Abstract: The present application relates to an indolone derivative having an IRAK4 inhibitory activity as represented by formula (I), a preparation method therefor and the use thereof, and further relates to a compound capable of inhibiting and degrading the IRAK4 protein and a pharmaceutical composition comprising the indolone derivative or the compound capable of inhibiting and degrading the IRAK4 protein.

Abstract: The present application relates to a novel IRAK4 inhibitor of formula (I) and a compound for inhibiting and degrading IRAK4 protein, a preparation method therefor and use thereof, and also relates to a pharmaceutical composition comprising the IRAK4 inhibitor or the compound for inhibiting and degrading IRAK4 protein.

Abstract: Provided are a compound or an enantiomer, diastereoisomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, or metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound, or prodrug thereof, as well as an application thereof in the treatment of a CRBN-mediated disease or disorder.

Abstract: The present application relates to a compound for inhibiting IRAK4 activity and a use thereof, and specifically provides a compound as represented by formula A, or an enantiomer, a diastereoisomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, a nitrogen oxide, a metabolite or a pharmaceutically acceptable salt, an ester, a solvate, a hydrate, an isotope-labeled compound (preferably a deuterated substance), or a prodrug thereof,

Abstract: An improved surgical apparatus actuator includes a nail bin assembly (1002), a nail anvil assembly (1001) connecting with the nail bin assembly (1002), and a drive assembly (1003) controlling the nail bin assembly (1002) and the nail anvil assembly (1001) to convert between opening and closing conditions. The nail anvil assembly (1001) includes a nail anvil plate (103) and a nail anvil seat (102), wherein the nail anvil plate (103) is provided on an inner side (1022) of the nail anvil seat (102), the nail anvil seat (102) has the structure, material and processing technology capable of providing high anti-bending performance, the nail anvil plate (103) is cold-punched from a thinner stainless steel sheet. Therefore, the processing difficulty of the components is reduced, and meanwhile, the ability of the actuator chuck to resist bending deformation is improved.

Abstract: An improved surgical apparatus actuator includes a nail bin assembly (1002), a nail anvil assembly (1001) connecting with the nail bin assembly (1002), and a drive assembly (1003) controlling the nail bin assembly (1002) and the nail anvil assembly (1001) to convert between opening and closing conditions. The nail anvil assembly (1001) includes a nail anvil plate (103) and a nail anvil seat (102), wherein the nail anvil plate (103) is provided on an inner side (1022) of the nail anvil seat (102), the nail anvil seat (102) has the structure, material and processing technology capable of providing high anti-bending performance, the nail anvil plate (103) is cold-punched from a thinner stainless steel sheet. Therefore, the processing difficulty of the components is reduced, and meanwhile, the ability of the actuator chuck to resist bending deformation is improved.