Abstract: Occlusive devices and associated methods of manufacturing are disclosed herein. Manufacturing an occlusive device can include conforming a mesh to a forming assembly and setting a shape of the mesh based on the forming assembly. In some embodiments, the forming assembly comprises multiple forming members, a mandrel, and/or one or more coupling elements. The method may include everting the mesh over the forming assembly such that the mesh encloses an open volume with a shape based, at least in part, on the shape of the forming assembly. According to some embodiments, setting a shape of the mesh comprises heat-treating the mesh and forming assembly.

Abstract: A method for treating an aneurysm in accordance with a particular embodiment of the present technology includes intravascularly delivering a mixture including a biopolymer (e.g., chitosan) and a chemical crosslinking agent (e.g., genipin) to an aneurysm. The method further includes mixing the biopolymer and the chemical crosslinking agent to initiate chemical crosslinking of the biopolymer. The mixture is delivered to the aneurysm via a lumen and an exit port of a catheter while the chemical crosslinking is ongoing. The mixture exits the catheter as a single cohesive strand that at least partially agglomerates to form a mass occupying at least 75% of a total internal volume of the aneurysm. During delivery of the mixture, the method includes expanding a tubular flow diverter to reinforce a neck of the aneurysm.

Abstract: Injectable biopolymer compositions and associated systems and methods are disclosed herein. In some embodiments, a biopolymer composition for treating an aneurysm is provided. The biopolymer composition can include an injectable hydrogel including: a biopolymer; a chemical crosslinker forming covalent bonds with the biopolymer; and a stabilizer configured to inhibit ex vivo precipitation of the biopolymer. The injectable hydrogel can have an ex vivo storage modulus of at least 100 Pa at 37° C. over a linear viscoelastic region of the injectable hydrogel. The ex vivo storage modulus can be greater than an ex vivo loss modulus of the injectable hydrogel over the linear viscoelastic region of the injectable hydrogel.

Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible conduit having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the conduit distal portion. The conduit has a lumen configured to pass an embolic element therethrough.

Abstract: Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity and deforming a shape of the occlusive member via introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall.

Abstract: Occlusive devices and associated methods of manufacturing are disclosed herein. Manufacturing an occlusive device can include conforming a mesh to a forming assembly and setting a shape of the mesh based on the forming assembly. In some embodiments, the forming assembly comprises multiple forming members, a mandrel, and/or one or more coupling elements. The method may include everting the mesh over the forming assembly such that the mesh encloses an open volume with a shape based, at least in part, on the shape of the forming assembly. According to some embodiments, setting a shape of the mesh comprises heat-treating the mesh and forming assembly.

Abstract: The invention discloses an UWB NLOS signal recognition method based on the first path of CIR, including constructing a UWB ranging system comprising tags and anchors. The system controls communication between the anchor and tag, processes the raw CIR data obtained from each communication to construct data samples, and labels these samples to build a raw CIR dataset. Peak filtering is then performed on the CIR waveforms in the raw CIR dataset to identify the first path peak points of the data samples. Based on the first path peak points, valid data is determined as new data samples, and one-hot encoding is applied to the data labels. A training dataset is constructed using all new data samples and their corresponding data labels. A machine learning model is then developed and trained using the training dataset, and the trained model is saved for identifying unknown CIR signals.

Abstract: The invention discloses an UWB NLOS signal recognition method based on the first path of CIR, including constructing a UWB ranging system comprising tags and anchors. The system controls communication between the anchor and tag, processes the raw CIR data obtained from each communication to construct data samples, and labels these samples to build a raw CIR dataset. Peak filtering is then performed on the CIR waveforms in the raw CIR dataset to identify the first path peak points of the data samples. Based on the first path peak points, valid data is determined as new data samples, and one-hot encoding is applied to the data labels. A training dataset is constructed using all new data samples and their corresponding data labels. A machine learning model is then developed and trained using the training dataset, and the trained model is saved for identifying unknown CIR signals.

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

Abstract: Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity and deforming a shape of the occlusive member via introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall.

Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible conduit having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the conduit distal portion. The conduit has a lumen configured to pass an embolic element therethrough.

Abstract: Treatment of aneurysms can be improved by delivering an occlusive implant (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an expandable member that releasably engages the occlusive implant to an engagement portion of a conduit. When the expandable member is collapsed, the conduit is disengaged from a proximal hub of the occlusive implant. The conduit and expandable member may then be retracted while the occlusive implant remains at the treatment site.

Abstract: Devices, systems, and methods for treating aneurysms are disclosed herein. According to some embodiments, the present technology includes a treatment system comprising a delivery shaft, a manipulation shaft slidably positioned within the lumen of the delivery shaft, and an occlusive device configured for implantation within the aneurysm. The occlusive device can comprise a plurality of filaments that are secured to one another at a proximal end of the occlusive device by a cured material. The occlusive device can comprise inner and outer layers of braided filaments, wherein the proximal end region of the inner layer has an exposed portion that extends proximally beyond the proximal end region of the outer layer, and wherein the cured material extends into and fills interstices between the braided filaments at the proximal end regions of the inner and outer layers.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

Abstract: Occlusion devices are disclosed herein. According to some embodiments, the present technology includes a mesh configured to be positioned within an aneurysm cavity, the mesh having a low-profile configuration for delivery through a catheter to the aneurysm cavity and an expanded configuration for implantation in the aneurysm cavity. The mesh can comprise a first portion configured to be positioned over the aneurysm neck and a second portion configured to be positioned between the first portion and a dome of the aneurysm. The mesh can comprise a copper material at the second portion of the mesh, wherein the copper material is configured to promote thrombosis within the aneurysm cavity.

Abstract: Devices, systems, and methods for treating aneurysms are disclosed herein. According to some embodiments, the present technology includes a treatment system comprising a delivery shaft, a manipulation shaft slidably positioned within the lumen of the delivery shaft, and an occlusive device configured for implantation within the aneurysm. The occlusive device can comprise a plurality of filaments that are secured to one another at a proximal end of the occlusive device by a cured material. The occlusive device can comprise inner and outer layers of braided filaments, wherein the proximal end region of the inner layer has an exposed portion that extends proximally beyond the proximal end region of the outer layer, and wherein the cured material extends into and fills interstices between the braided filaments at the proximal end regions of the inner and outer layers.

Abstract: A two-stage turbocharging energy-efficient self-adaptive control method based on multi-point intake and exhaust pressures in diesel engine turbocharging field, including: determining a target turbocharging pressure for plains upon diesel engine speed and load conditions; adjusting it to obtain optimal target turbocharging pressures for varying altitudes; using these and measured multi-point pressures in intake and exhaust pipelines as inputs, based on an energy utilization analysis model, to determine the two-stage turbocharging energy utilization efficiency suitable for different altitude environmental conditions; according to the optimal overall efficiency principle of the two-stage turbocharging system at variable altitudes, calculating opening degrees of the bypass valves that meets the target total pressure ratio by a valve control unit. Reasonable distribution of exhaust energy between the two-stage turbochargers is achieved.

Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide a broad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

Abstract: An intelligent variable mode control method for variable altitude turbocharging system of diesel engine, including: querying turbocharging pressure MAP chart upon speed and torque demands; reading a target pressure, and correcting it to obtain a corrected pressure; based on adaptive ranges of flow-pressure ratio of turbocharging modes, using fuzzy control algorithms to achieve intelligent selection of turbocharging modes; initializing opening degrees of high- and low-pressure stage bypass valves within adjustment ranges; using neural network fast prediction models to predict turbocharging pressures; using genetic algorithms to fast search bypass valve opening degrees corresponding the target and send them to the valve control unit.