Patents by Inventor Junke Zheng

Junke Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-LILRB antibodies and their use in detecting and treating cancer
    Patent number: 11498963
    Abstract: The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: November 15, 2022
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Chengcheng Zhang, Mi Deng, Wei Xiong, Zhiqiang An, Ningyan Zhang, Xun Gui, Junke Zheng
  • Compounds supports hematopoietic stem cells and red blood cells
    Patent number: 11013704
    Abstract: The present disclosure relates to methods of using a compound to induce regeneration of hematopoietic stem cells or increase the recovery of red blood cells. In some aspects, the present methods can be used to with or in place of erythropoietin in patients to mitigate the side effects of erythropoietin.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 25, 2021
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Chengcheng Zhang, Yi Liu, Junke Zheng, Mi Deng, Chuo Chen, Jiawei Liu
  • ANTI-LILRB ANTIBODIES AND THEIR USE IN DETECTING AND TREATING CANCER
    Publication number: 20200079851
    Abstract: The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 12, 2020
    Inventors: Chengcheng ZHANG, Mi DENG, Wei XIONG, Zhiqiang AN, Ningyan ZHANG, Xun GUI, Junke ZHENG
  • Anti-LILRB antibodies and their use in detecting and treating cancer
    Patent number: 10501538
    Abstract: The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: December 10, 2019
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Chengcheng Zhang, Mi Deng, Wei Xiong, Zhiqiang An, Ningyan Zhang, Xun Gui, Junke Zheng
  • LILRB2 AND NOTCH-MEDIATED EXPANSION OF HEMATOPOIETIC PRECURSOR CELLS
    Publication number: 20190330593
    Abstract: The current disclosure describes methods of expanding precursor cells for hematopoietic transplantation in subjects. The methods culture precursor cells in media containing an immobilized high molecular weight LILRB2 agonist or an LILRB2 agonist in combination with a Notch agonist. The expanded cells can be used to treat a variety of hematopoietic disorders.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 31, 2019
    Applicants: Fred Hutchinson Cancer Research Center, Board of Regents of the University of Texas System
    Inventors: Irwin D. Bernstein, Chengcheng Zhang, Mi Deng, Zhigang Lu, Junke Zheng
  • LILRB2 and notch-mediated expansion of hematopoietic precursor cells
    Patent number: 10370643
    Abstract: The current disclosure describes methods of expanding precursor cells for hematopoietic transplantation in subjects. The methods culture precursor cells in media containing an immobilized high molecular weight LILRB2 agonist or an LILRB2 agonist in combination with a Notch agonist. The expanded cells can be used to treat a variety of hematopoietic disorders.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: August 6, 2019
    Assignees: Fred Hutchinson Cancer Research Center, Board of Regents of the University of Texas System
    Inventors: Irwin D. Bernstein, Chengcheng Zhang, Mi Deng, Zhigang Lu, Junke Zheng
  • COMPOSITIONS AND METHODS FOR MODULATING PRO-INFLAMMATORY IMMUNE RESPONSE
    Publication number: 20180177847
    Abstract: Provided herein are compositions and methods useful for increasing a pro-inflammatory immune response, treating an autoimmune disorder, inflammation, or transplant rejection in a mammal by activating a leukocyte immunoglobulin-like receptor (LILR) protein. Also provided are compositions and methods useful for increasing a pro-inflammatory immune response, treating cancer, and treating infectious disease in a mammal by blocking the activation of a LILR protein.
    Type: Application
    Filed: December 6, 2017
    Publication date: June 28, 2018
    Inventors: Shu-Hsia CHEN, Chengcheng ZHANG, Xunlei KANG, Junke ZHENG, Masato UMIKAWA
  • ANTI-LILRB ANTIBODIES AND THEIR USE IN DETECTING AND TREATING CANCER
    Publication number: 20180086829
    Abstract: The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 29, 2018
    Inventors: Chengcheng ZHANG, Mi DENG, Wei XIONG, Zhiqiang AN, Ningyan ZHANG, Xun GUI, Junke ZHENG
  • NOVEL COMPOUNDS SUPPORTS HEMATOPOIETIC STEM CELLS AND RED BLOOD CELLS
    Publication number: 20170304240
    Abstract: The present disclosure relates to methods of using a compound to induce regeneration of hematopoietic stem cells or increase the recovery of red blood cells. In some aspects, the present methods can be used to with or in place of erythropoietin in patients to mitigate the side effects of erythropoietin.
    Type: Application
    Filed: May 12, 2015
    Publication date: October 26, 2017
    Inventors: Chengcheng ZHANG, Yi LIU, Junke ZHENG, Mi DENG, Chuo CHEN, Jiawei LIU
  • LILRB2 AND NOTCH-MEDIATED EXPANSION OF HEMATOPOIETIC PRECURSOR CELLS
    Publication number: 20170260508
    Abstract: The current disclosure describes methods of expanding precursor cells for hematopoietic transplantation in subjects. The methods culture precursor cells in media containing an immobilized high molecular weight LILRB2 agonist or an LILRB2 agonist in combination with a Notch agonist. The expanded cells can be used to treat a variety of hematopoietic disorders.
    Type: Application
    Filed: May 21, 2015
    Publication date: September 14, 2017
    Inventors: Irwin D. Bernstein, Chengcheng Zhang, Mi Deng, Zhigang Lu, Junke Zheng
  • Compositions And Methods For Modulating Pro-Inflammatory Immune Response
    Publication number: 20150174203
    Abstract: Provided herein are compositions and methods useful for increasing a pro-inflammatory immune response, treating an autoimmune disorder, inflammation, or transplant rejection in a mammal by activating a leukocyte immunoglobulin-like receptor (LILR) protein. Also provided are compositions and methods useful for increasing a pro-inflammatory immune response, treating cancer, and treating infectious disease in a mammal by blocking the activation of a LILR protein.
    Type: Application
    Filed: May 30, 2013
    Publication date: June 25, 2015
    Inventors: Shu-Hsia Chen, Chengcheng Zhang, Xunlei Kang, Junke Zheng, Masato Umikawa