Abstract: Disclosed is a phosphorylation inhibitor of SMAD2/3 protein or a therapeutic agent for fibrosis which contains as an active ingredient, a nucleic acid that suppresses NEK6 (NIMA-related serine/threonine kinase 6) gene expression.

Abstract: Disclosed is an antisense nucleic acid that suppresses NEK6 gene expression.

Abstract: Disclosed is a phosphorylation inhibitor of SMAD2/3 protein or a therapeutic agent for fibrosis which contains as an active ingredient, a nucleic acid that suppresses NEK6 (NIMA-related serine/threonine kinase 6) gene expression.

Abstract: In a bogie frame, a lateral beam disposed in the left-right direction which is the direction in which the rail ties extend is joined to left and right side beams arranged so as to extend in the front-rear direction which is the direction in which the rails extend. The lateral beam has a flat shape having a width in the front-rear direction greater than the thickness thereof in the top-bottom direction, and the lateral beam is provided with left and right joining sections joined to the side beams, and also with an intermediate section sandwiched between the left and right joining sections. The width of the intermediate section in the front-rear direction is greater than the width of the joining sections in the front-rear direction. A through-hole is formed in the intermediate section.

Abstract: In a bogie frame, a lateral beam disposed in the left-right direction which is the direction in which the rail ties extend is joined to left and right side beams arranged so as to extend in the front-rear direction which is the direction in which the rails extend. The lateral beam has a flat shape having a width in the front-rear direction greater than the thickness thereof in the top-bottom direction, and the lateral beam is provided with left and right joining sections joined to the side beams, and also with an intermediate section sandwiched between the left and right joining sections. The width of the intermediate section in the front-rear direction is greater than the width of the joining sections in the front-rear direction. A through-hole is formed in the intermediate section.

Abstract: An isocyanate has been widely used as a starting material for the production of a polyurethane material, a polyisocyanurate material or the like which is suitably applicable to the field of optical materials. Disclosed is a process for producing an isocyanate which includes a step for producing the isocyanate in the form of a hydrochloride with improved productivity. A process for producing a linear or cyclic aliphatic isocyanate comprising the step of reacting a linear or cyclic aliphatic amine with hydrogen chloride to yield a hydrochloride of the linear or cyclic aliphatic amine, the step being performed under a pressure higher by 0.01 MPa or more than the atmospheric pressure.

Abstract: Provided herein are benzoxazinone compounds of formula I and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of serine hydrolase, including neutrophil elastase. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of serine hydrolase-mediated diseases.

Abstract: A piston with a built-in seal comprises a piston body (121) formed of a metal press-formed part and axially movably disposed in a clutch cylinder (110) and seal lips (122, 123) formed integrally with the piston body (121). A through tubular guide projection (124) is formed on the piston body (121). A return spring (150) for biasing the piston body (121) toward the pressurizing chamber (A) side is held on the guide projection (124). Since the press-formed through tubular guide projection (124) is higher in projecting height than the bottomed tubular one, the length over which the return spring (150) is held is longer. A pressurizing chamber (A) is prevented from being opened by the guide projection (124).

Abstract: An isocyanate has been widely used as a starting material for the production of a polyurethane material, a polyisocyanurate material or the like which is suitably applicable to the field of optical materials. Disclosed is a process for producing an isocyanate which includes a step for producing the isocyanate in the form of a hydrochloride with improved productivity. A process for producing a linear or cyclic aliphatic isocyanate comprising the step of reacting a linear or cyclic aliphatic amine with hydrogen chloride to yield a hydrochloride of the linear or cyclic aliphatic amine, the step being performed under a pressure higher by 0.01 MPa or more than the atmospheric pressure.

Abstract: Provided herein are benzoxazinone compounds of formula I and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of serine hydrolase, including neutrophil elastase. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of serine hydrolase-mediated diseases.