Patents by Inventor Junli Chen

Junli Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIMIDO-PYRIDAZINONE COMPOUND AS TOLL-LIKE RECEPTOR AGONIST
    Publication number: 20250195524
    Abstract: A compound of formula I, and a preparation method therefor and a use thereof as a TLR7 and/or TLR8 agonist are provided. The compound can be used for preparing a pharmaceutical composition for treating or preventing tumors or infections caused by viruses.
    Type: Application
    Filed: March 20, 2023
    Publication date: June 19, 2025
    Inventors: Guozhi TANG, Dawei MA, Junli CHEN, Yingyi WANG, Yongfu LIU
  • Process for the preparation of tetrahydropyridopyrimidines
    Patent number: 12319686
    Abstract: The present invention relates to a process for synthesizing a compound of formula (I), or a pharmaceutically acceptable salt thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: June 3, 2025
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Junli Chen, Weichun Chen, Lin Wang
  • PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST
    Publication number: 20250059183
    Abstract: A toll-like receptor agonist, and preparation therefor and an application thereof are provided. Specifically, a compound as shown in formula I, a preparation method therefor, and a use thereof as a TLR7 and/or TLR8 agonist are provided. The compound can be used for preparing a pharmaceutical composition for treating or preventing tumors or infection caused by virus.
    Type: Application
    Filed: December 8, 2022
    Publication date: February 20, 2025
    Inventors: Guozhi TANG, Dawei MA, Junli CHEN, Yongfu LIU, Jinliang ZHANG, Riming QUE
  • DIHYDROPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Publication number: 20240166649
    Abstract: Disclosed are a dihydropyrimidine compound, a preparation method therefor and an application thereof. Specifically, disclosed are a dihydropyrimidine compound represented by formula 1? or a pharmaceutically acceptable salt thereof, a composition comprising the compound, and an application of the compound in preparing a drug for treating and preventing hepatitis B virus (HBV) infection related diseases. The disclosed dihydropyrimidine compound can effectively suppress the activity of HBV in HepG2.2.15 cells, and is less toxic to liver cancer cells.
    Type: Application
    Filed: February 8, 2022
    Publication date: May 23, 2024
    Inventors: Guozhi TANG, Dawei MA, Junli CHEN, Mengwei HUANG, Jinliang ZHANG, Guoliang ZHANG
  • PROCESS FOR THE PREPARATION OF TETRAHYDROPYRIDOPYRIMIDINES
    Publication number: 20220098189
    Abstract: The present invention relates to a process for synthesizing a compound of formula (I), or a pharmaceutically acceptable salt thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
    Type: Application
    Filed: January 16, 2020
    Publication date: March 31, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Junli CHEN, Weichun CHEN, Lin WANG
  • Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds
    Patent number: 11142534
    Abstract: The present invention relates to a process for synthesizing a compound of formula (I), R1 is H or C1-6alkyl; R2 is H or hydroxy; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: October 12, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Junli Chen, Manuel Konrath, Roland Meier, Yan Ren, Xuemei Wang, Jing Xiong, Jianhua Yu
  • Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid
    Patent number: 10927116
    Abstract: The present invention relates to a process for synthesizing a compound of formula (I), R1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C1-6alkyl; R2 is C1-6alkyl; R3 is —CxH2x—; x is 1, 2, 3, 4, 5, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: February 23, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Junli Chen
  • PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-d]PYRIMIDINE-2,7-DIONE COMPOUNDS
    Publication number: 20200024287
    Abstract: The present invention relates to a process for synthesizing a compound of formula (I), R1 is H or C1-6alkyl; R2 is H or hydroxy; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
    Type: Application
    Filed: January 4, 2018
    Publication date: January 23, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Junli CHEN, Manuel KONRATH, Roland MEIER, Yan REN, Xuemei WANG, Jing XIONG, Jianhua YU
  • Process for the preparation of N-[(3-aminooxetan-3-yl) methyl]-2-(1,1-dioxo-3,5-dihydro-1,4-benzothiazepin-4-yl)-6-methyl-quinazolin-4-amine
    Patent number: 10253022
    Abstract: The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: April 9, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Junli Chen, Yi Ren, Jin She, Lin Wang, Jianhua Yu, Guocai Zhang
  • Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5.6.8.8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid
    Publication number: 20190010155
    Abstract: The present invention relates to a process for synthesizing a compound of formula (I), R1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C1-6alkyl; R2 is C1-6alkyl; R3 is —CxH2x—; x is 1, 2, 3, 4, 5, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
    Type: Application
    Filed: August 20, 2018
    Publication date: January 10, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventor: Junli Chen
  • PROCESS FOR THE PREPARATION OF N-[(3-AMINOOXETAN-3-YL) METHYL]-2-(1,1-DIOXO-3,5-DIHYDRO-1,4-BENZOTHIAZEPIN-4-YL)-6-METHYL-QUINAZOLIN-4-AMINE
    Publication number: 20180265505
    Abstract: The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.
    Type: Application
    Filed: May 24, 2018
    Publication date: September 20, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: JUNLI CHEN, YI REN, JIN SHE, LIN WANG, JIANHUA YU, GUOCAI ZHANG
  • Spirodiamine derivatives as aldosterone synthase inhibitors
    Patent number: 10035804
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R5, A1, A2, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: July 31, 2018
    Assignee: Hoffman-La Roche Inc.
    Inventors: Johannes Aebi, Kurt E. Amrein, Junli Chen, Benoit Hornsperger, Bernd Kuhn, Yongfu Liu, Dongbo Li, Hans Peter Maerki, Rainer E. Martin, Alexander Mayweg, Xuefei Tan, Jun Wu, Jianhua Yu
  • Process for the preparation of N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-1,4-benzothiazepin-4-yl)-6-methyl-quinazolin-4-amine
    Patent number: 10005770
    Abstract: The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: June 26, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Junli Chen, Yi Ren, Jin She, Lin Wang, Jianhua Yu, Guocai Zhang
  • SPIRODIAMINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS
    Publication number: 20170204107
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R5, A1, A2, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 5, 2017
    Publication date: July 20, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Kurt E. Amrein, Junli Chen, Benoit Hornsperger, Bernd Kuhn, Yongfu Liu, Dongbo Li, Hans Peter Maerki, Rainer E. Martin, Alexander Mayweg, Xuefei Tan, Jun Wu, Jianhua Yu
  • PROCESS FOR THE PREPARATION OF N-[(3-AMINOOXETAN-3-YL)METHYL]-2-(1,1-DIOXO-3,5-DIHYDRO-1,4-BENZOTHIAZEPIN-4-YL)-6-METHYL-QUINAZOLIN-4-AMINE
    Publication number: 20160326160
    Abstract: The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.
    Type: Application
    Filed: July 21, 2016
    Publication date: November 10, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Junli CHEN, Yi REN, Jin SHE, Lin WANG, Jianhua YU, Guocai ZHANG
  • Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine
    Patent number: 9388168
    Abstract: The present invention relates to a novel process for the preparation of of the formula (I) (I) wherein R1 and R2 are described herein. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds for treating diseases or conditions associated with inhibiting actin polymerization.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: July 12, 2016
    Assignee: HUA MEDICINE
    Inventors: Junli Chen, Yi Ren, Jin She, Lin Wang
  • Process for the Preparation of 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine
    Publication number: 20150315176
    Abstract: The present invention relates to a novel process for the preparation of of the formula (I) (I) wherein R1 and R2 are described herein. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds for treating diseases or conditions associated with inhibiting actin polymerization.
    Type: Application
    Filed: December 20, 2013
    Publication date: November 5, 2015
    Inventors: Junli Chen, Yi Ren, Jin She, Lin Wang