Abstract: The present invention provides a nucleic acid which encodes an adeno-associated virus (AAV) capsid protein mutant that contains a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID Nos. 15 to 62 or a peptide comprising an amino acid sequence produced by substituting, deleting, inserting and/or adding one or several amino acid residues in an amino acid sequence selected from the group consisting of SEQ ID Nos. 15 to 62; DNA comprising the nucleic acid; a cell harboring the DNA; and a method for producing the cell.

Abstract: A toner which is less likely to cause toner leakage and which is less likely to cause aggregation after being left to stand under a high temperature condition. A toner for developing electrostatic images, comprising colored resin particles comprising a binder resin and a colorant, and an external additive, wherein a conditioned bulk density obtained by a powder flowability analyzing device is from 0.525 g/mL to 0.565 g/mL.

Abstract: The present invention is to provide a toner production method configured to prevent scale formation, be resistant to pipe clogging, and realize stable and efficient toner production, even in the case of long-term continuous production. Disclosed is a toner production method comprising: a dispersing step for obtaining a colorant dispersion by, in a stirring tank, (a) dispersing or dissolving a colorant and a charge control agent in a polymerizable monomer, or (b) dispersing or dissolving a binder resin, a colorant and a charge control agent in an organic solvent, and a droplets forming step by suspending the colorant dispersion in an aqueous dispersion medium, wherein, in the dispersing step, the binder resin, colorant or charge control agent is added to the polymerizable monomer or organic solvent in the stirring tank, from a hopper, through a pipe heated by a heating device.

Abstract: A toner which is less likely to cause toner leakage and which is less likely to cause aggregation after being left to stand under a high temperature condition. A toner for developing electrostatic images, comprising colored resin particles comprising a binder resin and a colorant, and an external additive, wherein a conditioned bulk density obtained by a powder flowability analyzing device is from 0.525 g/mL to 0.565 g/mL.

Abstract: The present invention is to provide a toner production method configured to prevent scale formation, be resistant to pipe clogging, and realize stable and efficient toner production, even in the case of long-term continuous production. Disclosed is a toner production method comprising: a dispersing step for obtaining a colorant dispersion by, in a stirring tank, (a) dispersing or dissolving a colorant and a charge control agent in a polymerizable monomer, or (b) dispersing or dissolving a binder resin, a colorant and a charge control agent in an organic solvent, and a droplets forming step by suspending the colorant dispersion in an aqueous dispersion medium, wherein, in the dispersing step, the binder resin, colorant or charge control agent is added to the polymerizable monomer or organic solvent in the stirring tank, from a hopper, through a pipe heated by a heating device.

Abstract: A method for producing a polymerized toner comprising a step of polymerizing a polymerizable monomer composition in an aqueous dispersion medium in the presence of a polymerization initiator to obtain a dispersion liquid of colored polymer particles and a stripping step of injecting a gas comprised of air or an inert gas into the dispersion liquid of the colored polymer particles while stirring the dispersion liquid in an evaporator and the flow rate of the gas injected per weight of the colored polymer particles being 0.05 to 4 L/(hr·kg), the pressure of the vapor phase of the evaporator being 5 to 80 kPa.

Abstract: A production process of a polymerized toner, in which a corrosion-resistant metal container, the surface roughness Ry of an inner wall of which is at most 3 ?m, is used as a polymerization container, and when an aqueous liquid dispersion is heated in the polymerization container to conduct polymerization, the temperature of the aqueous liquid dispersion is raised up to a temperature 5° C. lower than a target polymerization temperature at a heating rate of 20 to 60° C./hr and raised up to the target polymerization temperature from the temperature 5° C. lower than the target polymerization temperature at a heating rate of 5 to 30° C./hr, and after the temperature of the aqueous liquid dispersion reaches the target polymerization temperature, the polymerization is conducted while controlling the temperature of the aqueous liquid dispersion so as to fall within a range of (the target polymerization temperature ±3° C.).

Abstract: A method for producing a polymerized toner comprising a step of polymerizing a polymerizable monomer composition in an aqueous dispersion medium in the presence of a polymerization initiator to obtain a dispersion liquid of colored polymer particles and a stripping step of injecting a gas comprised of air or an inert gas into the dispersion liquid of the colored polymer particles while stirring the dispersion liquid in an evaporator and the flow rate of the gas injected per weight of the colored polymer particles being 0.05 to 4 L/(hr·kg), the pressure of the vapor phase of the evaporator being 5 to 80 kPa.