Patents by Inventor Junqing Ye

Junqing Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for reprograming non-pluripotent cells into pluripotent stem cells
    Patent number: 12180509
    Abstract: Provided are chemical inducers of pluripotency (CIP) which include glycogen synthase kinase inhibitors, TGF? receptor inhibitors, cyclic AMP agonists and S-adenosylhomocysteine hydrolase (SAH) inhibitors or histone acetylators. A method of inducing pluripotency in a partially or completely differentiated cell by using such chemical inducers of pluripotency is also provided. The method includes: (i) contacting a cell with the CIPs for a sufficient period of time to result in reprograming the cell into a pluripotent stem cell having ESC-like characteristics (CiPSC). Isolated chemically induced pluripotent stem cells (CiPSCs) and their progeny, produced by inducing differentiation of the CiPSCs, can be used in a number of applications, including but not limited to cell therapy and tissue engineering.
    Type: Grant
    Filed: July 22, 2021
    Date of Patent: December 31, 2024
    Assignees: BeiHao Stem Cell and Regenerative Medicine Research Institute Co., Ltd., Hong Guan Ltd.
    Inventors: Hongkui Deng, Yang Zhao, Ting Zhao, Jingyang Guan, Xu Zhang, Yao Fu, Junqing Ye
  • METHODS FOR REPROGRAMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS
    Publication number: 20220025321
    Abstract: Provided are chemical inducers of pluripotency (CIP) which include glycogen synthase kinase inhibitors, TGF? receptor inhibitors, cyclic AMP agonists and S-adenosylhomocysteine hydrolase (SAH) inhibitors or histone acetylators. A method of inducing pluripotency in a partially or completely differentiated cell by using such chemical inducers of pluripotency is also provided. The method includes: (i) contacting a cell with the CIPs for a sufficient period of time to result in reprograming the cell into a pluripotent stem cell having ESC-like characteristics (CiPSC). Isolated chemically induced pluripotent stem cells (CiPSCs) and their progeny, produced by inducing differentiation of the CiPSCs, can be used in a number of applications, including but not limited to cell therapy and tissue engineering.
    Type: Application
    Filed: July 22, 2021
    Publication date: January 27, 2022
    Inventors: Hongkui Deng, Yang Zhao, Ting Zhao, Jingyang Guan, Xu Zhang, Yao Fu, Junqing Ye
  • IMPROVED METHODS FOR REPROGRAMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS
    Publication number: 20190282624
    Abstract: Provided are chemical inducers of pluripotency (CIP) which include glycogen synthase kinase inhibitors, TGF? receptor inhibitors, cyclic AMP agonists and S-adenosylhomocysteine hydrolase (SAH) inhibitors or histone acetylators. A method of inducing pluripotency in a partially or completely differentiated cell by using such chemical inducers of pluripotency is also provided. The method includes: (i) contacting a cell with the CIPs for a sufficient period of time to result in reprogramming the cell into a pluripotent stem cell having ESC-like characteristics (CiPSC). Isolated chemically induced pluripotent stem cells (CiPSCs) and their progeny, produced by inducing differentiation of the CiPSCs, can be used in a number of applications, including but not limited to cell therapy and tissue engineering.
    Type: Application
    Filed: November 30, 2015
    Publication date: September 19, 2019
    Inventors: Hongkui Deng, Yang Zhao, Ting Zhao, Jingyang Guan, Xu Zhang, Yao Fu, Junqing Ye