Abstract: An estimation device (10) receives a device ID for identifying a device in a network and an observation event that has occurred in the device from a user terminal (20) as an input. The estimation device (10) acquires attribute information of the device corresponding to the received device ID from a device information storage unit (13c), estimates a risk that the device in the network is subject to an attack on the basis of the acquired attribute information and the received observation event, and outputs the estimated attack risk to the user terminal (20).

Abstract: An support system server (100) accepts, for each board related to crisis response activity, browsing of one or more messages registered in the board and registration of a message in the board. When a transmission source of a received e-mail is an e-mail address of a user of the board, the support system server (100) registers a message included in the e-mail in the board. When a new message is registered in the board, the support system server (100) distributes an e-mail including the message to the e-mail address of the user of the board.

Abstract: A server (10) stores a task ID of information on a task that is viewed by a client terminal (20) and a screen shot when the client terminal (20) logs out from the server (10) as a user activity log of the client terminal (20). In addition, when the client terminal (20) logs into the server (10) once again, the server (10) refers to the user activity log of the client terminal (20) and displays a screen shot upon a previous logout. Furthermore, the server (10) refers to a task ID included in the user activity log of the client terminal (20) and displays unread tasks of the client terminal (20).

Abstract: A management apparatus (20) includes: a storage unit (21) which stores user attribute information that associates a user who manages information related to crises and an attribute of the user with each other, correspondence information that associates the attribute and an external system of which the attribute is login-enabled with each other, and login information with respect to each external system; an external login information processing unit (223) which, when receiving a login request to an external system from a user, refers to the user attribute information, the correspondence information, and the login information stored in the storage unit, acquires an attribute of the user, and acquires information on an external system to which the acquired attribute is login-enabled; and an external login processing unit (224) which executes a login to an external system to which a login has been requested among the login-enabled external systems.

Abstract: The purpose of the present invention is to provide a novel compound which has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare that are causative bacteria of MAC infection and which is different in backbone structure from known drugs for treatment of MAC infection. One aspect of the present invention relates to a compound of Formula (I) [where R1 has the same meaning as described in the specification and claims] or a salt thereof, or a solvate thereof. Another aspect of the present invention relates to a method for producing the compound of Formula (I) or a salt thereof, or a solvate thereof, and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), which comprises the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient.

Abstract: Based on a presentation rule in which a DB to be searched, a search condition, and a user terminal targeted for presentation are set, a support device transmits, to a management device, a know-how search request including a search condition corresponding to a presentation type in a presentation request according to the presentation type indicating which business the presentation of know-how is requested for. The support device integrates returned pieces of know-how information, and presents the integrated know-how information to a user terminal. The management device searches, if the requester is allowed to access the DB to be searched based on control information in which a DB to be disclosed and a type of know-how information are associated with disclosure destination information indicating a destination for disclosure.

Abstract: The present invention provides a method for producing a modified compound, including the following steps: (1) a step of cleaving in vitro using a CRISPR/Cas9 system, a target site in a gene cluster involved in the biosynthesis of a compound, (2) a step of connecting using Gibson assembly in vitro the gene cluster cleaved in step (1) and a polynucleotide for modification, and (3) a step of expressing the modified gene cluster obtained in step (2) in a microorganism expression system.

Abstract: A server (10) that manages a plurality of boards refers to, when a similarity between a message Ax of a board A and a message Bx of a board B is equal to or greater than a prescribed value, information disclosable range information of each board, and when it is determined that boards capable of disclosing a message of the board B includes the board A, discloses the message Bx on the board A. In addition, when the server (10) refers to the information disclosable range information of each board and determines that the boards capable of disclosing a message of the board A includes the board B, discloses the message Ax on the board B.

Abstract: An estimation device (10) receives a device ID for identifying a device in a network and an observation event that has occurred in the device from a user terminal (20) as an input. The estimation device (10) acquires attribute information of the device corresponding to the received device ID from a device information storage unit (13c), estimates a risk that the device in the network is subject to an attack on the basis of the acquired attribute information and the received observation event, and outputs the estimated attack risk to the user terminal (20).

Abstract: A server (10) stores a task ID of information on a task that is viewed by a client terminal (20) and a screen shot when the client terminal (20) logs out from the server (10) as a user activity log of the client terminal (20). In addition, when the client terminal (20) logs into the server (10) once again, the server (10) refers to the user activity log of the client terminal (20) and displays a screen shot upon a previous logout. Furthermore, the server (10) refers to a task ID included in the user activity log of the client terminal (20) and displays unread tasks of the client terminal (20) .

Abstract: A management device (10) includes a mission pack acquisition unit (12a), a process set acquisition unit (12b), and an integration unit (12c). The mission pack acquisition unit (12a) acquires a mission pack associated with a set of check items to be implemented during crisis response and association between a process indicating a phase of a critical event and the mission pack. The process set acquisition unit (12b) acquires a process set associated with a set of processes. The integration unit (12c) integrates, for each process set, association among the process, the mission pack, and the check items as integrated information (11d).

Abstract: Based on a presentation rule in which a DB to be searched, a search condition, and a user terminal targeted for presentation are set, a support device transmits, to a management device, a know-how search request including a search condition corresponding to a presentation type in a presentation request according to the presentation type indicating which business the presentation of know-how is requested for. The support device integrates returned pieces of know-how information, and presents the integrated know-how information to a user terminal. The management device searches, if the requester is allowed to access the DB to be searched based on control information in which a DB to be disclosed and a type of know-how information are associated with disclosure destination information indicating a destination for disclosure.

Abstract: A management apparatus (20) includes: a storage unit (21) which stores user attribute information that associates a user who manages information related to crises and an attribute of the user with each other, correspondence information that associates the attribute and an external system of which the attribute is login-enabled with each other, and login information with respect to each external system; an external login information processing unit (223) which, when receiving a login request to an external system from a user, refers to the user attribute information, the correspondence information, and the login information stored in the storage unit, acquires an attribute of the user, and acquires information on an external system to which the acquired attribute is login-enabled; and an external login processing unit (224) which executes a login to an external system to which a login has been requested among the login-enabled external systems.

Abstract: A server (10) that manages a plurality of boards refers to, when a similarity between a message Ax of a board A and a message Bx of a board B is equal to or greater than a prescribed value, information disclosable range information of each board, and when it is determined that boards capable of disclosing a message of the board B includes the board A, discloses the message Bx on the board A. In addition, when the server (10) refers to the information disclosable range information of each board and determines that the boards capable of disclosing a message of the board A includes the board B, discloses the message Ax on the board B.

Abstract: An support system server (100) accepts, for each board related to crisis response activity, browsing of one or more messages registered in the board and registration of a message in the board. When a transmission source of a received e-mail is an e-mail address of a user of the board, the support system server (100) registers a message included in the e-mail in the board. When a new message is registered in the board, the support system server (100) distributes an e-mail including the message to the e-mail address of the user of the board.

Abstract: The purpose of the present invention is to provide a novel compound which has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare that are causative bacteria of MAC infection and which is different in backbone structure from known drugs for treatment of MAC infection. One aspect of the present invention relates to a compound of Formula (I) [where R1 has the same meaning as described in the specification and claims] or a salt thereof, or a solvate thereof. Another aspect of the present invention relates to a method for producing the compound of Formula (I) or a salt thereof, or a solvate thereof, and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), which comprises the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient.

Abstract: Disclosed is an agent for improving at least one activity selected from the group consisting of the growth activity, adhesion activity and extension activity of mesenchymal stem cells, which comprises laminin-5 as an active ingredient. A method of culturing mesenchymal stem cells; a method of isolating mesenchymal stem cells; and a medium, vessel or sheet for use in culturing mesenchymal stem cells are also provided.

Abstract: Disclosed is an agent for improving at least one activity selected from the group consisting of the growth activity, adhesion activity and extension activity of mesenchymal stem cells, which comprises laminin-5 as an active ingredient. A method of culturing mesenchymal stem cells; a method of isolating mesenchymal stem cells; and a medium, vessel or sheet for use in culturing mesenchymal stem cells are also provided.

Abstract: A method for the detection of telomerase activity, for the detection of cancer cells and for the diagnosis of cancer comprising amplifying an oligonucleotide sequence extended by a DNA extension reaction with a telomerase and hybridizing the resulting amplified product with a probe labelled with a non-radioactive material to detect the telomerase activity, as well as a diagnositic kit for use in said method for the detection and diagnosis.

Abstract: A method for the detection of telomerase activity, for the detection of cancer cells and for the diagnosis of cancer comprising amplifying an oligonucleotide sequence extended by a DNA extension reaction with a telomerase and hybridizing the resulting amplified product with a probe labelled with a non-radioactive material to detect the telomerase activity, as well as a diagnositic kit for use in said method for the detection and diagnosis.