Abstract: Disclosed is a mutant of a wild-type RSV F protein. The binding experiment of a pre-fusion conformation trimer-specific monoclonal antibody AM14 shows that the mutant provided in embodiments can have strong activity of binding to the AM14 monoclonal antibody, while the wild-type RSV F protein before artificial mutation has no activity of binding to the AM14 monoclonal antibody. The accelerated stability test result shows that the activity of binding of the mutant provided in the embodiments when placed in a 37° C. environment for four weeks to the AM14 monoclonal antibody does not change obviously. The animal immune experiment result shows that compared with the wild-type RSV F protein before artificial mutation, the mutant provided in the embodiments can induce production of a neutralizing antibody having a higher titer.

Abstract: The present invention discloses an S-RBD trimer protein for a novel coronavirus. The trimer protein is composed of amino acid fragments at positions 319-537 in an RBD domain of an S protein of the novel coronavirus n a trimer form. A body is immunized with a vaccine prepared in the present invention taking the S-RBD trimer protein as an antigen and supplemented by an adjuvant, and then a hic neutralizing antibody for the novel coronavirus may be produced and may be used for treating and/or preventing novel coronavirus (SARS-CoV-2) infection and/or a novel coronavirus disease.

Abstract: The present invention provides a recombinant RBD trimer protein capable of simultaneously generating cross neutralization activity for various severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) epidemic strains. The RBD trimer protein is taken as an antigen and supplemented with an adjuvant to immunize an organism, so that a high-titer neutralizing antibody aiming at various SARS-COV-2 epidemic strains can be generated at the same time, and the antibody has a certain broad-spectrum property and can be used for treating and/or preventing SARS-COV-2 infection and/or coronavirus disease 2019.

Abstract: The present invention discloses a recombinant RBD trimer protein capable of simultaneously generating cross neutralization activity for various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic strains. The RBD trimer protein is taken as an antigen and supplemented with an adjuvant to immunize an organism, so that a high-titer neutralizing antibody aiming at various SARS-CoV-2 epidemic strains can be generated at the same time, and the antibody has a certain broad-spectrum property and can be used for treating and/or preventing SARS-CoV-2 infection and/or coronavirus disease 2019.

Abstract: The present disclosure belongs to the technical field of electrocatalytic materials, and provides a graphitic carbon-doped and mixed crystal-type titanium dioxide nanotube composite for electrocatalysis, and a preparation method and use thereof. The composite for electrocatalysis includes a titanium substrate and a titanium dioxide nanomesh deposited on the titanium substrate, where the titanium dioxide nanomesh is woven from titanium dioxide nanowires; the titanium dioxide nanowires include anatase-type titanium dioxide nanowires and rutile-type titanium dioxide nanowires. The mixed crystal-type titanium dioxide phase improves a catalytic activity of the composite for electrocatalysis; meanwhile, the titanium dioxide nanowires are further loaded with graphitic carbon particles to improve an overall conductivity of the composite for electrocatalysis.

Abstract: The present disclosure belongs to the technical field of electrocatalytic materials, and provides a graphitic carbon-doped and mixed crystal-type titanium dioxide nanotube composite for electrocatalysis, and a preparation method and use thereof. The composite for electrocatalysis includes a titanium substrate and a titanium dioxide nanomesh deposited on the titanium substrate, where the titanium dioxide nanomesh is woven from titanium dioxide nanowires; the titanium dioxide nanowires include anatase-type titanium dioxide nanowires and rutile-type titanium dioxide nanowires. The mixed crystal-type titanium dioxide phase improves a catalytic activity of the composite for electrocatalysis; meanwhile, the titanium dioxide nanowires are further loaded with graphitic carbon particles to improve an overall conductivity of the composite for electrocatalysis.

Abstract: The present application provides an address translation method and system for a KV storage device. The provided address translation method for a read operation for a KV storage device includes: obtaining a logical address accessed by a read operation; and if the logical address hits a cached translation page, obtaining a physical address corresponding to the logical address from the cached translation page.

Abstract: The present application provides a KV storage device and a method of using a KV storage device to provide a file system. The provided method for a KV storage device includes: receiving a logical key for accessing a KV storage device; acquiring a physical key corresponding to the logical key; and querying an address translation table to obtain an address corresponding to the physical key, wherein a value corresponding to the logical key is stored in the address.

Abstract: The present application provides an address translation method and system for a KV storage device. The provided address translation method for a read operation for a KV storage device includes: obtaining a logical address accessed by a read operation; and if the logical address hits a cached translation page, obtaining a physical address corresponding to the logical address from the cached translation page.

Abstract: The present disclosure relates to a computer-implemented method for simulating an analog and mixed-signal circuit design having a digital circuit segment connected to an analog circuit segment at a connection point. The method may include inserting a bidirectional interface element at the connection point located between the digital circuit segment and the analog circuit segment. The method may further include splitting the digital circuit segment into a plurality of transistor network models to provide for bidirectional transfer of data between the analog circuit segment and the digital circuit segment.

Abstract: According to some embodiments, a method is provided for simulating an analog and mixed-signal circuit design comprising an analog circuit segment connected to a digital circuit segment at a connection point, the method comprising: inserting a bi-directional interface element at the connection point, wherein the analog circuit segment connects to an analog port of the bi-directional interface element and the digital circuit segment connects to a digital port of the bi-directional interface element; and operating the bi-directional interface element such that the bi-directional interface element detects a signal direction and, according to the signal direction, either converts a first analog signal received from the analog port to a first digital signal for the digital port while maintaining a first signal strength of the first analog signal, or converts a second digital signal received from the digital port to a second analog signal for the analog port while maintaining a second signal strength of the second d

Abstract: A method of simulating an analog mixed-signal circuit design using mixed-language descriptions includes initializing a mixed language simulation cycle, processing digital events during delta cycles at a current simulation time of the cycle, and, after the digital events are processed, determining an analog solution at the current simulation time.