Patents by Inventor Junning Lee

Junning Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydrochloride salts of a glycopeptide-cephalosporin antbiotic compond
    Patent number: 9161990
    Abstract: The present invention relates to a compound of formula I: wherein x is in the range of from about 1 to about 2. The invention also relates to pharmaceutical compositions containing such compounds; processes for preparing such compounds; and methods of using such compounds to, for example, treat a bacterial infection.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: October 20, 2015
    Assignee: Theravance Biopharma Antibiotics IP, LLC
    Inventors: Weijiang Zhang, Ronnie Cheung, Dimitar Filipov, Jack Green, Junning Lee
  • Crystalline form of a substituted thiazolylacetic acid triethylamine salt
    Patent number: 9139542
    Abstract: The invention relates to a crystalline form of a triethylamine salt of (2Z)-2-(2 -amino-5-chlorothiazol-4-yl)-2-(3-N-tert-butoxycarbonylaminopropoxyimino)acetic acid. The invention also relates to processes and intermediates for preparing the crystalline form. The crystalline form is useful as an intermediate for preparing cross-linked glycopeptide-cephalosporin antibiotics.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: September 22, 2015
    Assignee: THERAVANCE BIOPHARMA ANTIBIOTICS IP, LLC
    Inventors: Weijiang Zhang, Michael R. Tracey, Junning Lee
  • HYDROCHLORIDE SALTS OF AN ANTIBIOTIC COMPOUND
    Publication number: 20140274877
    Abstract: The present invention relates to a compound of formula I: wherein x is in the range of from about 1 to about 2. The invention also relates to pharmaceutical compositions containing such compounds; processes for preparing such compounds; and methods of using such compounds to, for example, treat a bacterial infection.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 18, 2014
    Applicant: THERAVANCE, INC.
    Inventors: Weijiang Zhang, Ronnie Cheung, Dimitar Filipov, Jack Green, Junning Lee
  • CRYSTALLINE FORM OF A SUBSTITUTED THIAZOLYLACETIC ACID TRIETHYLAMINE SALT
    Publication number: 20140275554
    Abstract: The invention relates to a crystalline form of a triethylamine salt of (2Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(3-N-tert-butoxycarbonylaminopropoxyimino)acetic acid. The invention also relates to processes and intermediates for preparing the crystalline form. The crystalline form is useful as an intermediate for preparing cross-linked glycopeptide-cephalosporin antibiotics.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 18, 2014
    Applicant: THERAVANCE, INC.
    Inventors: Weijiang Zhang, Michael R. Tracey, Junning Lee
  • Process for preparing glycopeptide phosphonate derivatives
    Patent number: 8093354
    Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: January 10, 2012
    Assignee: Theravance, Inc.
    Inventors: Michael R. Leadbetter, Martin S. Linsell, Junning Lee, Jyanwei Liu
  • Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds
    Patent number: 8030502
    Abstract: This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: October 4, 2011
    Assignee: Theravance, Inc.
    Inventors: Mathai Mammen, David Oare, Junning Lee, Weijiang Zhang
  • Hydrochloride salts of a glycopeptide phosphonate derivative
    Patent number: 8003755
    Abstract: Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.
    Type: Grant
    Filed: April 8, 2008
    Date of Patent: August 23, 2011
    Assignee: Thervance, Inc.
    Inventors: Jyanwei Liu, Junning Lee
  • PROCESS FOR PREPARING GLYCOPEPTIDE PHOSPHONATE DERIVATIVES
    Publication number: 20110060122
    Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
    Type: Application
    Filed: April 13, 2010
    Publication date: March 10, 2011
    Applicant: THERAVANCE, INC.
    Inventors: Michael R. Leadbetter, Martin S. Linsell, Junning Lee, Jyanwei Liu
  • Process for preparing glycopeptide phosphonate derivatives
    Patent number: 7728104
    Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: June 1, 2010
    Assignee: Theravance, Inc.
    Inventors: Michael R. Leadbetter, Martin S. Linsell, Junning Lee, Jyanwei Liu
  • Process for preparing intermediates to 5-HT receptor agonist compounds
    Patent number: 7671198
    Abstract: The invention provides 8-azabicyclo[3.2.1 ]octyl intermediates useful for the preparation of 5-HT4 receptor agonist compounds. The invention also provides processes for the preparation of such useful intermediates.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: March 2, 2010
    Assignee: Theravance, Inc.
    Inventors: Daniel Genov, Junning Lee, Jyanwei Liu
  • Process for preparing substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds
    Patent number: 7572918
    Abstract: Processes and intermediates for preparing substituted 4-amino-1-(pyridylmethyl)-piperidine and related compounds in high yield and high purity are described. The substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds prepared by the described processes are useful as muscarinic receptor antagonists.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: August 11, 2009
    Assignee: Theravance, Inc.
    Inventors: Matthew J Peterson, Junning Lee, Richard J Lee, Weijiang Zhang
  • Hydrochloride salts of a glycopeptide phosphonate derivative
    Patent number: 7531623
    Abstract: Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: May 12, 2009
    Assignee: Theravance, Inc.
    Inventors: Jyanwei Liu, Junning Lee
  • Hydrochloride salts of a glycopeptide phosphonate derivative
    Publication number: 20090069534
    Abstract: Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.
    Type: Application
    Filed: April 8, 2008
    Publication date: March 12, 2009
    Inventors: Jyanwei Liu, Junning Lee
  • Process for preparing glycopeptide phosphonate derivatives
    Publication number: 20080227963
    Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
    Type: Application
    Filed: October 24, 2007
    Publication date: September 18, 2008
    Inventors: Michael R. Leadbetter, Martin S. Linsell, Junning Lee, Jyanwei Liu
  • Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds
    Publication number: 20080091034
    Abstract: This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.
    Type: Application
    Filed: October 17, 2007
    Publication date: April 17, 2008
    Inventors: Mathai Mammen, David Oare, Junning Lee, Weijiang Zhang
  • Crystalline form of a biphenyl compound
    Patent number: 7320990
    Abstract: The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro-quinolin-5 -yl)ethylamino]nonyl}piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: January 22, 2008
    Assignee: Theravance, Inc.
    Inventors: Robert Chao, Miroslav Rapta, Pierre-Jean Colson, Junning Lee
  • Process for preparing glycopeptide phosphonate derivatives
    Patent number: 7301004
    Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: November 27, 2007
    Assignee: Theravance, Inc.
    Inventors: Michael R. Leadbetter, Martin S. Linsell, Junning Lee, Jyanwei Liu
  • Process for preparing intermediates to 5-HT4 receptor agonist compounds
    Publication number: 20070191355
    Abstract: The invention provides 8-azabicyclo[3.2.1 ]octyl intermediates useful for the preparation of 5-HT4 receptor agonist compounds. The invention also provides processes for the preparation of such useful intermediates.
    Type: Application
    Filed: February 15, 2007
    Publication date: August 16, 2007
    Inventors: Daniel Genov, Junning Lee, Jyanwei Liu
  • Process for preparing glycopeptide derivatives
    Patent number: 7160984
    Abstract: Disclosed are processes for preparing glycopeptide antibiotic derivatives having an amino-containing side chain. The multi-step process is conducted in a single reaction vessel without isolation of intermediate reaction products.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: January 9, 2007
    Assignee: Theravance, Inc.
    Inventors: Junning Lee, Jyanwei Liu
  • Process for preparing glycopeptide phosphonate derivatives
    Publication number: 20060264607
    Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
    Type: Application
    Filed: May 19, 2006
    Publication date: November 23, 2006
    Inventors: Michael Leadbetter, Martin Linsell, Junning Lee, Jyanwei Liu