Patents by Inventor Junhai Yang

Junhai Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10996227
    Abstract: Pre-coated analysis substrates, and methods of making the substrates and using them to analyze animal tissue, are described. The pre-coated analysis substrates can be made by forming a matrix surface on an analysis substrate; adding a protease to the matrix surface to form a pre-coated analysis substrate; and placing an animal tissue specimen on the matrix surface. The animal tissue can then be analyzed by allowing the protease to partially digest the animal tissue specimen; and analyzing the partially digested animal tissue specimen by mass spectrometry.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: May 4, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Richard Caprioli, Junhai Yang, Jeremy L. Norris, Faizan Zubair, Paul Edward Laibinis
  • Publication number: 20170067906
    Abstract: Pre-coated analysis substrates, and methods of making the substrates and using them to analyze animal tissue, are described. The pre-coated analysis substrates can be made by forming a matrix surface on an analysis substrate; adding a protease to the matrix surface to form a pre-coated analysis substrate; and placing an animal tissue specimen on the matrix surface. The animal tissue can then be analyzed by allowing the protease to partially digest the animal tissue specimen; and analyzing the partially digested animal tissue specimen by mass spectrometry.
    Type: Application
    Filed: June 9, 2016
    Publication date: March 9, 2017
    Inventors: Richard Caprioli, Junhai Yang, Jeremy L. Norris, Faizan Zubair, Paul Edward Laibinis
  • Publication number: 20120021189
    Abstract: Sample preparation can be a tedious and time consuming task. For example, MALDI imaging of tissue samples can require the tedious process of hand or robotically spotting solutions containing chemical species referred to as “matrix” onto a tissue sample prior its mass spectral analysis. Provided is a process for preparing a sample comprising immersing a solid support that has a surface comprising a first part that is more hydrophilic than a second part into a target compound solution, wherein the target compound is deposited primarily onto the more hydrophilic part; and/or applying and evaporating the target compound solution onto the substrate to produce the pre-coated substrate. A tissue or other sample may then be placed on the substrate for analysis.
    Type: Application
    Filed: May 20, 2011
    Publication date: January 26, 2012
    Applicant: Vanderbilt University
    Inventors: Paul E. Laibinis, Richard Caprioli, Zhou Xu, Junhai Yang
  • Publication number: 20080113875
    Abstract: The present invention provides methods for obtaining information of a plurality of target molecules by matrix free LDI MS. Mass tagged complexes for detection of target molecules comprise a target molecule binding domain, and a mass tag separated by a cleavable linker. Methods of the invention may be used for example to analyze the distribution of a multiple target molecules in a complex sample, such as a tissue section.
    Type: Application
    Filed: September 7, 2007
    Publication date: May 15, 2008
    Inventors: Pierre Chaurand, Jeremy L. Norris, Ned A. Porter, Junhai Yang, Richard M. Caprioli