Abstract: Certain aspects of the disclosure provide a method that includes obtaining one or more hybrid modeling frameworks based on a model, each hybrid modeling framework comprising one or more hybrid models; performing triage to select a hybrid modeling framework of the one or more hybrid modeling frameworks that is applicable to the system of interest based on associated metrics and the input data; training each respective hybrid model of the one or more hybrid models of the hybrid modeling framework based on the input data to obtain one or more trained hybrid models configured to model behavior of the system of interest; and determining a rank order of the one or more trained hybrid models based on a benchmark set of data associated with the system of interest.

Abstract: This disclosure relates to methods for determining sodium concentration in biological samples. More particularly, this disclosure relates to methods capable of determining Na+ concentration using nucleic acid complexes.

Abstract: The present invention discloses a quinone compound and pharmaceutical use thereof. The quinone compound has a chemical structure of a general formula (I). The quinone compound has a phamaceutical value and a unique analgesic effect, inhibits inflammation and inhibits invasion and growth of tumor cells. The quinone compound can be used for preparing analgesic drugs, anti-tumor drugs, anti-inflammatory drugs, drugs for treating autoimmune diseases and the like.