Abstract: Synthetic nucleic acids encoding mini and microdystrophin genes comprising the membrane binding motifs or domains of the R10-R11-R12 region are provided. Also provided are vectors, host cells, and related methods of using the same to treat a subject suffering from Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) or X-linked dilated cardiomyopathy (XLDC), or for ameliorating one or more adverse effects of DMD, BMD, or XLDC. Also provided are a fusion protein comprising a nNOS binding domain of dystrophin R16-R17 that is operably linked to a syntrophin PDZ domain and synthetic nucleic acids comprising the same that can be used to treat subjects with diseases characterized by loss of sarcolemmal neuronal nitric oxide synthase (nNOS) activity.

Abstract: A synergist for a water-base drilling fluid and a preparation method therefor, a water-base drilling fluid and an application thereof, and belongs to the field of drilling fluid technologies. The synergist is prepared from raw materials comprising the following parts by weight: 15˜25 parts of sodium styrene sulfonate, 8˜15 parts of allyl trimethyl ammonium chloride, 2˜8 parts of didodecyldimethylammonium bromide, 1˜5 parts of n-octyl triethoxysilane, 1˜5 parts of propyltriethoxysilane, 1˜5 parts of disodium lauryl sulfosuccinate, 10˜20 parts of nano silica, 8˜15 parts of paraffin, and the like.

Abstract: A tire sensor attachment structure is provided. The tire includes a pair of bead areas, a sidewall extending from each respective bead area to a tread, a carcass extending toroidally between each of the bead areas, and an innerliner that is disposed radially inwardly of the carcass. A sensor housing is attached to the innerliner, and defines an interior chamber. A sensor is disposed in the chamber. The tire sensor attachment structure includes a compressible body that is disposed in the chamber between the sensor and the innerliner.

Abstract: Synthetic nucleic acids encoding mini and microdystrophin genes comprising the membrane binding motifs or domains of the R10-R11-R12 region are provided. Also provided are vectors, host cells, and related methods of using the same to treat a subject suffering from Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) or X-linked dilated cardiomyopathy (XLDC), or for ameliorating one or more adverse effects of DMD, BMD, or XLDC. Also provided are a fusion protein comprising a nNOS binding domain of dystrophin R16-R17 that is operably linked to a syntrophin PDZ domain and synthetic nucleic acids comprising the same that can be used to treat subjects with diseases characterized by loss of sarcolemmal neuronal nitric oxide synthase (nNOS) activity.

Abstract: The invention relates to preparation of a rubber composition which contains polybutadiene elastomers with balanced reinforcing filler network, rubber composition prepared thereby and tire with at least one component comprised of such rubber composition.

Abstract: The present disclosure provides a synergist for a water-base drilling fluid and a preparation method therefor, a water-base drilling fluid and an application thereof, and belongs to the field of drilling fluid technologies. The synergist is prepared from raw materials comprising the following parts by weight: 15˜25 parts of sodium styrene sulfonate, 8˜15 parts of allyl trimethyl ammonium chloride, 2˜8 parts of didodecyldimethylammonium bromide, 1˜5 parts of n-octyl triethoxysilane, 1˜5 parts of propyltriethoxysilane, 1˜5 parts of disodium lauryl sulfosuccinate, 10˜20 parts of nano silica, 8˜15 parts of paraffin, and the like.

Abstract: The present disclosure provides a video recommendation method and a video recommendation apparatus, a computer device and a storage medium. The video recommendation method includes: acquiring a target short video; identifying, from candidate long videos, a target long video that the target short video is from based on a video fingerprint feature of the target short video and video fingerprint features of the candidate long videos; and recommending the target long video.

Abstract: The invention relates to preparation of a rubber composition which contains polybutadiene elastomers with balanced reinforcing filler network, rubber composition prepared thereby and tire with at least one component comprised of such rubber composition.

Abstract: According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal nNOS is provided. The biological material comprises the complete dystrophin repeats R16 and R17 or certain domains, sections, or fragments of the dystrophin repeats R16 and R17. In some aspects, such domains, sections, or fragments may be selected from sequence motifs including dystrophin R17 ?1 helix, ?2 and ?3 helices of both R16 and R17, or a combination thereof.

Abstract: Synthetic nucleic acids encoding mini and microdystrophin genes comprising the membrane binding motifs or domains of the R10-R11-R12 region are provided. Also provided are vectors, host cells, and related methods of using the same to treat a subject suffering from Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) or X-linked dilated cardiomyopathy (XLDC), or for ameliorating one or more adverse effects of DMD, BMD, or XLDC. Also provided are a fusion protein comprising a nNOS binding domain of dystrophin R16-R17 that is operably linked to a syntrophin PDZ domain and synthetic nucleic acids comprising the same that can be used to treat subjects with diseases characterized by loss of sarcolemmal neuronal nitric oxide synthase (nNOS) activity.

Abstract: Pneumatic rubber tire intended for heavy duty service having a tread containing a combination of functionalized cis 1,4-polybutadiene rubber and reinforcing filler containing precipitated silica.

Abstract: The invention relates to a tire having a rubber tread of a circumferentially zoned tread. The tread zones are comprised of three circumferential load bearing zones, with each zone containing a portion of the running surface of the tread, comprised of an intermedial rubber zone positioned between and extending beneath two stratified lateral tread rubber zones. The tread configuration contains an underlying carbon black-rich base rubber layer. The lateral tread rubber zones are therefore spaced apart from each other with the intermedial tread zone therebetween and also spaced apart from the tread base rubber layer with the intermedial tread zone therebetween. The intermedial and stratified lateral zones are comprised of rubber compositions having differentiated rebound physical properties.

Abstract: The invention relates to a phased rubber composition and tire tread thereof intended for heavy duty service such as for example a truck tire. The phased rubber composition is comprised of the product of blending a first rubber phase comprised of cis 1,4-polybutadiene rubber and reinforcing filler comprised of rubber reinforcing carbon black and a second rubber phase comprised of natural cis 1,4-polyisoprene rubber and reinforcing filler comprised of precipitated silica.

Abstract: According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal nNOS is provided. The biological material comprises the complete dystrophin repeats R16 and R17 or certain domains, sections, or fragments of the dystrophin repeats R16 and R17. In some aspects, such domains, sections, or fragments may be selected from sequence motifs including dystrophin R17 ?1 helix, ?2 and ?3 helices of both R16 and R17, or a combination thereof.

Abstract: The invention relates to a tire having a rubber tread of a circumferentially zoned tread. The tread zones are comprised of three circumferential load bearing zones, with each zone containing a portion of the running surface of the tread, comprised of a silica-rich intermedial rubber zone positioned between and extending beneath two carbon black-rich lateral tread zones. The tread configuration contains an underlying carbon black-rich base rubber layer. The intermedial and stratified lateral zones are comprised of rubber compositions having differentiated rebound physical properties. A path of least electrical resistance extends from a lateral carbon black-rich rubber tread zone to the carbon black-rich tread base layer by an extension of a lateral tread zone or by an intermediate carbon black-rich rubber bridge.

Abstract: The invention relates to pneumatic tires having treads of a cap/base configuration where the outer tread cap rubber layer contains lugs with intervening grooves which extend to the running surface of the tread cap and wherein at least one of said grooves is contained in a rubber block within the tread. For this invention, the tread groove-containing rubber block joins the tire carcass and extends radially outward through the tread base rubber layer and into the outer tread cap rubber layer.

Abstract: Pneumatic rubber tire intended for heavy duty service having a tread containing a combination of functionalized cis 1,4-polybutadiene rubber and reinforcing filler containing precipitated silica.

Abstract: According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal nNOS is provided. The biological material comprises the complete dystrophin repeats R16 and R17 or certain domains, sections, or fragments of the dystrophin repeats R16 and R17. In some aspects, such domains, sections, or fragments may be selected from sequence motifs including dystrophin R17 ?1 helix, ?2 and ?3 helices of both R16 and R17, or a combination thereof.

Abstract: The invention relates to a phased rubber composition and tire tread thereof intended for heavy duty service such as for example a truck tire. The phased rubber composition is comprised of the product of blending a first rubber phase comprised of cis 1,4-polybutadiene rubber and reinforcing filler comprised of rubber reinforcing carbon black and a second rubber phase comprised of natural cis 1,4-polyisoprene rubber and reinforcing filler comprised of precipitated silica.