Patents by Inventor Junhua Liu

Junhua Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12378204
    Abstract: Certain triazole compounds have good LPAR1 antagonistic activity and selectivity, low toxicity, and good metabolic stability, and can be used for preventing or treating the LPAR1-related disease or disorder. The IC50 value of some triazole compounds can be below 300 nM, even 50 nM. The range of CC50 of the triazole compounds can be greater than 200 ?M. They also show good metabolic stability in human, fancy rats, and house mice.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: August 5, 2025
    Assignee: WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD.
    Inventors: Jun Lou, Yongkai Chen, Wei Peng, Yihan Zhang, Xiaodan Guo, Li Liu, Junhua Liu, Lina Qian, Chaodong Wang
  • Patent number: 12377083
    Abstract: Certain compounds are lysophosphatidic acid receptor antagonists have high LPAR1 antagonist activity and selectivity, low toxicity, good metabolic stability, promising pharmaceutical development prospects, and may be used for preventing or treating LPAR1-related diseases or illnesses. The IC50 values of some of the compounds may be as low as 300 nM or below, even 50 nM or below. In addition, CC50 value range of the compounds may be as high as 200 ?M or above. Furthermore, the compounds have good metabolic stability in humans, mice and rats.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: August 5, 2025
    Assignee: WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD.
    Inventors: Jun Lou, Yongkai Chen, Wei Peng, Yihan Zhang, Xiaodan Guo, Li Liu, Junhua Liu, Lina Qian, Chaodong Wang
  • Publication number: 20250112300
    Abstract: A battery, comprising a battery can housing including a main portion and a ledge that extends from a sidewall of the main portion at a transverse angle to the sidewall, an electrode stack housed within the main portion, and an electrical contact electrically coupled to the electrode stack. A portion of the electrical contact extends from the ledge at the transverse angle to the sidewall.
    Type: Application
    Filed: September 28, 2023
    Publication date: April 3, 2025
    Applicant: Apple Inc.
    Inventors: Depeng Wang, Angus S. Smith, Hirotsugu Oba, Junhua Liu
  • Publication number: 20250112340
    Abstract: A battery, comprising a battery can housing defining an opening, an electrode stack housed within the battery can housing, an internal electrode tab disposed within the interior volume. The internal electrode tab includes a conductive layer and an insulated lamination layer on the conductive layer, the conductive layer is electrically coupled to the electrode stack, and the insulated lamination layer is positioned between the conductive layer and the enclosure. An external electrode tab is electrically coupled to the conductive layer and positioned within the opening.
    Type: Application
    Filed: October 2, 2023
    Publication date: April 3, 2025
    Applicant: Apple Inc.
    Inventors: Depeng Wang, Angus S. Smith, Hirotsugu Oba, Junhua Liu
  • Patent number: 12244032
    Abstract: Battery systems according to embodiments of the present technology may include a battery including a first electrode terminal and a second electrode terminal accessible along a first surface of the battery. The battery may define a recessed portion of the battery along the first surface of the battery between the first electrode terminal and the second electrode terminal. The battery systems may include a module electrically coupled with the battery. The module may include a circuit board. The module may include a first conductive tab extending from a second surface of the circuit board opposite the first surface of the circuit board. The first conductive tab may be electrically coupling the module with the first electrode terminal. The module may include a second conductive tab extending from the second surface of the circuit board. The second conductive tab may be electrically coupling the module with the second electrode terminal.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: March 4, 2025
    Assignee: Apple Inc.
    Inventors: Hirotsugu Oba, Brian K. Shiu, Michael P. Zhang, Xiao Liu, Christopher R. Pasma, Steven M. Labovitz, Katharine R. Chemelewski, Erik D. Gillow, Joshua Walter, Junhua Liu, Michael H. Tsai, Stephan P. Abdo
  • Publication number: 20250033286
    Abstract: The disclosure provides an object shoveling mechanism, a 3D printer and a 3D printing method, and relates to the technical field of printing. The object shoveling mechanism is applied to the 3D printer. The 3D printer includes a forming platform, provided with a forming surface.
    Type: Application
    Filed: November 15, 2022
    Publication date: January 30, 2025
    Inventors: Junhua LIU, Jiajing ZHOU, Qingshan LIU, Shutian SU, Bingliang HUANG, Kaiwu LI
  • Publication number: 20240395242
    Abstract: Provided in the present application are a speech recognition method, apparatus and device, and a storage medium. The method comprises: acquiring a speech feature of target mixed speech and a speaker feature of a specified speaker; taking the direction of tending to a target speech feature as an extraction direction, and according to the speech feature of the target mixed speech and a speaker feature of a target speaker, extracting a speech feature of the target speaker from the speech feature of the target mixed speech, so as to obtain an extracted speech feature of the target speaker and acquiring a speech recognition result of the specified speaker according to an extracted speech feature of the specified speaker.
    Type: Application
    Filed: November 10, 2021
    Publication date: November 28, 2024
    Applicants: UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA, IFLYTEK CO., LTD.
    Inventors: Xin Fang, Junhua Liu
  • Publication number: 20240227610
    Abstract: A method of over-heating protection for a charging apparatus, includes: measuring a charging parameter of the charging apparatus during a charging process, where the charging parameter includes a temperature and a time corresponding to the temperature; estimating a temperature change trend of the charging apparatus based on the charging parameter; and when determining, based on the temperature change trend, that a highest estimated temperature exceeds an upper limit of a preset temperature range, limiting a charging current for the charging apparatus before an estimated temperature exceeds the upper limit of the preset temperature range.
    Type: Application
    Filed: March 21, 2024
    Publication date: July 11, 2024
    Inventors: Heping LING, Zhen ZHAI, Junhua LIU, Wei LIANG, Yulin SUN
  • Publication number: 20240132445
    Abstract: Provided is a GABAA receptor agonist phenol derivative that has a novel structure and better efficacy, can effectively reduce side effects, and is safer for clinical use. Specifically disclosed are a compound as represented by the following formula (I), a stereoisomer and pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and an application of the compound or composition of the present invention in the central nervous field, thereby providing more and better choices for medicaments for inducing and/or maintaining anesthesia in animal or human bodies, facilitating sedation and hypnosis, and treating and/or preventing anxiety, nausea, vomiting, migraine, convulsion, epilepsy, neurodegenerative diseases, and central nervous system-related diseases.
    Type: Application
    Filed: January 24, 2022
    Publication date: April 25, 2024
    Applicant: HINYE PHARMACEUTICAL CO., LTD.
    Inventors: Junhua LIU, Xueping LIANG, Haigang JIANG, Hengxin WANG, Lili DENG, Zhilin SONG
  • Publication number: 20240116387
    Abstract: A charging method includes: obtaining a first voltage of a charging port of a vehicle; determining a target buck value based on the first voltage, adjusting a voltage on a buck side of a buck-boost converter of the vehicle based on the target buck value, and sending the target buck value to a charging pile to enable the charging pile to determine an output voltage of the charging pile based on the target buck value; increasing a charging demand current of the vehicle to a maximum allowable charging current of the vehicle; and charging the vehicle according to the maximum allowable charging current.
    Type: Application
    Filed: December 14, 2023
    Publication date: April 11, 2024
    Inventors: Yubo LIAN, Heping LING, Junhua LIU, Fengjun AN, Qi WEN
  • Publication number: 20240034729
    Abstract: Disclosed by the invention is a heterocyclic compound, an intermediate, and a preparation method therefor and an application thereof. Provided by the invention are a heterocyclic compound as shown in formula I, and a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, an ester, a pharmaceutically acceptable salt or a prodrug thereof. The heterocyclic compound has a high P2X3 antagonistic activity, and has good selectivity, low toxicity, good metabolic stability and little taste influence.
    Type: Application
    Filed: December 27, 2019
    Publication date: February 1, 2024
    Inventors: Jun LOU, Yongkai CHEN, Junhua LIU, Yihan ZHANG, Xiaodan GUO, Li LIU, Lina QIAN, Chaodong WANG
  • Patent number: 11694041
    Abstract: A discourse-level text translation method and device, the method comprising: acquiring a text to be translated, the text to be translated being a unit text in a discourse-level text to be translated (S101); acquiring an associated text of the text to be translated, the associated text including at least one of a preceding source text, a following source text, and a preceding target text (S102); and translating, according to the associated text, the text to be translated (S103).
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: July 4, 2023
    Assignee: IFLYTEK CO., LTD.
    Inventors: Zhiqiang Ma, Junhua Liu, Si Wei, Guoping Hu
  • Publication number: 20230092789
    Abstract: Battery systems according to embodiments of the present technology may include a battery including a first electrode terminal and a second electrode terminal accessible along a first surface of the battery. The battery may define a recessed portion of the battery along the first surface of the battery between the first electrode terminal and the second electrode terminal. The battery systems may include a module electrically coupled with the battery. The module may include a circuit board. The module may include a first conductive tab extending from a second surface of the circuit board opposite the first surface of the circuit board. The first conductive tab may be electrically coupling the module with the first electrode terminal. The module may include a second conductive tab extending from the second surface of the circuit board. The second conductive tab may be electrically coupling the module with the second electrode terminal.
    Type: Application
    Filed: September 21, 2021
    Publication date: March 23, 2023
    Applicant: Apple Inc.
    Inventors: Hirotsugu Oba, Brian K. Shiu, Michael P. Zhang, Xiao Liu, Christopher R. Pasma, Steven M. Labovitz, Katharine R. Chemelewski, Erik D. Gillow, Joshua Walter, Junhua Liu, Michael H. Tsai, Stephan P. Abdo
  • Publication number: 20230068538
    Abstract: Disclosed by the invention is a heterocyclic compound, an intermediate, and a preparation method therefor and an application thereof. Provided by the invention are a heterocyclic compound as shown in formula I, and a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, an ester, a pharmaceutically acceptable salt or a prodrug thereof. The heterocyclic compound has a high P2X3 antagonistic activity, and has good selectivity, low toxicity, good metabolic stability and little taste influence.
    Type: Application
    Filed: December 27, 2019
    Publication date: March 2, 2023
    Inventors: Jun LOU, Yongkai CHEN, Junhua LIU, Yihan ZHANG, Xiaodan GUO, Li LIU, Lina QIAN, Chaodong WANG
  • Publication number: 20220356483
    Abstract: Provided are isolated polynucleotides and recombinant DNA constructs encoding polypeptides useful for conferring accelerated or delayed flowering time and/or maturity. Compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs are also provided.
    Type: Application
    Filed: September 18, 2019
    Publication date: November 10, 2022
    Applicants: PIONEER OVERSEAS CORPORATION, SINOBIOWAY BIO-AGRICULTURE GROUP CO. LTD.
    Inventors: GUIHUA LU, GUANGWU CHEN, HAILONG CHEN, JIAN CHEN, HUANHUAN DING, RONGRONG JIAO, HAIYAN LIU, JUNHUA LIU, GUANFAN MAO, XUEYA QIAN, CHAO SONG, CHANGGUI WANG, GUOKUI WANG, WEI WANG, XIPING WANG, YU ZHANG, YUZHEN ZHENG
  • Patent number: 11476493
    Abstract: Aspects of the present disclosure involve various battery can designs. In general, the battery can design includes two fitted surfaces oriented opposite each other and seam welded together to form an enclosure in which a battery stack is located. To form the enclosure, the two fitted surfaces are welded together along the large perimeter. Other swelling-resisting advantages may also be achieved utilizing the battery can design described herein including, but not limited to, the ability to modify one or more can wall thicknesses to control a pressure applied to the battery stack by the can, overall reduction in wall thickness of the can through the use of stronger materials for the can surfaces, additional supports structures included within the can design, and/or bossing or other localized thinning of surfaces of the can.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: October 18, 2022
    Assignee: Apple Inc.
    Inventors: Christopher R. Pasma, Siddharth Mohapatra, George V. Anastas, Bookeun Oh, YooEup Hyung, Brian K. Shiu, Haran Balaram, Junhua Liu
  • Publication number: 20220290169
    Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring delayed or accelerated flowering time and maturity. Compositions (such as plants or seeds) comprise these recombinant DNA constructs; and methods utilize these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode late flowering polypeptides.
    Type: Application
    Filed: August 19, 2019
    Publication date: September 15, 2022
    Applicants: PIONEER OVERSEAS CORPORATION, SINOBIOWAY BIO-AGRICULTURE GROUP CO. LTD.
    Inventors: GUIHUA LU, GUANGWU CHEN, RONGRONG JIAO, JUNHUA LIU, GUANFAN MAO, CHAO SONG, CHANGGUI WANG, GUOKUI WANG, WEI WANG, XIPING WANG, YUZHEN ZHENG, ZHANCHUN ZHOU
  • Publication number: 20220275384
    Abstract: Provided are suppression DNA constructs and CRISPR/Cas9 DNA constructs are useful for conferring improved drought tolerance, yield. Compositions (such as plants or seeds) comprising these constructs; and methods utilize these constructs.
    Type: Application
    Filed: September 2, 2019
    Publication date: September 1, 2022
    Applicants: PIONEER OVERSEAS CORPORATION, SINOBIOWAY BIO-AGRICULTURE GROUP CO. LTD.
    Inventors: GUIHUA LU, GUANGWU CHEN, ZANTANG LI, JUNHUA LIU, GUANFAN MAO, YANLONG SHI, CHANGGUI WANG, GUOKUI WANG, YU ZHANG
  • Publication number: 20220275382
    Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring delayed or accelerated flowering time and/or maturity. Compositions (such as plants or seeds) comprise these recombinant DNA constructs; and methods utilize these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode late flowering polypeptides.
    Type: Application
    Filed: August 28, 2019
    Publication date: September 1, 2022
    Applicants: PIONEER OVERSEAS CORPORATION, SINOBIOWAY BIO-AGRICULTURE GROUP CO. LTD.
    Inventors: GUIHUA LU, GUANGWU CHEN, HAILONG CHEN, JIAN CHEN, RONGRONG JIAO, JUNHUA LIU, GUANFAN MAO, CHAO SONG, CHANGGUI WANG, GUOKUI WANG, WEI WANG, XIPING WANG, YU ZHANG, YUZHEN ZHENG, ZHANCHUN ZHOU
  • Patent number: D968075
    Type: Grant
    Filed: March 16, 2022
    Date of Patent: November 1, 2022
    Inventor: Junhua Liu