Abstract: The present invention relates to a polynucleotide, containing a translated region from a start codon to a stop codon, a 5? untranslated region, and a poly A chain, in which 65% or more of nucleotides contained in the poly A chain are sugar-modified nucleotides.

Abstract: An object of the present invention is to provide a polynucleotide having a modification site in a translated region with translation activity retained. The object can be achieved by a polynucleotide containing a translated region from a start codon to a stop codon, in which the translated region contains n codons, and the n is a positive integer of 2 or more, each of the n codons contains first, second and third nucleotides, and the first nucleotides in at least two codons of the n codons are sugar modified nucleotides.

Abstract: The present invention provides, for example, an oligonucleotide derivative or a salt thereof comprising a circular oligonucleotide and a linear oligonucleotide, wherein the circular oligonucleotide and the linear oligonucleotide have base sequences complementary to each other, and form a complex via a hydrogen bond between the complementary base sequences, and a method for producing the same.

Abstract: A furnace monitoring device for monitoring the inside of a gasifier through which a combustible gas flows is provided with: a nozzle that has an internal cavity, and that is inserted inside the gasifier and fixed to the gasifier; a cylindrical protection tube which is inserted into the nozzle, and a part of which, located on the inside of the gasifier is, blocked; a monitoring window which is provided on the protection tube on the inside of the gasifier, and is made of a material that transmits light; a purge mechanism which supplies a gas containing an oxidizer to a surface of the monitoring window facing the inside of the gasifier; and an image capturing means which captures an image of the inside of the gasifier through the monitoring window.

Abstract: An oligonucleotide having improved affinity for AGO2 is disclosed. The oligonucleotide has a nucleotide residue or a nucleoside residue represented by formula (I) wherein X1 is an oxygen atom or the like, R1 is formula (IIA), wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like, or formula (IVA) wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like, or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like at the 5? end thereof, and the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3. A method for improving the knockdown activity of an oligonucleotide wherein the oligonucleotide has a knockdown activity against an mRNA encoding a protein involved in a disease.

Abstract: An oligonucleotide having a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X1 is an oxygen atom or the like, R1 is formula (IIA) (wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like), formula (IVA) (wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like), or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like, or formula (VI) (wherein n2 is 1, 2 or 3)} at the 5? end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3, is provided.

Abstract: Provided are a char feeding hopper that makes it possible to accurately measure char, a char recovery system, and a coal gasification combined power generation system. The char feeding hopper comprises: a char feeding hopper body that feeds separated char to a coal gasifier side; at least two casing tubes (121, 122) that are inserted from a side wall of the char feeding hopper body and that are provided so as to be aligned with one another in the vertical axis direction; a radiation source section (101) that is provided within the casing tube (121) and that emits ?-rays within the char feeding hopper body; and a ?-ray detector that is provided within the casing tube (122) and that detects emitted ?-rays. The cross-section of each casing tube (121, 122) has a shape that is provided with a tapered section (200) having an apex angle on the upper edge thereof.

Abstract: A furnace monitoring device for monitoring the inside of a gasifier through which a combustible gas flows is provided with: a nozzle that has an internal cavity, and that is inserted inside the gasifier and fixed to the gasifier; a cylindrical protection tube which is inserted into the nozzle, and a part of which, located on the inside of the gasifier is, blocked; a monitoring window which is provided on the protection tube on the inside of the gasifier, and is made of a material that transmits light; a purge mechanism which supplies a gas containing an oxidizer to a surface of the monitoring window facing the inside of the gasifier; and an image capturing means which captures an image of the inside of the gasifier through the monitoring window.

Abstract: The present invention provides an oligonucleotide derivative having, at an oxygen atom of at least one phosphate group of an oligonucleotide, a group represented by formula (I): (wherein R1 represents lower alkyl or the like; and R2 and R3 are the same or different and respectively represent an electron-withdrawing group or the like), or a salt thereof.

Abstract: An oligonucleotide having a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X1 is an oxygen atom or the like, R1 is formula (IIA) (wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like), formula (IVA) (wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like), or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like, or formula (VI) (wherein n2 is 1, 2 or 3)} at the 5? end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3, is provided.

Abstract: A pipe joining structure adapted to join a pipe to a fluid passage of an equipment housing. An end portion of a pipe is bent by about 90 degrees to form a bend portion and a tip of the bend portion is fitted into an opening of the fluid passage. The pipe joining structure includes a stay fitted over the bend portion of the pipe, a tip of the pipe is formed with a flange, and an O-ring fitted between the stay and the flange of the pipe. The tip of the pipe is joined to the equipment housing by fixing the stay to the equipment housing.

Abstract: A locking member for locking a rod in a path for the rod to pass through, wherein the path is formed to have a substantially heart shape, wherein the locking member includes a speed regulation path portion for regulating entrance speed by causing the rod that enters the path to fluctuate, and a locking portion for locking the rod whose entering speed is regulated, wherein the speed regulation path portion extends in a vertical direction that is perpendicular to a width direction of the locking member, and the speed regulation path portion includes rod receiving portions that are disposed at a start edge and an end edge, wherein the rod receiving portions are for regulating the entering speed by receiving the fluctuation in a forward and backward direction of the rod that enters the speed regulation path portion.

Abstract: According to one embodiment, there is provided a luminaire including a light-emitting element and a cover provided on an irradiation side of the light-emitting element. The cover includes a first light transmitting section provided on the center side of the cover and a second light transmitting section provided at the peripheral edge of the first light transmitting section and having light transmittance higher than the light transmittance of the first light transmitting section.

Abstract: A locking member for locking a rod in a path for the rod to pass through, wherein the path is formed to have a substantially heart shape, wherein the locking member includes a speed regulation path portion for regulating entrance speed by causing the rod that enters the path to fluctuate, and a locking portion for locking the rod whose entering speed is regulated, wherein the speed regulation path portion extends in a vertical direction that is perpendicular to a width direction of the locking member, and the speed regulation path portion includes rod receiving portions that are disposed at a start edge and an end edge, wherein the rod receiving portions are for regulating the entering speed by receiving the fluctuation in a forward and backward direction of the rod that enters the speed regulation path portion.

Abstract: Provided are a char feeding hopper that makes it possible to accurately measure char, a char recovery system, and a coal gasification combined power generation system. The char feeding hopper comprises: a char feeding hopper body that feeds separated char to a coal gasifier side; at least two casing tubes (121, 122) that are inserted from a side wall of the char feeding hopper body and that are provided so as to be aligned with one another in the vertical axis direction; a radiation source section (101) that is provided within the casing tube (121) and that emits ?-rays within the char feeding hopper body; and a ?-ray detector that is provided within the casing tube (122) and that detects emitted ?-rays. The cross-section of each casing tube (121, 122) has a shape that is provided with a tapered section (200) having an apex angle on the upper edge thereof.

Abstract: The present invention provides an oligonucleotide having improved affinity for AGO2, and the like. The oligonucleotide has a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X1 is an oxygen atom or the like, R1 is formula (IIA) (wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like) or formula (IVA) (wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like), or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like} at the 5? end thereof, and the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3.

Abstract: A pipe joining structure adapted to join a pipe to a fluid passage of an equipment housing. An end portion of a pipe is bent by about 90 degrees to form a bend portion and a tip of the bend portion is fitted into an opening of the fluid passage. The pipe joining structure includes a stay fitted over the bend portion of the pipe, a tip of the pipe is formed with a flange, and an O-ring fitted between the stay and the flange of the pipe. The tip of the pipe is joined to the equipment housing by fixing the stay to the equipment housing.

Abstract: A pipe joining structure adapted to join a pipe to a fluid passage of an equipment housing. An end portion of a pipe is bent by about 90 degrees to form a bend portion and a tip of the bend portion is fitted into an opening of the fluid passage. The pipe joining structure includes a stay fitted over the bend portion of the pipe, a tip of the pipe is formed with a flange, and an O-ring fitted between the stay and the flange of the pipe. The tip of the pipe is joined to the equipment housing by fixing the stay to the equipment housing.

Abstract: According to one embodiment, there is provided a luminaire including a light-emitting element and a cover provided on an irradiation side of the light-emitting element. The cover includes a first light transmitting section provided on the center side of the cover and a second light transmitting section provided at the peripheral edge of the first light transmitting section and having light transmittance higher than the light transmittance of the first light transmitting section.

Abstract: An oligonucleotide, which has a nucleotide residue or a nucleoside residue represented by formula (I) at the 5? end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue via the oxygen atom at position 3, or the like; wherein X represents an oxygen atom or the like, R1 represents formula (II) wherein Y1 represents a nitrogen atom or the like, R5 represents halogen or the like, R6 and R7 may be the same or different, and each represents a hydrogen atom or the like, and R3 represents a hydrogen atom or the like.