Patents by Inventor Junye Xu

Junye Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LOV-D ACYLTRANSFERASE MEDIATED ACYLATION
    Publication number: 20150259718
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Application
    Filed: May 11, 2015
    Publication date: September 17, 2015
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • VARIANT LOVD POLYPEPTIDES AND THEIR USES
    Publication number: 20150240276
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
    Type: Application
    Filed: May 13, 2015
    Publication date: August 27, 2015
    Inventors: Lynne Gilson, Steven J. Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert J. Wilson, Junye Xu
  • Lov-D acyltransferase mediated acylation
    Patent number: 9057085
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: June 16, 2015
    Assignee: Codexis, Inc.
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • VARIANT LOVD POLYPEPTIDES AND THEIR USES
    Publication number: 20150037851
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
    Type: Application
    Filed: August 21, 2014
    Publication date: February 5, 2015
    Inventors: Lynne Gilson, Steven J. Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert J. Wilson, Junye Xu
  • Variant LOVD polypeptides and their uses
    Patent number: 8846362
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: September 30, 2014
    Assignee: Codexis, Inc.
    Inventors: Lynne Gilson, Steven James Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert John Wilson, Junye Xu
  • BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF ARMODAFINIL
    Publication number: 20130260426
    Abstract: The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (?)-2-[(R)-(diphenyl-methyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
    Type: Application
    Filed: December 7, 2011
    Publication date: October 3, 2013
    Inventors: Ee Lui Ang, Oscar Alvizo, Behnaz Behrouzian, Michael Clay, Steven Collier, Ellen Eberhard, Fan Jaslyn Fu, Shiwei Song, Derek Smith, Magnus Widegren, Robert Wilson, Junye Xu, Jun Zhu
  • Variant LovD polypeptides and their uses
    Patent number: 8383382
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: February 26, 2013
    Assignee: Codexis, Inc.
    Inventors: Lynne Gilson, Steven James Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert John Wilson, Junye Xu
  • LOV-D ACYLTRANSFERASE MEDIATED ACYLATION
    Publication number: 20120244582
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Application
    Filed: September 24, 2010
    Publication date: September 27, 2012
    Applicant: CODEXIS, INC.
    Inventors: Steven James Collier, Ee Ling Teo, Joly Sukumaran, Robert John Wilson, Junye Xu
  • VARIANT LOVD POLYPEPTIDES AND THEIR USES
    Publication number: 20110111468
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
    Type: Application
    Filed: September 24, 2010
    Publication date: May 12, 2011
    Applicant: Codexis, Inc.
    Inventors: Lynne GILSON, Steven James COLLIER, Joly SUKUMARAN, Wan Lin YEO, Oscar ALVIZO, Ee Ling TEO, Robert John WILSON, Junye XU