Patents by Inventor Junwei Li
Junwei Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12287419Abstract: The invention discloses an UWB NLOS signal recognition method based on the first path of CIR, including constructing a UWB ranging system comprising tags and anchors. The system controls communication between the anchor and tag, processes the raw CIR data obtained from each communication to construct data samples, and labels these samples to build a raw CIR dataset. Peak filtering is then performed on the CIR waveforms in the raw CIR dataset to identify the first path peak points of the data samples. Based on the first path peak points, valid data is determined as new data samples, and one-hot encoding is applied to the data labels. A training dataset is constructed using all new data samples and their corresponding data labels. A machine learning model is then developed and trained using the training dataset, and the trained model is saved for identifying unknown CIR signals.Type: GrantFiled: June 25, 2024Date of Patent: April 29, 2025Assignee: Guangdong University of TechnologyInventors: Qianqian Cai, Haoqiang Ou, Junwei Li, Xiaopei Chen, Wentao Zhong
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Publication number: 20250116749Abstract: The invention discloses an UWB NLOS signal recognition method based on the first path of CIR, including constructing a UWB ranging system comprising tags and anchors. The system controls communication between the anchor and tag, processes the raw CIR data obtained from each communication to construct data samples, and labels these samples to build a raw CIR dataset. Peak filtering is then performed on the CIR waveforms in the raw CIR dataset to identify the first path peak points of the data samples. Based on the first path peak points, valid data is determined as new data samples, and one-hot encoding is applied to the data labels. A training dataset is constructed using all new data samples and their corresponding data labels. A machine learning model is then developed and trained using the training dataset, and the trained model is saved for identifying unknown CIR signals.Type: ApplicationFiled: June 25, 2024Publication date: April 10, 2025Applicant: Guangdong University of TechnologyInventors: Qianqian CAI, Haoqiang OU, Junwei LI, Xiaopei CHEN, Wentao ZHONG
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Patent number: 12268617Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.Type: GrantFiled: February 19, 2024Date of Patent: April 8, 2025Assignee: Covidien LPInventors: Xiaodong Ma, Min-Shyan Sheu, Lincoln Eramo, John Wainwright, Junwei Li
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Patent number: 12256936Abstract: Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity and deforming a shape of the occlusive member via introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall.Type: GrantFiled: May 25, 2023Date of Patent: March 25, 2025Assignee: COVIDIEN LPInventors: Junwei Li, John Wainwright, Gaurav Girdhar, Stephen Sosnowski
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Patent number: 12251110Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible conduit having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the conduit distal portion. The conduit has a lumen configured to pass an embolic element therethrough.Type: GrantFiled: October 5, 2022Date of Patent: March 18, 2025Assignee: COVIDIEN LPInventors: Hoai Nguyen, Junwei Li, Andyanhdzung Huynh
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Publication number: 20250032121Abstract: Treatment of aneurysms can be improved by delivering an occlusive implant (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an expandable member that releasably engages the occlusive implant to an engagement portion of a conduit. When the expandable member is collapsed, the conduit is disengaged from a proximal hub of the occlusive implant. The conduit and expandable member may then be retracted while the occlusive implant remains at the treatment site.Type: ApplicationFiled: July 25, 2024Publication date: January 30, 2025Inventors: Mehdi M. Rashidi, Robert A. Pecor, Junwei Li, Nelson M. Siu, Belinko K. Matsuura, David G. Matsuura
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Publication number: 20240390010Abstract: Devices, systems, and methods for treating aneurysms are disclosed herein. According to some embodiments, the present technology includes a treatment system comprising a delivery shaft, a manipulation shaft slidably positioned within the lumen of the delivery shaft, and an occlusive device configured for implantation within the aneurysm. The occlusive device can comprise a plurality of filaments that are secured to one another at a proximal end of the occlusive device by a cured material. The occlusive device can comprise inner and outer layers of braided filaments, wherein the proximal end region of the inner layer has an exposed portion that extends proximally beyond the proximal end region of the outer layer, and wherein the cured material extends into and fills interstices between the braided filaments at the proximal end regions of the inner and outer layers.Type: ApplicationFiled: July 31, 2024Publication date: November 28, 2024Inventors: Mehdi Matteo Rashidi, Junwei Li, Belinko K. Matsuura, David G. Matsuura, Nelson M. Siu
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Patent number: 12138034Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).Type: GrantFiled: December 15, 2023Date of Patent: November 12, 2024Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., The General Hospital CorporationInventors: Robert S. Langer, Carlo Giovanni Traverso, Malvika Verma, Feyisope Eweje, Christoph Winfried Johannes Steiger, Junwei Li, Nhi Phan, Hen-Wei Huang, Jacqueline Chu, John Ashraf Fou Salama
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Publication number: 20240366719Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.Type: ApplicationFiled: May 10, 2024Publication date: November 7, 2024Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Carlo Giovanni Traverso, Junwei Li, Thomas Wang, Ameya R. Kirtane, Yunhua Shi
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Publication number: 20240341769Abstract: Occlusion devices are disclosed herein. According to some embodiments, the present technology includes a mesh configured to be positioned within an aneurysm cavity, the mesh having a low-profile configuration for delivery through a catheter to the aneurysm cavity and an expanded configuration for implantation in the aneurysm cavity. The mesh can comprise a first portion configured to be positioned over the aneurysm neck and a second portion configured to be positioned between the first portion and a dome of the aneurysm. The mesh can comprise a copper material at the second portion of the mesh, wherein the copper material is configured to promote thrombosis within the aneurysm cavity.Type: ApplicationFiled: April 10, 2024Publication date: October 17, 2024Inventors: Zhijun Bai, Junwei Li
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Patent number: 12070221Abstract: Devices, systems, and methods for treating aneurysms are disclosed herein. According to some embodiments, the present technology includes a treatment system comprising a delivery shaft, a manipulation shaft slidably positioned within the lumen of the delivery shaft, and an occlusive device configured for implantation within the aneurysm. The occlusive device can comprise a plurality of filaments that are secured to one another at a proximal end of the occlusive device by a cured material. The occlusive device can comprise inner and outer layers of braided filaments, wherein the proximal end region of the inner layer has an exposed portion that extends proximally beyond the proximal end region of the outer layer, and wherein the cured material extends into and fills interstices between the braided filaments at the proximal end regions of the inner and outer layers.Type: GrantFiled: July 30, 2022Date of Patent: August 27, 2024Assignee: COVIDIEN LPInventors: Mehdi Matteo Rashidi, Junwei Li, Belinko K. Matsuura, David G. Matsuura, Nelson M. Siu
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Patent number: 12060825Abstract: A two-stage turbocharging energy-efficient self-adaptive control method based on multi-point intake and exhaust pressures in diesel engine turbocharging field, including: determining a target turbocharging pressure for plains upon diesel engine speed and load conditions; adjusting it to obtain optimal target turbocharging pressures for varying altitudes; using these and measured multi-point pressures in intake and exhaust pipelines as inputs, based on an energy utilization analysis model, to determine the two-stage turbocharging energy utilization efficiency suitable for different altitude environmental conditions; according to the optimal overall efficiency principle of the two-stage turbocharging system at variable altitudes, calculating opening degrees of the bypass valves that meets the target total pressure ratio by a valve control unit. Reasonable distribution of exhaust energy between the two-stage turbochargers is achieved.Type: GrantFiled: March 4, 2024Date of Patent: August 13, 2024Assignee: Shanhai Jiao Tong UniversityInventors: Lei Shi, Ling Leng, Junwei Li, Yong Zhang, Kangyao Deng
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Publication number: 20240216469Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide a broad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.Type: ApplicationFiled: March 5, 2024Publication date: July 4, 2024Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Carlo Giovanni Traverso, Ameya R. Kirtane, Junwei Li, Thomas Wang, James Byrne, Alexis Jones
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Intelligent variable mode control method for variable altitude turbocharging system of diesel engine
Patent number: 12025066Abstract: An intelligent variable mode control method for variable altitude turbocharging system of diesel engine, including: querying turbocharging pressure MAP chart upon speed and torque demands; reading a target pressure, and correcting it to obtain a corrected pressure; based on adaptive ranges of flow-pressure ratio of turbocharging modes, using fuzzy control algorithms to achieve intelligent selection of turbocharging modes; initializing opening degrees of high- and low-pressure stage bypass valves within adjustment ranges; using neural network fast prediction models to predict turbocharging pressures; using genetic algorithms to fast search bypass valve opening degrees corresponding the target and send them to the valve control unit.Type: GrantFiled: March 4, 2024Date of Patent: July 2, 2024Assignee: Shanhai Jiao Tong UniversityInventors: Lei Shi, Ling Leng, Ziqiang Chen, Junwei Li, Kangyao Deng -
Patent number: 12016901Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.Type: GrantFiled: December 10, 2020Date of Patent: June 25, 2024Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Carlo Giovanni Traverso, Junwei Li, Thomas Wang, Ameya R. Kirtane, Yunhua Shi
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Publication number: 20240189121Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.Type: ApplicationFiled: February 19, 2024Publication date: June 13, 2024Inventors: Xiaodong Ma, Min-Shyan Sheu, Lincoln Eramo, John Wainwright, Junwei Li
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Publication number: 20240182907Abstract: The present invention relates to innovative protoparvoviruses (PV) expressing RNAi effectors, preferably shRNAs against the PD-L1 gene which display improved anticancer activity. These new viruses are based on the ?H-1PVsilencer platform that consists of a protoparvovirus H-1PV featuring an in-frame deletion within the NS region (?H-1PV) and harbouring a shRNA expression cassette in which the expression of the shRNA is controlled by the H1 Polymerase III promoter. In this invention the inventors aimed to use the ?H-1PVsilencer to silence the PD-L1 gene. PD1/PD-L1 negatively regulates T cell-mediated immune responses and serves as a mechanism for tumors to escape antigen-specific T cell immune responses. The present invention also provides cells or organisms comprising said parvovirus.Type: ApplicationFiled: April 13, 2022Publication date: June 6, 2024Inventors: Junwei Li, Barbara Leuchs, Michael W. Dahm, Ying Chen
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Publication number: 20240108241Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).Type: ApplicationFiled: December 15, 2023Publication date: April 4, 2024Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., The General Hospital CorporationInventors: Robert S. Langer, Carlo Giovanni Traverso, Malvika Verma, Feyisope Eweje, Christoph Winfried Johannes Steiger, Junwei Li, Nhi Phan, Hen-Wei Huang, Jacqueline Chu, John Ashraf Fou Salama
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Publication number: 20240075565Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the core wire distal portion. A conduit extends along at least a portion of the core wire. The conduit has a lumen configured to pass an embolic element therethrough.Type: ApplicationFiled: November 9, 2023Publication date: March 7, 2024Inventors: Junwei Li, Mark Ashby, Hoai Nguyen
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Patent number: D1032336Type: GrantFiled: April 27, 2022Date of Patent: June 25, 2024Inventor: Junwei Li