Patents by Inventor Junjing WANG

Junjing WANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis method for preparing SGLT inhibitor intermediate
    Patent number: 12448360
    Abstract: A method for preparing compound 1 and compound 2 having a structure as shown below, the method includes the following steps: 1) subjecting 2,3-dihydrobenzofuran-7-amine as a raw material to a selective-dibromination with a brominating reagent to obtain 4,6-dibromo-2,3-dihydrobenzofuran-7-amine; 2) subjecting 4,6-dibromo-2,3-dihydrobenzofuran-7-amine obtained in the step 1) to Sandmeyer reaction for chlorination to obtain 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran; 3-1) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then adding a formylation reagent to obtain compound 1; 3-2) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then reacting with 4-cyclopropyl benzaldehyde to obtain compound 2.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: October 21, 2025
    Assignee: DAEWOONG PHARMACEUTICAL CO., LTD.
    Inventors: Zhining Huang, Weiping Ye, Zhangtao Zhou, Junjing Wang, Heekyoon Yoon, Ji-Soo Choi
  • SYNTHESIS METHOD FOR PREPARING SGLT INHIBITOR INTERMEDIATE
    Publication number: 20230322699
    Abstract: A method for preparing compound 1 and compound 2 having a structure as shown below, the method includes the following steps: 1) subjecting 2,3-dihydrobenzofuran-7-amine as a raw material to a selective-dibromination with a brominating reagent to obtain 4,6-dibromo-2,3-dihydrobenzofuran-7-amine; 2) subjecting 4,6-dibromo-2,3-dihydrobenzofuran-7-amine obtained in the step 1) to Sandmeyer reaction for chlorination to obtain 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran; 3-1) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then adding a formylation reagent to obtain compound 1; 3-2) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then reacting with 4-cyclopropyl benzaldehyde to obtain compound 2.
    Type: Application
    Filed: September 10, 2020
    Publication date: October 12, 2023
    Inventors: Zhining HUANG, Weiping YE, Zhangtao ZHOU, Junjing WANG, Heekyoon YOON, Ji-Soo CHOI