilic substrate layer (80, 82) having a predetermined pore size. The pressure of the reactant gas streams (22, 24) is greater than the pressure of the coolant stream (26), such that a greater percentage of the pores within the hydrophilic substrate layer contain reactant gas rather than water. Any water that forms on the cathode side of the MEA will migrate through the cathode support plate and away from the MEA. Controlling the pressure also ensures that the coolant water will continually migrate from the coolant stream toward the anode side of the MEA, thereby preventing the membrane from becoming dry. Proper pore size and a pressure differential between coolant and reactants improves the electrical efficiency of the fuel cell.

Abstract: A fuel cell power plant (9) includes a stack (10) of fuel cells, each including anode (11), cathodes (12), coolant channels (13) and either (a) a coolant accumulator (60) and pump (61) or (b) a condenser and cooler fan. During shutdown, electricity generated in the fuel cell in response to boil-off hydrogen gas (18) powers a controller (20), an air pump (52), which may increase air utilization to prevent cell voltages over 0.85V during shutdown, and either (a) the coolant pump or (b) the cooler fan. Operation of the fuel cell keeps it warm; circulating the warm coolant prevents freezing of coolant and plumbing. The effluent of the cathodes and/or anodes is provided to a catalytic burner (48) to consume all hydrogen before exhaust to ambient. An HVAC in a compartment of a vehicle may operate using electricity from the fuel cell during boil-off.

Abstract: A fuel cell power plant includes a fuel cell having a membrane electrode assembly (MEA), disposed between an anode support plate and a cathode support plate, the anode and/or cathode support plates include a hydrophilic substrate layer having a predetermined pore size. The pressure of the reactant gas streams is greater than the pressure of the coolant stream, such that a greater percentage of the pores within the hydrophilic substrate layer contain reactant gas rather than water. Any water that forms on the cathode side of the MEA will migrate through the cathode support plate and away from the MEA. Controlling the pressure also ensures that the coolant water will continually migrate from the coolant stream toward the anode side of the MEA, thereby preventing the membrane from becoming dry. Proper pore size and a pressure differential between coolant and reactants improves the electrical efficiency of the fuel cell.

Abstract: A fuel cell includes a membrane electrode assembly (46) having a first reactant flow field (80) secured adjacent a first or second surface (48, 50) of the assembly (46) for directing flow of a first reactant adjacent the first or second surface of the assembly (46). The first reactant flow field (80) defines a plurality of two-pass circuits (82, 84, 86, 88), and each two-pass circuit (82) is in fluid communication with both a first reactant inlet (90) for directing the first reactant into the fuel cell (12), and with a first reactant outlet (92) for directing the first reactant out of the fuel cell (12). The plurality of two-pass circuits (82) facilitate water movement (112) toward the reactant inlet (90) to aid in passive maintenance of fuel cell (12) water balance.

Abstract: A plurality of fuel cell stacks (8, 8a, 9, 9a) have their cathode ends (11, 12) contiguous with either a common current collector (15a–15d) or respective current collectors (15a, 15b) which may be separated by electrical isolation (27a, 27b). The cathode-to-cathode relationship protects the cathode of each of the stacks from cold ambient environments, thereby permitting improved cold starts and mitigation of performance loss as a result of cold starts as well as freeze/thaw cycles. Heaters (30, 30a–30d) may be provided in current collectors, or in or between electrical isolation. Four stacks may share one current collector, or each may have its own current collector.

Abstract: Each cell of a fuel cell stack is provided, between the anode 37 and cathodes 38, with either (a) a permanent shunt (20) which may be a discrete resistor (42-44), a diode (95), a strip of compliant carbon cloth (65), or a small amount of conductive carbon black (22) in the ionomer polymer mixture of which the proton exchange membrane (39) is formed, or (b) a removeable shunt such as a conductor (69) which may be rotated into and out of contact with the fuel cell anodes and cathodes, or a conductor (85) which may be urged into contact by means of a shape memory alloy actuator spring (90, 91), which may be heated.

Abstract: The fuel cells (16, 18) adjacent or near the end plate (15) of a fuel cell stack (14) are warmed either by (a) a heater wire (48, 50) within the fuel cell (16) adjacent to the end plate, (b) heater wires (53) disposed in a heater element (52) located between the end plate and the fuel cell closest to the end plate (15), (c) one or more heaters (56) are disposed in holes (55) within the end plate (15), (d) a catalytic heater (61) disposed on the inner surface of the end plate, or (e) catalytic burner (78, 100) disposed adjacent a current collector (70) between an end cell (16) and insulation (81) on an end plate (82). The fuel cells (16, 18) may be heated before or during startup at sub-freezing temperatures to prevent loss of fuel cell performance.

Abstract: The fuel cells (16, 18) adjacent or near the end plate (15) of a fuel cell stack (14) are warmed either by (a) a heater wire (48) within the fuel cell (16) adjacent to the end plate, (b) heater wires (53) are disposed in a heater element (52) located between the end plate and the fuel cell closest to the end plate (15), (c) one or more heaters (56) are disposed in holes (55) within the end plate (15), (d) electric heating elements (59) on a surface of the end plate (15), or (e) a catalytic heater (61) disposed on the surface of the end plate. The fuel cells (16, 18) may be heated before or during operation at sub-freezing temperatures to prevent loss of fuel cell performance, or may be heated after operation at sub-freezing temperatures to restore fuel cell performance.

Abstract: A proton exchange membrane (PEM) fuel cell includes fuel and oxidant flow field plates (26, 40) having fuel and oxidant channels (27, 28; 41, 44), and water channels, the ends (29, 48) of which that are adjacent to the corresponding reactant gas inlet manifold (34, 42) are dead ended, the other ends (31, 50) draining excess water into the corresponding reactant gas exhaust manifold (36, 45). Flow restrictors (39, 47) maintain reactant gas pressure above exit manifold pressure, and may comprise interdigitated channels (65, 66; 76, 78). Solid reactant gas flow field plates have small holes (85, 88) between reactant gas channels (27, 28; 41) and water drain channels (29, 30; 49, 50). In one embodiment, the fuel cells of a stack may be separated by either coolant plates (51) or solid plates (55) or both.

Abstract: A fuel cell power plant includes a fuel cell having a membrane electrode assembly (MEA), which is disposed between anode and cathode support plates. Porous water transport plates or the support plates have interdigitated flow channels for the reactant gas streams to pass through and conventional flow channels for coolant streams to pass through. The pressure of the reactant gas streams is greater than the coolant stream which, within the porous water transport plates allows the coolant water to saturate the water transport plates thereby forcing the reactant gases into the anode and cathode support plates. This, in turn, increases the mass transfer of such gases into the support plates, thereby increasing the electrical performance of the fuel cell. Current densities of about 1.6 amps per square centimeter are achieved with air stochiometries of not over 2.50.

Abstract: A fuel cell power plant includes a fuel cell having a membrane electrode assembly (MEA), disposed between an anode support plate and a cathode support plate, the anode and/or cathode support plates include a hydrophilic substrate layer having a predetermined pore size. The pressure of the reactant gas streams is greater than the pressure of the coolant stream, such that a greater percentage of the pores within the hydrophilic substrate layer contain reactant gas rather than water. Any water that forms on the cathode side of the MEA will migrate through the cathode support plate and away from the MEA. Controlling the pressure also ensures that the coolant water will continually migrate from the coolant stream toward the anode side of the MEA, thereby preventing the membrane from becoming dry. Proper pore size and a pressure differential between coolant and reactants improves the electrical efficiency of the fuel cell.

Abstract: Each cell of a fuel cell stack is provided, between the anode 37 and cathodes 38, with either (a) a permanent shunt (20) which may be a discrete resistor (42-44), a diode (95), a strip of compliant carbon cloth (65), or a small amount of conductive carbon black (22) in the ionomer polymer mixture of which the proton exchange membrane (39) is formed, or (b) a removeable shunt such as a conductor (69) which may be rotated into and out of contact with the fuel cell anodes and cathodes, or a conductor (85) which may be urged into contact by means of a shape memory alloy actuator spring (90, 91), which may be heated.

Abstract: The invention is a bi-zone water transport plate for a fuel cell wherein the plate includes a water permeability zone and a bubble barrier zone. The bubble barrier zone extends between all reactive perimeters of the plate, has a pore size of less than 20 microns, and has a thickness of less than 25 percent of a shortest distance between opposed contact surfaces of the plate. The water permeability zone has a pore size of at least 100 percent greater than the pore size of the bubble barrier zone, and has a thickness of greater than 75 percent of the shortest distance between the opposed contact surfaces of the plate. By having a separate bubble barrier zone, the plate affords enhanced water permeability while the bubble barrier maintains a gas seal.

Abstract: A proton exchange membrane (PEM) fuel cell includes fuel and oxidant flow field plates (26, 40) having fuel and oxidant channels (27, 28; 41, 44), and water channels, the ends (29, 48) of which that are adjacent to the corresponding reactant gas inlet manifold (34, 42) are dead ended, the other ends (31, 50) draining excess water into the corresponding reactant gas exhaust manifold (36, 45). Flow restrictors (39, 47) maintain reactant gas pressure above exit manifold pressure, and may comprise interdigitated channels (65, 66; 76, 78). Solid reactant gas flow field plates have small holes (85, 88) between reactant gas channels (27, 28; 41) and water drain channels (29, 30; 49, 50). In one embodiment, the fuel cells of a stack may be separated by either coolant plates (51) or solid plates (55) or both.

Abstract: A fuel cell having a polymer electrolyte membrane (16) between anode (14) and cathode (18) reactant flow fields includes a variable blower (32), the power control signal (61) of which is provided by a controller (75) in response to a current signal (63) indicative of the current of the load (71) sensed by a current detector (68). The controller responds to a schedule of blower power as a function of load current density to provide a stochiometry, S, which is fixed at a stochiometry of A, plus or minus a range of stochiometries, D, below a certain current density, C, and varies with higher current densities as: S=[A+B(i−C)]±D, where B is he slope of stochiometry as a function of current density, and i is the actual current density.

Abstract: The invention is a bi-zone water transport plate for a fuel cell wherein the plate includes a water permeability zone and a bubble barrier zone. The bubble barrier zone extends between all reactive perimeters of the plate, has a pore size of less than 20 microns, and has a thickness of less than 25 percent of a shortest distance between opposed contact surfaces of the plate. The water permeability zone has a pore size of at least 100 percent greater than the pore size of the bubble barrier zone, and has a thickness of greater than 75 percent of the shortest distance between the opposed contact surfaces of the plate. By having a separate bubble barrier zone, the plate affords enhanced water permeability while the bubble barrier maintains a gas seal.

Abstract: Fuel Cell Having a Hydrophilic Substrate Layer A fuel cell power plant includes a fuel cell having a membrane electrode assembly (MEA), disposed between an anode support plate and a cathode support plate, the anode and/or cathode support plates include a hydrophilic substrate layer having a predetermined pore size. The pressure of the reactant gas streams is greater than the pressure of the coolant stream, such that a greater percentage of the pores within the hydrophilic substrate layer contain reactant gas rather than water. Any water that forms on the cathode side of the MEA will migrate through the cathode support plate and away from the MEA. Controlling the pressure also ensures that the coolant water will continually migrate from the coolant stream toward the anode side of the MEA, thereby preventing the membrane from becoming dry. Proper pore size and a pressure differential between coolant and reactants improves the electrical efficiency of the fuel cell.

Abstract: PEM fuel cell performance losses caused by phenomena occurring during normal cell operation are recovered by periodically reducing the cathode potential to about 0.6 volts or less, and preferably to 0.1 volt or less. Once the cathode potential is reduced to the desired low level, it is maintained at or below that level for a period of time. The lower the potential to which the cathode is brought, the more quickly regeneration will occur. After regeneration, the cell, when returned to normal operation, will operate at a higher performance level.