Abstract: Provided is a supersonic aircraft including: a shield that shields an engine exhaust flow discharged from a jet engine accommodated in an engine nacelle mounted on a fuselage of the aircraft to thereby reduce sonic booms due to the engine exhaust flow; and an exhaust nozzle that is provided in an exhaust port of the engine nacelle and that generates a sound source for high-frequency components at a position at which the shield is capable of shielding the high-frequency components of the engine exhaust flow, to thereby reduce jet noise having the high-frequency components, and promotes mixing of the engine exhaust flow that generates low-frequency noise components with an external air flow to thereby reduce jet noise having the low-frequency components.

Abstract: Provided is an exhaust nozzle and a method for changing an exhaust flowpath, whereby noise can be reduced by using a simple and light-weight mechanism without increasing the complexity and size of the structure of the exhaust nozzle, and furthermore, the efficiency during cruising at supersonic speeds can be improved. The rear end side of main nozzle pieces 110 of an exhaust nozzle 100 are provided swingably in an inward and outward direction of an exhaust flow path 101, about an open/close bend section 111 to the rear of an engine, coupling nozzle pieces 120 are coupled bendably to adjacent main nozzle pieces 110 on either side, and when the main nozzle pieces 110 are swung inside the exhaust flow path 101, the coupling nozzle pieces 120 form projecting sections 102 inside the exhaust flow path 101.

Abstract: Two types of antibodies (35-1 antibody and 292 antibody) capable of binding to phenylalanine at position 115, isoleucine at position 117, glycine at position 140, glutamic acid at position 141, and arginine at position 142 of a human HB-EGF protein were successfully obtained. Then, it was also found that these antibodies had an activity of suppressing cleavage of the human HB-EGF protein, and an activity of suppressing EGFR phosphorylation that would occur when the human HB-EGF bound to the EGFR. Further, determined were amino acid sequences of light chain and heavy chain variable regions of these antibodies and sequences of CDRs of each of the variable regions.

Abstract: Two types of antibodies (35-1 antibody and 292 antibody) capable of binding to phenylalanine at position 115, isoleucine at position 117, glycine at position 140, glutamic acid at position 141, and arginine at position 142 of a human HB-EGF protein were successfully obtained. Then, it was also found that these antibodies had an activity of suppressing cleavage of the human HB-EGF protein, and an activity of suppressing EGFR phosphorylation that would occur when the human HB-EGF bound to the EGFR. Further, determined were amino acid sequences of light chain and heavy chain variable regions of these antibodies and sequences of CDRs of each of the variable regions.

Abstract: Provided is an exhaust nozzle and a method for changing an exhaust flowpath, whereby noise can be reduced by using a simple and light-weight mechanism without increasing the complexity and size of the structure of the exhaust nozzle, and furthermore, the efficiency during cruising at supersonic speeds can be improved. The rear end side of main nozzle pieces 110 of an exhaust nozzle 100 are provided swingably in an inward and outward direction of an exhaust flow path 101, about an open/close bend section 111 to the rear of an engine, coupling nozzle pieces 120 are coupled bendably to adjacent main nozzle pieces 110 on either side, and when the main nozzle pieces 110 are swung inside the exhaust flow path 101, the coupling nozzle pieces 120 form projecting sections 102 inside the exhaust flow path 101.