Abstract: [Object] It is an object of the present invention to provide a conjugate of a biotin-modified dimer and a phthalocyanine dye, which is used in photoimmunotherapy. [Means for Solution] A compound represented by the following formula (1) or a salt thereof: wherein X represents a substituent having a hydrophilic group, a cationic group or an amino group at the terminus thereof, or —OH, and other groups have the meanings as defined in the description.

Abstract: [Object] To provide a fusion protein of an antibody that recognizes cancer cells and a mutant streptavidin, which is for use in the treatment or diagnosis of cancer. [Means for Solution] A fusion protein comprising a protein-recognizing substance and the amino acid sequence as set forth in SEQ ID NO: 19 that is fused with the protein-recognizing substance.

Abstract: It is intended to provide a digital planetarium picture-projecting apparatus capable of recording and executing an operation procedure, facilitating recording of the operation procedure, editing the operation procedure, and executing an ad-lib representation when the operation procedure is executed. The digital planetarium picture projecting apparatus comprises an operating portion which accepts an operation by an operator about picture projection, an operation display panel which displays information about picture projection to the operator, a manual process recording portion which records an operation procedure executed to the operating portion, and a control portion which executes picture projection according to the operation procedure recorded in the manual process recording portion, wherein a temporary stop or restart operation by the operator is accepted during recording of the operation procedure by the manual process recording portion.

Abstract: A radioactive isotope-labeled dye compound represented by the following general formula (I): wherein R1 and R2 represent a substituent, R3 to R6 represent a substituted or unsubstituted alkyl group; R7 and R8 represent a substituted or unsubstituted alkyl group; L1 to L3 represent a substituted or unsubstituted methine group; r represents an integer of 0 to 3; P and Q represent 123I, 124I, 125I, 131I or 18F; M represents hydrogen atom, Na, or K; and m and n represent an integer of 0 to 2.

Abstract: A radioactive isotope-labeled dye compound represented by the following general formula (I): wherein R1 and R2 represent a substituent, R3 to R6 represent a substituted or unsubstituted alkyl group; R7 and R8 represent a substituted or unsubstituted alkyl group; L1 to L3 represent a substituted or unsubstituted methine group; r represents an integer of 0 to 3; P and Q represent 123I, 124I, 125I, 131I or 18F; M represents hydrogen atom, Na, or K; and m and n represent an integer of 0 to 2.

Abstract: A compound having superior solubility and suitable for a liposome contrast medium selective for a lesion such as vascular diseases is provided which is represented by the following general formula (I) wherein R1 to R3 represent an alkyl group or alkenyl group; X1 and X2 represent a single bond, —O—, or —N(Z1)- (Z1 represents hydrogen atom, or an alkyl group); X3 to X6 represent —O—, or —N(Z2)- (Z2 represents hydrogen atom, or an alkyl group); n represents an integer of 1 to 10; and L represents a divalent bridging group constituted by atoms selected from the group consisting of carbon atom, hydrogen atom, oxygen atom, nitrogen atom, fluorine atom and sulfur atom.

Abstract: A digital planetarium apparatus includes an original image generator, an intermediate image generator, and a fish-eye lens. The original image generator is formed of two video projectors and generates semicircular images in display devices inside the respective video projectors. The intermediate image generator optically focuses the two semicircular images generated by the original image generator to thereby generate a circular image. The fish-eye lens projects the circular image generated by the intermediate image generator.

Abstract: An image processing apparatus for outputting an image by a printer or a display is provided, in which color reproducibility in the image output of plural pages becomes uniform. The apparatus comprises an image memory for memorizing image data of all pages of one output job that is given to an output device, decision portion for deciding whether the image data of all pages are data within a color reproduction range of the output device or not. A color compression process is performed for the image data of all pages uniformly only when it is decided that the image data of all pages are not data within the color reproduction range of the output device.

Abstract: An image processing apparatus is provided in which the frequency of undesired delay of the image output can be reduced. The image processing apparatus comprises an image processor for performing a process defined by a parameter on the image data of the received job, a decision portion for deciding a state of the image data of the received job, and a controller for setting a parameter in accordance with the state that is decided by the decision portion if an interval between the received job and the previously received job is longer than a predetermined time, and for setting the parameter that was used in the last job despite the state that is decided by the decision portion if the interval is not longer than the predetermined time.

Abstract: A compound having superior solubility and suitable for a liposome contrast medium selective for a lesion such as vascular diseases is provided which is represented by the following general formula (I) wherein R1 to R3 represent an alkyl group or alkenyl group; X1 and X2 represent a single bond, —O—, or —N(Z1)- (Z1 represents hydrogen atom, or an alkyl group); X3 to X6 represent —O—, or —N(Z2)- (Z2 represents hydrogen atom, or an alkyl group); n represents an integer of 1 to 10; and L represents a divalent bridging group constituted by atoms selected from the group consisting of carbon atom, hydrogen atom, oxygen atom, nitrogen atom, fluorine atom and sulfur atom.

Abstract: A liposome containing a phosphatidylcholine and a phosphatidylserine in combination as membrane components at a phosphatidylcholine:phosphatidylserine molar ratio of 3:1 to 1:2, and said liposome containing superparamagnetic particles having a mean particle size not less than 1 nm and not more than 50 nm. A means for selectively accumulating an MRI contrast medium in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis and restenosis after PTCA is provided.

Abstract: A doped-type metal sulfide phosphor nanoparticle, whose surface is modified with a surface modifier, the surface modifier being a compound of formula [I]: HS-L-W??Formula [I] wherein L is a divalent linking group; and W is COOM or NH2, in which M is a hydrogen atom, an alkali metal atom, or NX4, in which X is a hydrogen atom or an alkyl group; a dispersion containing the nanoparticle; and a method of producing the nanoparticle or the dispersion.

Abstract: In a tomograpy apparatus: low-coherence laser light is split into measurement light and reference light; the frequency of the reference light is slightly shifted from the frequency of reflected light generated by reflection of the measurement light by a sample; the reference light is optically combined with the reflected light; interference light generated by interference of the reference light with the reflected light when the reference light is combined with the reflected light is detected: fluorescence emitted by excitation of a fluorescent dye or a fluorescent pigment in the sample when the sample is irradiated with the measurement light is detected: a first tomographic image of the sample is formed by the detected interference light, and a second tomographic image of the sample is formed by the detected fluorescence.

Abstract: A doped-type metal sulfide phosphor nanoparticle dispersion, comprising a doped-type metal sulfide phosphor nanoparticle dispersed in water and/or a hydrophilic solvent, wherein the doped-type metal sulfide phosphor nanoparticle comprises a surface that is modified with a surface modifier, the surface modifier being a compound represented by formula [I]: HS-L-W??Formula [I] wherein L represents a divalent linking group; and W represents COOM or NH2, in which M represents a hydrogen atom, an alkali metal atom, or NX4, in which X represents a hydrogen atom or an alkyl group.

Abstract: A doped-type metal sulfide phosphor nanoparticle, whose surface is modified with a surface modifier, the surface modifier being a compound of formula [I]: HS-L-W??Formula [I] wherein L is a divalent linking group; and W is COOM or NH2, in which M is a hydrogen atom, an alkali metal atom, or NX4, in which X is a hydrogen atom or an alkyl group; a dispersion containing the nanoparticle; and a method of producing the nanoparticle or the dispersion.

Abstract: A doped-type metal sulfide phosphor nanoparticle dispersion, comprising a doped-type metal sulfide phosphor nanoparticle dispersed in a hydrophobic organic solvent, wherein the doped-type metal sulfide phosphor nanoparticle comprises a surface that is modified with a surface modifier, the surface modifier being a compound represented by formula [I]: HS-L-WFormula [I] wherein L represents a divalent linking group; and W represents COOM or NH2, in which M represents a hydrogen atom, an alkali metal atom, or NX4, in which X represents a hydrogen atom or an alkyl group.

Abstract: Two or more target substances are simply and efficiently detected using one type of nanoparticle. Two or more target substances contained in one sample are labeled with two or more fluorescent dyes each capable of binding to the respective target substance and each of which emit light at wavelengths different from each other, combination is made with a phosphor nano-particle capable of binding to each of the two or more fluorescent dyes, subsequently irradiation is undertaken with an excitation light which excites the phosphor nano-particle to emit light, and the two or more fluorescent dyes are caused to emit fluorescence using the light from the phosphor nano-particle as an excitation light.

Abstract: The invention provides a fluorescence detecting method, comprising irradiating an excitation light in the UV range on a sample containing a nanoparticle fluorescent material having an emission half-value width of 50 nm to 200 nm as the fluorescent material and detecting the fluorescence emitted from the sample in the visible range.

Abstract: A liposome containing a hydrophobic chelate compound as a membrane component, and an MRI contrast medium containing the liposome for use in imaging of, preferably, a vascular disease. An MRI contrast medium that accumulates in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis is provided.

Abstract: A compound represented by the following general formula (I), or a salt thereof: wherein R1 and R2 independently represent a substituted or unsubstituted alkyl or alkenyl group having 8 to 30 carbon atoms; L represents a divalent bridging group (L is constituted by atoms selected from the group consisting of carbon atom, oxygen atom, nitrogen atom and hydrogen atom, wherein the total number of atoms constituting L and selected from the group consisting of carbon atom, oxygen atom and nitrogen atom is 4 to 15); and Ch represents a chelate forming moiety containing 3 or more nitrogen atoms. A compound suitable for a liposome contrast medium for performing lesion-selective imaging is provided.