Patents by Inventor Junji Yoshinaga

Junji Yoshinaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150137035
    Abstract: A water absorbing material that is suitable for being discarded by being flushed down a flush toilet is provided. The water absorbing material includes only an organic substance containing no nutrients.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 21, 2015
    Inventors: Hiroshi ITO, Shinobu HATANAKA, Junji YOSHINAGA
  • Patent number: 5721109
    Abstract: A reagent for the detection of an antibody against an acid-fast bacterial antigen comprising at least one compound selected from the group comprising mycolic acids, mycolic acid salts, mycolic acid esters and esters of fatty acids having a carbon number of 14 or more other than mycolic acid with a mono- or disaccharide, a method of detecting an antibody against an acid-fast bacterial antigen using said reagent and a method of diagnosis of acid-fast bacterial infections by said detection method are simpler in procedures and offer much higher specificity in comparison with conventional reagents and methods, enabling identification of acid-fast bacterial genera (including the genera Mycobacterium, Nocardia and Rhodococcus) and acid-fast bacterial species, and thus it is possible to make diagnoses to identify the infecting acid-fast bacterium, which leads to the quick choice of therapeutic drug for the disease.
    Type: Grant
    Filed: August 23, 1993
    Date of Patent: February 24, 1998
    Assignees: Sawai Pharmaceutical Co., Ltd., Medisa Shinyaku Inc.
    Inventors: Ikuya Yano, Shiro Oka, Yoshiteru Ueno, Yayoi Natsuhara, Junji Yoshinaga, Yoshiko Kato
  • Patent number: 5049664
    Abstract: A trehalose derivative of the formula: ##STR1## wherein one, two, three or four of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are independently selected from the group consisting of C.sub.1-40 aliphatic acyl groups and all the rest of them are hydrogen atoms,with the proviso that:a) when one of them is C.sub.1-40 aliphatic acyl group, then it is not 2-palmitoyl or 6-aliphatic acyl,b) when two of them are C.sub.1-40 aliphatic acyl groups, then they are not located at corresponding positions with each other,c) when three of them are C.sub.1-40 aliphatic acyl groups, then they are not 2,3,2'-tripalmitoyl, andd) when four of them are C.sub.1-40 aliphatic acyl groups, then they are not located at corresponding positions with each other or at 2,3,4,2'- or 2,3,6,2'-positions.The compounds of the above formula have anti-tumor activity.
    Type: Grant
    Filed: August 16, 1989
    Date of Patent: September 17, 1991
    Assignee: Sawai Pharmaceutical Co., Ltd.
    Inventors: Junji Yoshinaga, Takeshi Shogaki, Takao Kakita, Hiromi Ozeki, Yoshiko Kato
  • Patent number: 5006514
    Abstract: An .alpha.,.alpha.-trehalose trimycolate represented by formula: ##STR1## (wherein R.sup.1 through R.sup.8 each represents a hydrogen atom or mycolic acid residue, and three of R.sup.1 through R.sup.8 are mycolic acid residues; these mycolic acid residues may, or may not be identical with each other).Since the said .alpha.,.alpha.-trehalose trimycolate possesses both immunopotentiating activity and antitumor activity on animals and is low in toxicity, it is expected to be applied to a protective drug against infection of various microbes, an antitumor agent and immunopotentiation at the time of decline in physical strength.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: April 9, 1991
    Assignee: Sawai Pharmaceutical Co., Ltd.
    Inventors: Yoshiko Kato, Junji Yoshinaga, Takeshi Shogaki, Satoko Kurano, Ikuya Yano
  • Patent number: 5006548
    Abstract: Compounds of the general formula: ##STR1## wherein R.sup.1 is heterocyclic group other than pyridyl and which is unsubstituted or substituted with lower alkyl or lower alkoxycarbonyl, R.sup.2 is hydrogen, halogen, or nitro, and R.sup.3 is carboxy group or its functional derivative, with the proviso that when R.sup.1 is an unsubstituted furyl, or furyl mono- or polysubstituted with alkyl and R.sup.2 is hydrogen, then R.sup.3 is functional derivative of carboxy and, where applicable, pharmaceutically acceptable salts thereof are hyaluronidase inhibitors and useful as anti-allergic agent.
    Type: Grant
    Filed: August 7, 1989
    Date of Patent: April 9, 1991
    Assignee: Sawai Pharmaceutical Co., Ltd.
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa, Yoshiko Kato, Juichi Riku, Junji Yoshinaga, Yoshifumi Kanamoto
  • Patent number: 4946855
    Abstract: A compound of the formula: ##STR1## wherein the free valency of the groups A-, R- and --X--Y-- is attached to any of 2-, 4- and 5- positions of the thiazol ring, A is a C.sub.1-6 alkyl group, an aryl group which is unsubstituted or substituted with at least one substituent selected from the group consisting of hydroxy C.sub.1-6 alkoxy, aryl-(C.sub.1-6)alkoxy, halo-(C.sub.1-6)alkyl, halogen, and nitro,or 5- or 6-membered heterocyclic group containing at least one hetero atom selected from oxygen, nitrogen and sulfur, or a condensed heterocyclic group consisting of a heterocycle as defined above and a benzene nucleus, these two heterocyclic groups being unsubstituted or substituted with at least one substituent selected from halogen,R is hydrogen or a C.sub.
    Type: Grant
    Filed: November 28, 1988
    Date of Patent: August 7, 1990
    Assignee: Sawai Pharmaceutical Co., Ltd.
    Inventors: Junji Yoshinaga, Takeshi Shogaki, Takao Kakita, Hiromi Ozeki, Yoshiko Kato
  • Patent number: 4879295
    Abstract: Compounds of the formula: ##STR1## wherein A is a C.sub.1-6 alkyl group, an aryl group which is unsubstituted or substituted with at least one substituent selected from hydroxy, alkoxy, aryl-(C.sub.1-6)alkoxy, C.sub.1-6 alkylcarbonyloxy, halo-(C.sub.1-6)alkyl, halogen, nitro and amino,or 5- or 6-membered heterocyclic group containing at least one hetero atom selected from oxygen, nitrogen and sulfur, or a condensed heterocyclic group consisting of a heterocycle as defined above and a benzene nucleus,these two heterocyclic groups being unsubstituted or substituted with at least one substituent selected from hydroxy, C.sub.1-6 alkyl and halogen, and R is hydrogen or a C.sub.1-6 alkyl group,or a pharmaceutically acceptable salt thereof are nobel and useful as antiallergic.
    Type: Grant
    Filed: September 17, 1987
    Date of Patent: November 7, 1989
    Assignee: Sawai Pharmaceutical Co., Ltd.
    Inventors: Junji Yoshinaga, Takeshi Shoyaki, Takao Kakita, Hiromi Ozeki, Nobuko Sugimoto, Yoshiko Kato
  • Patent number: 4822791
    Abstract: This invention relates to pharmaceutical compositions of compounds of the general formula: ##STR1## wherein R.sup.1 is an aryl group or a substituted aryl group wherein the substituent is halogen, hydroxy, C.sub.(1-6) lower alkoxy, C.sub.(1-6) lower alkylenedioxy, halo C.sub.(1-6) lower alkyl, cyano, nitro, mono- or di-C.sub.(1-6) alkylamino or C.sub.(1-6) lower alkanoylamino; or a 5-membered or 6-membered C.sub.(1-6) alkyl substituted or unsubstituted heterocyclic group containing a heteroatom selected from oxygen, nitrogen, and sulfur, or a condensed heterocyclic group consisting of a heterocycle as defined above and a benzene nucleus, and R.sup.2 and R.sup.2' are, independently, hydrogen, halogen, nitro, C.sub.(1-6) lower alkyl or C.sub.(1-6) lower alkoxy. These compounds have been found to exhibit hyaluronidase inhibiting activity, anti-allergic activity and anti-ulcerous activity.
    Type: Grant
    Filed: March 2, 1988
    Date of Patent: April 18, 1989
    Assignee: Sawai Pharmaceutical Co., Ltd.
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa, Yoshiko Kato, Juichi Riku, Junji Yoshinaga, Yoshifumi Kanamoto
  • Patent number: 4755506
    Abstract: Compounds of the general formula: ##STR1## wherein A and B are both hydrogen, or one of A and B is a group (G) of the formula: ##STR2## and the other is a group R.sup.5 wherein R.sup.1 is an aryl group or a heterocyclic group, both of them being optionally substituted, and R.sup.4 and R.sup.5 are both hydrogen or together form a single chemical bond,R.sup.2 and R.sup.2 ' are independently hydrogen, halogen, nitro, lower alkyl or lower alkoxy, andR.sup.3 and R.sup.3 ' are independently carboxy or its functional derivative, with the proviso that (a) when A and B are both hydrogen, then R.sup.2 and R.sup.2 ' cannot be both hydrogen,and, where applicable, pharmaceuticably acceptable salts thereof are hyaluronidase inhibitors, and useful as anti-allergic agent and anti-ulcerous agent. Among the compound (I'), those wherein when one of A and B is the group (G) and the other is the group R.sup.5 wherein R.sup.4 and R.sup.5 together form a single chemical bond, R.sup.1 is unsubstituted aryl and R.sup.2 and R.sup.
    Type: Grant
    Filed: September 19, 1986
    Date of Patent: July 5, 1988
    Assignee: Sawai Pharmaceutical Co., Ltd.
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa, Yoshiko Kato, Juichi Riku, Junji Yoshinaga, Yoshifumi Kanamoto
  • Patent number: 4634777
    Abstract: Compounds of the general formula: ##STR1## wherein A and B are both hydrogen, or one of A and B is a group (G) of the formula: ##STR2## and the other is a group R.sup.5 wherein R.sup.1 is an aryl group or a heterocyclic group, both of them being optionally substituted, and R.sup.4 and R.sup.5 are both hydrogen or together form a single chemical bond,R.sup.2 and R.sup.2 ' are independently hydrogen, halogen, nitro, lower alkyl or lower alkoxy, andR.sup.3 and R.sup.3 ' are independently carboxy or its functional derivative, with the proviso that (a) when A and B are both hydrogen, then R.sup.2 and R.sup.2 ' cannot be both hydrogen,and, where applicable, pharmaceuticably acceptable salts thereof are hyaluronidase inhibitors, and useful as anti-allergic agent and anti-ulcerous agent. Among the compound (I'), those wherein when one of A and B is the group (G) and the other is the group R.sup.5 wherein R.sup.4 and R.sup.5 together form a single chemical bond, R.sup.1 is unsubstituted aryl and R.sup.2 and R.sup.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: January 6, 1987
    Assignee: Sawai Pharmaceutical Co., Ltd.
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa, Yoshiko Kato, Juichi Riku, Junji Yoshinaga, Yoshifumi Kanamoto