Abstract: The field is related to plant breeding and methods of identifying and selecting plants with resistance to southern corn rust. Provided are methods to identify novel genes that encode proteins providing plant resistance to southern corn rust and uses thereof. These disease resistant genes are useful in the production of resistant plants through breeding, transgenic modification, or genome editing.

Abstract: A method for transmitting a signal, and an apparatus, a storage medium, and a user terminal are provided. The method includes: determining a plurality of baseband signals of Component Carriers (CC); selecting a plurality of phase rotation factors and recording a number of times of selection by adding one each time of selection; determining a candidate signal and a Peak to Average Power Ratio (PAPR) of the candidate signal, wherein in response to the PAPR being greater than or equal to a preset threshold and the number of times of selections not reaching a preset number of times, reselecting phase rotation factors and re-determining another candidate signal and a PAPR of the another candidate signal, until a PAPR is less than the preset threshold or the number of times of selections reaches the preset number of times; and transmitting the candidate signal.

Abstract: Provided are a cell strain HEK293.CS for reducing the production of a replication competent adenovirus, and a construction method and the use thereof. HEK293.CS is a safe adenovirus-producing cell line constructed by knocking out a gene fragment homologous to the Ad5 adenovirus E1 gene in HEK293 and providing a template plasmid to replace said gene fragment with a non-homologous sequence that stabilizes the expression of the E1 gene. Compared with the unmodified HEK293 cell strain, HEK293.CS shows no decrease in growth ability and virus production ability, but does not produce a detectable RCA. HEK293.CS can be used for the mass culture of a recombinant human type 5 adenovirus, and reducing the probability of RCA production in the manufacture process of drugs such as vaccines and antibodies.

Abstract: Provided are a method and apparatus for determining a delay compensation value, a device, and a computer-readable storage medium. The method includes: obtaining a channel frequency domain impulse response of a transmit link, where the transmit link is obtained by combining at least two hardware modules in a transmit circuit, obtaining a time domain impulse response according to the channel frequency domain impulse response, and determining a delay compensation value of the transmit link according to a preset condition and the time domain impulse response.

Abstract: Provided are an mRNA or an mRNA composition, and an mRNA vaccine comprising the mRNA or the mRNA composition. The mRNA or the mRNA composition comprises an mRNA sequence encoding an S protein of a novel coronavirus SARS-CoV-2 or a variant thereof, and an mRNA sequence encoding an RBD in the S protein or a variant thereof. Further provided are the applications of the mRNA or the mRNA composition, and the mRNA vaccine comprising the mRNA or the mRNA composition in preparation of a medication for preventing and/or treating a disease caused by a novel coronavirus SARS-CoV-2 infection.

Abstract: Provided is a method for preparing an adenovirus vector vaccine by means of a perfusion culture process. The method comprises a step of culturing adenovirus host cells, and in particular a step of adjusting the perfusion rate by means of at least two stages according to cell density. The method increases the single cell yield of a virus after infection and the specific activity of a virus harvest liquid while achieving high-density growth of adenovirus host cells.

Abstract: Provided are a networking signal sending method and device for a positioning network. The method includes: determining a networking mode of the positioning network according to an application scene, wherein the networking mode includes independent networking of the positioning network and joint networking of the positioning network and a communication network; and configuring a positioning base station of the positioning network, or the positioning base station and a communication base station according to the networking mode, wherein the positioning base station is used for sending a positioning signal or the positioning signal and a synchronization signal, and the communication base station is used for sending the synchronization signal.

Abstract: Provided are a protein antigen subjected to site-directed mutation and site-directed modification, and a method for site-directed mutation and site-directed modification of the protein antigen. The method comprises: site-directedly introducing an unnatural amino acid into a specific site of the protein antigen by genetic codon expansion technique; and performing site-directed modification with the protein antigen by the unnatural amino acid and a modifier, wherein the modifier is a receptor agonist such as tripalmitoyl-S-glyceryl cysteine and monophosphoryl lipid A. Further provided is use of the protein antigen subjected to site-directed mutation and site-directed modification, such as use as a vaccine.

Abstract: Disclosed is a SARS-CoV-2 vaccine, wherein the S protein of SARS-CoV-2 serves as the antigen, and the vaccine comprises an adenoviral vector, and the vaccine induces an improved protective immune response through mucosal immunity, thus preventing SARS-CoV-2 infection. Specifically, when atomized by an appropriate apparatus, the vaccine generates particles of improved uniformity, which can reach the lungs after being inhaled via the nasal cavity or the oral cavity, thus producing a protective immune response with respect to the entire respiratory tract and the lungs, enhancing the effective utilization rate of the vaccine, and increasing the effect of the vaccine.

Abstract: Disclosed are a cooperative positioning method and apparatus, a device, and a non-transitory computer-readable storage medium. The method may include: determining an initial positioning estimated value of each of a plurality of objects to be measured by a simulated annealing algorithm and a first preset positioning algorithm; screening at least two distance measurement values based on a preset error threshold to obtain a target distance measurement value, where the at least two distance measurement values are measurement values obtained by measuring a distance between each object to be measured and each of a plurality of target base stations for at least two times; and determining a position of each object to be measured according to a multi-target-source Taylor series algorithm, each target distance measurement value and each initial positioning estimated value.

Abstract: Disclosed are a method and an apparatus for determining time of arrival, a signal receiving device, and a non-transitory computer readable storage medium. The method for determining time of arrival includes: generating time of arrival correction information according to front edge information of theoretical autocorrelation waveforms of positioning signals having different fading values; calculating a front edge slope corresponding to a front edge reference point of a correlation waveform of an actually received signal; and determining target correction information from the time of arrival correction information according to the front edge slope, and determining the time of arrival of the actually received signal based on the target correction information.

Abstract: A method and device for determining a time of arrival (TOA), a terminal device, and a non-transitory computer-readable storage medium are disclosed. The method may include: determining a detection start time on a correlation waveform based on a leading edge detection threshold; determining a noise threshold on the correlation waveform, and determining a quasi-TOA according to the detection start time; and determining the TOA according to data information in a target area of the correlation waveform and the noise threshold, where the target area is determined based on the quasi-TOA and a detection length.

Abstract: A method for transmitting a signal, and an apparatus, a storage medium, and a user terminal are provided. The method includes: determining a plurality of baseband signals of Component Carriers (CC); selecting a plurality of phase rotation factors and recording a number of times of selection by adding one each time of selection; determining a candidate signal and a Peak to Average Power Ratio (PAPR) of the candidate signal, wherein in response to the PAPR being greater than or equal to a preset threshold and the number of times of selections not reaching a preset number of times, reselecting phase rotation factors and re-determining another candidate signal and a PAPR of the another candidate signal, until a PAPR is less than the preset threshold or the number of times of selections reaches the preset number of times; and transmitting the candidate sign.

Abstract: Disclosed is an SamRNA vaccine, including a recombinant viral vector which includes: i) a viral gene replication complex including nucleotide sequences encoding viral gene replication-related proteins nsP1, nsP2, nsP3, and nsP4; and ii) a nucleotide sequence encoding at least one antigen. According to the SamRNA vaccine of the present invention, in addition to that a promoter of a modified adenoviral vector itself can transcribe an antigen gene to form mRNA, the viral gene replication-related proteins nsP1-4 use RNA as a template to synthesize a large amount of mRNAs, and the immune effect of a target antigen is greatly improved.

Abstract: An emissive perovskite ternary composite thin film comprising a perovskite material, an ionic-conducting polymer and an ionic-insulating polymer is provided. Additionally, a single-layer LEDs is described using a composite thin film of organometal halide perovskite (Pero), an ionic-conducting polymer (ICP) and an ionic-insulating polymer (IIP). The LEDs with Pero-ICP-IIP composite thin films exhibit a low turn-on voltage of about 1.9V (defined at 1 cd m?2 luminance) and a luminance of about 600,000 cd m?2.