Abstract: The present invention belongs to the field of medicine and specifically relates to the use of Selonsertib in the preparation of drugs for the treatment of cancer. The Selonsertib is the English name of the compound 5-(4-cyclopropyl-1H-imidazole-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridine-2-yl)-4-methylbenzamide, and its chemical formula is C24H24FN7O, CAS No.: 1448428-04-3. The results of the present invention show that Selonsertib can efficiently inhibit the activity of RSK4 kinase, and has a significant inhibitory effect on the growth of a variety of tumors, and can reduce the resistance of tumors to EGFR-TKI-targeted drugs when combined with EGFR-TKI-targeted drugs. Selonsertib in combination with Anti-PD1 has a significant effect on inhibiting tumor growth compared with the drug alone. The pharmaceutical composition containing Selonsertib provided by the present invention has a good application prospect in the targeted therapy of a variety of cancers.

Abstract: The disclosure concerns oil drilling technology, and specifically an all-metal intelligent control motor (AMIM). The AMIM comprises an electric control module, a power module and a transmission module. The electric control module determines the axial position of the connecting rod valve through an electromagnet and controls the connection between the connecting rod valve and the piston through an electric motor. The hydraulic pressure of drilling fluid and the spring reaction force in the power module push a double worm to move axially and circumferentially under the action of internal teeth on the inner surface of shell. A one-way bearing ensures that the power module only transmits unidirectional motion. The transmission module axially limits the power module through TC bearings and transmits circumferential motion, drilling pressure and torque to the lower drilling tool. The AMIM is suitable for all kinds of deep well exploration, with a stronger drilling force, a lower cost and a higher applicability.

Abstract: The disclosure concerns oil drilling technology, and specifically an all-metal intelligent control motor (AMIM). The AMIM comprises an electric control module, a power module and a transmission module. The electric control module determines the axial position of the connecting rod valve through an electromagnet and controls the connection between the connecting rod valve and the piston through an electric motor. The hydraulic pressure of drilling fluid and the spring reaction force in the power module push a double worm to move axially and circumferentially under the action of internal teeth on the inner surface of shell. A one-way bearing ensures that the power module only transmits unidirectional motion. The transmission module axially limits the power module through TC bearings and transmits circumferential motion, drilling pressure and torque to the lower drilling tool. The AMIM is suitable for all kinds of deep well exploration, with a stronger drilling force, a lower cost and a higher applicability.

Abstract: An oil and gas fracturing tool is disclosed, mainly involving a fracking tool with an electromagnetic intelligent control sliding sleeve including an outer sleeve section, a dart body section and a control section. The outer sleeve section is at the target location to be fractured. The effect of fracturing is mainly achieved by the dart body, which has an activated state and an inactive state. The initial state is inactive, and the front locking tip can be deformed under pressure during displacement. The diameter can change to pass through any sliding sleeve. When the dart body is counted and is about to reach the fracturing position, the front locking tip is blocked from deformation and cannot be reduced in diameter, thus pressurizing to control the fracturing effect. The control part includes a sensor module, a drive module, a main control module and a power supply module.