Abstract: The present disclosure provides a pharmaceutical composition or drug kit for alleviating or treating fibrotic diseases, and a use thereof. Disclosed is a novel medication regimen in which a platelet endothelial aggregation receptor 1 (PEAR1) agonist and pirfenidone or nintedanib are used in combination.

Abstract: Provided are a product and a method for treating thrombocytopenia. The product and the method can fundamentally solve the problem of thrombocytopenia from the perspective of an autoimmune mechanism.

Abstract: Disclosed is a new method for improving the quality of platelets. It is disclosed for the first time that the molecular of carnitine palmitoyl transferase II (CPT2) of the platelet mitochondrial inner membrane is critical to the survival, preparation and storage of platelets, the reduction of CPT2 protein expression and/or activity seriously affects the quality of platelets, and the normal or high expression of the protein improves the quality of platelets. By means of directly and indirectly influencing or modifying CPT2 protein, the effect of CPT2 on platelets is verified at multiple angles, and a pathway and endogenous or exogenous molecules having a key effect of maintaining activity of platelets are disclosed.

Abstract: The present application discloses a backlight module and a display device. The backlight module includes a light guide plate, and the light-emitting surface includes a plurality of light-emitting units arranged in rows. A backlight plate is arranged on the light guide plate, and a plurality of transparent hole units are arranged on the backlight plate. A shutter layer is arranged on the backlight plate, and a number of shutter units are arranged on the shutter layer. The shutter units are arranged corresponding to the transparent hole units. The shutter units are used to control whether light passing through the transparent hole units passes through the shutter layer.

Abstract: Provided is a drug for preventing, alleviating or treating adhesion and a use thereof. A fibroblast which has been subjected to external stimulation in a body cavity contains an activated negative regulatory receptor PEAR1. The deletion of the fibroblast PEAR1 can significantly promote in vivo mucosal adhesion formation. A PEARI agonist can specifically inhibit fibroblast activation, synthesize an extracellular matrix, and ameliorate the adhesion lesion. By administering the PEARI agonist, the formation of adhesion can be effectively prevented. Also provided is a PEARI agonistic antibody that does not affect the repair and healing of normal tissue and does not cause the tissue to be in an anoxic state. Moreover, the antibody drug has a long half-life, is easily diffused, has few side effects, and has a convenient route of administration.

Abstract: The present invention provides a novel antithrombotic antibody, the antibody uses FIXa as a target and has unique properties, and specifically targets the binding site of coagulation factor FIXa and FVIIIa, reduces the formation of a FVIIa-FIXa complex, blocks the conversion of FX to FXa, and thereby exerts an antithrombotic effect. The antibody of the present invention has suitable antithrombotic properties, and has a large effective therapeutic concentration window, but does not increase the risk of bleeding in addition, the antibody can meet the needs for suitable antithrombotic performance in clinical application and for effective avoidance of problems regarding bleeding caused by excessive effects. The present invention also discloses a method for screening drugs by using an FIXa-FVIIIa binding site as a target.

Abstract: The present application discloses a backlight module and a display device. The backlight module includes a light guide plate, and the light-emitting surface includes a plurality of light-emitting units arranged in rows. A backlight plate is arranged on the light guide plate, and a plurality of transparent hole units are arranged on the backlight plate. A shutter layer is arranged on the backlight plate, and a number of shutter units are arranged on the shutter layer. The shutter units are arranged corresponding to the transparent hole units. The shutter units are used to control whether light passing through the transparent hole units passes through the shutter layer.

Abstract: The present application discloses a display panel and a manufacturing method thereof. The display panel manufacturing method includes forming an LED die including a sacrificial layer on an array substrate, and then coating black glue material on the array substrate. The black glue material covers the array substrate and a surface of the sacrificial layer away from the array substrate. Then, the black glue material and the sacrificial layer are heated, and the black glue material is cured to form a black glue layer such that the sacrificial layer is decomposed. The display panel and the manufacturing method thereof provided by the present application are for improving contrast of the display panel.

Abstract: The present disclosure provides a display device and a manufacturing method thereof. The display device includes: a substrate; a conductive layer disposed on the substrate; and a reflective layer disposed on the conductive layer; wherein a plurality of flask-shaped holes are disposed in the reflective layer and part of the conductive layer, and a depth of each of the flask-shaped holes is greater than a thickness of the reflective layer.

Abstract: Embodiments of the present application disclose a manufacturing method of a display panel and the display panel. By welding a metal film on a side of a back plate through a soldering aid layer, the soldering aid layer is converted into a welding portion, the metal film is electrically connected to a plurality of first wires through the welding portion; bending the metal film to a second surface of the back plate; and patterning the metal film and the welding portion to form a plurality of second wires, the second wires are disposed on the side and the second surface of the back plate, and the second wires are electrically connected to corresponding ones of the first wires.

Abstract: The present application discloses a display panel and a manufacturing method thereof. The display panel manufacturing method includes forming an LED die including a sacrificial layer on an array substrate, and then coating black glue material on the array substrate. The black glue material covers the array substrate and a surface of the sacrificial layer away from the array substrate. Then, the black glue material and the sacrificial layer are heated, and the black glue material is cured to form a black glue layer such that the sacrificial layer is decomposed. The display panel and the manufacturing method thereof provided by the present application are for improving contrast of the display panel.

Abstract: The present application provides an array substrate and a fabrication method thereof, and a display device. By etching a second insulating layer using a patterned black negative-type photoresist layer as an etching barrier layer, a second conductive member for transmitting electrical signals and having a same layer as source/drain electrodes is exposed. The second conductive member replaces an indium tin oxide in conventional technology to electrically connect a driving chip, thereby reducing processes of forming indium tin oxide and use of a photomask, simplifying production process, saving production costs, and improving production efficiency.

Abstract: Disclosed are Pear 1 and, serving as a target of fibrotic diseases, applications in a medicament for treating human Pear 1-related diseases. Also disclosed are a Pear 1-targeting antibody or a mutant of same or a composition comprising same and applications thereof. Disclosed are a humanized Pear 1 transgenic mice model, a construction method for same, and applications thereof. The technical solution of the present invention regulates fibroblast activation and has broad application prospects in treating fibrotic diseases and accompanying debilitating diseases.

Abstract: The present disclosure provides a method for ordering comments, and apparatus, device and computer storage medium thereof, which relates to the technical field of 5 big data. A specific implementation solution is as follows: obtaining comments data, ordering the comments based on basic attributes of the comment to obtain a first ordering result, and establishing an index for the first ordering result; in response to obtaining an event of the user triggering display of the comments, obtaining the first ordering result through the index, and performing ordering adjustment on the first 10 ordering result based on the user's feature data to obtain a second ordering result which serves as a basis for displaying the comments to the user. The present disclosure can meet the user's personalized needs for comment ordering.

Abstract: The present disclosure provides a display device and a manufacturing method thereof. The display device includes: a substrate; a conductive layer disposed on the substrate; and a reflective layer disposed on the conductive layer; wherein a plurality of flask-shaped holes are disposed in the reflective layer and part of the conductive layer, and a depth of each of the flask-shaped holes is greater than a thickness of the reflective layer.

Abstract: An array substrate, a manufacturing method thereof, and a display panel are provided. The array substrate is divided into a display area and a bending area and includes a glass substrate and a flexible substrate. Wherein, the glass substrate is disposed corresponding to the display area, and the flexible substrate is disposed corresponding to the bending area. A plurality of bonding wirings in the bending area are respectively connected to a plurality of signal lines in the display area. The flexible substrate is bent to a back surface of the array substrate to perform chip on film (COF) bonding, thereby preventing a lower yield problem caused by using nano silver glues.

Abstract: A manufacturing method of a backlight module is provided, which includes forming a first conductive layer and a first insulating layer on a substrate, forming an active material layer on the first conductive layer, patterning the first insulating layer and the active material layer by using a multi-tone photomask to expose a portion of the first conductive layer and cause the active material layer to form an active member, and forming a third conductive layer on the active member to form a source and drain of the backlight module.

Abstract: The present invention provides a backplate manufacturing method including: manufacturing a second metal layer on an underlay substrate; patterning the second metal layer to form an anode and a cathode; forming a first passivation layer on the second metal layer, patterning the first passivation layer to form an aperture region, wherein the aperture region is configured to expose out the anode and the cathode; manufacturing a second passivation layer on the first passivation layer, the anode, and the cathode; manufacturing a light shielding layer on the second passivation layer, patterning the light shielding layer to remove a part of the light shielding layer in a position corresponding to the aperture region; and removing a part of the second passivation layer above the anode and the cathode. The method of the present invention can provide a soldering effect of the light emitting device and a yield rate of a backplate.

Abstract: An array substrate, a manufacturing method thereof, and a display device are provided. The array substrate includes a substrate; an array layer, wherein the array layer includes a conductive pad and a conductive electrode disposed on the substrate; and a scratch prevention layer disposed on a side of the array layer away from the substrate, wherein the scratch prevention layer includes a first hollowed region and a second hollowed region, the first hollowed region corresponds to the conductive pad, and the second hollowed region corresponds to the conductive electrode.