Abstract: The present disclosure provides a simplified cotton cultivation method relying on setting bolls on VBs. Not only can the method form seed cotton yield and increase the yield by at least 10% compared with conventional manual pruning or no-prune technique, but also eliminate pruning and topping. The method is a new, simple and feasible simplified cotton cultivation method. The simplified cotton cultivation method relying on setting bolls on VBs includes the following steps: heading a cotton plant to retain only VBs when cotton grows to squaring stage, namely cutting off the first fruiting branch and an upper main stem thereof from the cotton plant after squaring, and only retaining the vegetative branches for growth and development, squaring, flowering, and setting bolls.