Patents by Inventor Junshan RUAN

Junshan RUAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10066052
    Abstract: A docetaxel nano-polymer micelle lyophilized preparation is disclosed including methoxypolyethylene glycol-polylactic acid block copolymer carrier material and docetaxel, the docetaxel being is encapsulated in the carrier material. A mass ratio of the docetaxel to the carrier material is 0.01-0.15. The methoxypolyethylene glycol-polylactic acid block copolymer is formed by ring opening polymerization of D,L-lactide and methoxypolyethylene glycol. A mass ratio of the methoxypolyethylene glycol to the D,L-lactide is 1:0.55-0.65 or 1:0.73-0.89 or 1:0.91-0.99. The mass ratio of the docetaxel to the carrier is further optimized by adjusting a mass ratio of polyester to polyether in the methoxypolyethylene glycol polylactide block copolymer. The encapsulation efficiency of a docetaxel micelle prepared by the block copolymer after being re-dissolved by water can be greater than 90% at 12 hours.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: September 4, 2018
    Assignee: Suzhou High-Tech Biosciense Co., Ltd.
    Inventors: Junshan Ruan, Pengfei Du, Limian Wang, Huan Zhou
  • Patent number: 9683073
    Abstract: A methoxypolyethylene glycol-polylactic acid block copolymer is disclosed, the methoxypolyethylene glycol-polylactic acid block copolymer being a block copolymer formed by ring opening polymerization of D,L-lactide and methoxypolyethylene glycol. A mass ratio of the methoxypolyethylene glycol to the D,L-lactide is 1:0.55-0.65 or 1:0.73-0.89 or 1:0.91-0.99. A preparation method of the foregoing block copolymer is also provided. When the block copolymer is used as a carrier for preparing a drug micelle, the encapsulation efficiency of the drug micelle prepared after being re-dissolved by water can be greater than 90% at 12 hours.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: June 20, 2017
    Assignee: Suzhou High-Tech Bioscience Co., Ltd
    Inventors: Junshan Ruan, Pengfei Du, Limian Wang, Huan Zhou
  • Publication number: 20160137775
    Abstract: A methoxypolyethylene glycol-polylactic acid block copolymer is disclosed, the methoxypolyethylene glycol-polylactic acid block copolymer being a block copolymer formed by ring opening polymerization of D,L-lactide and methoxypolyethylene glycol. A mass ratio of the methoxypolyethylene glycol to the D,L-lactide is 1:0.55-0.65 or 1:0.73-0.89 or 1:0.91-0.99. A preparation method of the foregoing block copolymer is also provided. When the block copolymer is used as a carrier for preparing a drug micelle, the encapsulation efficiency of the drug micelle prepared after being re-dissolved by water can be greater than 90% at 12 hours.
    Type: Application
    Filed: July 16, 2014
    Publication date: May 19, 2016
    Applicant: Suzhou High-Tech Bioscience Co., Ltd.
    Inventors: Junshan Ruan, Pengfei Du, Limian Wang, Huan Zhou
  • Publication number: 20160128940
    Abstract: A docetaxel nano-polymer micelle lyophilized preparation is disclosed including methoxypolyethylene glycol-polylactic acid block copolymer carrier material and docetaxel, the docetaxel being is encapsulated in the carrier material. A mass ratio of the docetaxel to the carrier material is 0.01-0.15. The methoxypolyethylene glycol-polylactic acid block copolymer is formed by ring opening polymerization of D,L-lactide and methoxypolyethylene glycol. A mass ratio of the methoxypolyethylene glycol to the D,L-lactide is 1:0.55-0.65 or 1:0.73-0.89 or 1:0.91-0.99. The mass ratio of the docetaxel to the carrier is further optimized by adjusting a mass ratio of polyester to polyether in the methoxypolyethylene glycol polylactide block copolymer. The encapsulation efficiency of a docetaxel micelle prepared by the block copolymer after being re-dissolved by water can be greater than 90% at 12 hours.
    Type: Application
    Filed: July 16, 2014
    Publication date: May 12, 2016
    Inventors: Junshan RUAN, Pengfei DU, Limian WANG, Huan ZHOU