Patents by Inventor Junying Yuan

Junying Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of cellular necrosis
    Patent number: 8143300
    Abstract: The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: March 27, 2012
    Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Gregory D. Cuny, Prakash Jagtap, Junying Yuan, Alexei Degterev
  • Inhibitors of cellular necrosis
    Publication number: 20110144169
    Abstract: The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.
    Type: Application
    Filed: March 18, 2008
    Publication date: June 16, 2011
    Inventors: Gregory D. Cuny, Prakash Jagtap, Junying Yuan, Alexei Degterev
  • HETEROCYCLIC INHIBITORS OF NECROPTOSIS
    Publication number: 20100317701
    Abstract: The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-?) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-? induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.
    Type: Application
    Filed: August 20, 2010
    Publication date: December 16, 2010
    Inventors: Gregory D. Cuny, Xin Teng, Junying Yuan, Alexei Degterev, John A. Porco, JR.
  • Autophagy Inducing Compounds and Uses Thereof in Treating Autophagy Associated Diseases
    Publication number: 20100267704
    Abstract: This invention pertains to a class of autophagy inducing compounds that treat diseases caused by misfolded protein aggregates and a screening method for identifying these compounds.
    Type: Application
    Filed: October 10, 2008
    Publication date: October 21, 2010
    Applicants: President an Fellows of Harvard Colege, Shangha Institute of Organic Chemistry Chineesse Academy of Sciences
    Inventors: Junying Yuan, Dawei Ma, Lihong Zhang
  • Compounds, Screens, and Methods of Treatment
    Publication number: 20100190836
    Abstract: The present invention features compounds, pharmaceutical compositions, and methods for treating trauma, ischemia, stroke, degenerative diseases associated with cellular necrosis, and other conditions. Screening assays for identifying compounds useful for treating these conditions are also described.
    Type: Application
    Filed: December 20, 2006
    Publication date: July 29, 2010
    Inventors: Junying Yuan, Alexei Degterev, Junichi Hitomi, Gregory D. Cuny, Prakash Jagtap
  • COMPOUNDS, SCREENS, AND METHODS OF TREATMENT
    Publication number: 20100087453
    Abstract: The present invention features compounds of Formula (I), pharmaceutical compositions, methods of synthesis, and methods for treating diseases and conditions associated with cellular necrosis. Screening assays for identifying compounds useful for treating these conditions are also described.
    Type: Application
    Filed: October 9, 2007
    Publication date: April 8, 2010
    Applicants: President and Fellows of Harvard College, Shanghai Institute of Organic Chemistry
    Inventors: Junying Yuan, Chengye Yuan, Alexei Degterev
  • Heterocyclic inhibitors of necroptosis
    Publication number: 20090099242
    Abstract: The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-?) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-? induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.
    Type: Application
    Filed: August 15, 2008
    Publication date: April 16, 2009
    Inventors: Gregory D. Cuny, Xin Teng, Junying Yuan, Alexei Degterev, John A. Porco, JR.
  • Inhibitors of cellular necrosis
    Patent number: 7491743
    Abstract: The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.
    Type: Grant
    Filed: August 30, 2004
    Date of Patent: February 17, 2009
    Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Gregory D. Cuny, Junying Yuan, Prakash Jagtap, Alexei Degterev
  • Small molecules used to increase cell death
    Patent number: 7390836
    Abstract: The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: June 24, 2008
    Assignee: President and Fellows of Harvard College
    Inventors: Junying Yuan, Alexei Degterev, Timothy J. Mitchison
  • Small molecules used to increase cell death
    Publication number: 20070219277
    Abstract: The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death.
    Type: Application
    Filed: November 30, 2006
    Publication date: September 20, 2007
    Inventors: Junying Yuan, Alexei Degterev, Timothy Mitchison
  • Small molecule inhibitors of necrosis
    Patent number: 7253201
    Abstract: The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: August 7, 2007
    Assignee: President and Fellows of Harvard College
    Inventors: Junying Yuan, Alexei Degterev, Timothy J. Mitchison
  • Small molecules used to increase cell death
    Patent number: 7144905
    Abstract: The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: December 5, 2006
    Assignee: President and Fellows of Harvard College
    Inventors: Junying Yuan, Alexei Degterev, Timothy J. Mitchison
  • Cloning sequencing and characterization of two cell death genes and uses therefor
    Patent number: 7138510
    Abstract: Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally related cell death genes from various organisms; methods and agents for altering (increasing or decreasing) the activity of the cell death-genes and, thus, of altering cell death; and uses therefor. Specifically, two genes shown to be essential for almost all of the cell deaths which occur in the development of C. elegans, referred to as ced-3 and ced-4, have been cloned, sequenced and characterized.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: November 21, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: H. Robert Horvitz, Junying Yuan, Shai Shaham
  • Cloning sequencing and characterization of two cell death genes and uses therefor
    Patent number: 7071302
    Abstract: Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally related cell death genes from various organisms; methods and agents for altering (increasing or decreasing) the activity of the cell death-genes and, thus, of altering cell death; and uses therefor. Specifically, two genes shown to be essential for almost all of the cell deaths which occur in the development of C. elegans, referred to as ced-3 and ced-4, have been cloned, sequenced and characterized.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: July 4, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: H. Robert Horvitz, Junying Yuan, Shai Shaham
  • Altered human interleukin-1? convertase (ICE), NEDD-2, and C. elegans ced-3 polypeptides and uses therefor
    Patent number: 6939850
    Abstract: Described herein is the discovery that human interleukin-1? convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3 protein may be a cysteine protease like ICE and that ICE may be a human equivalent of the nematode cell death gene. Another mammalian protein, the murine NEDD-2 protein, was also found to be similar to Ced-3. The NEDD-2 gene is implicated in the development of the murine central nervous system. On the basis of these findings, novel drugs for enhancing or inhibiting the activity of ICE, ced-3, or related genes are provided. Such drugs may be useful for treating inflammatory diseases and/or diseases characterized by cell deaths, as well as cancers, autoimmune disorders, infections, and hair growth and hair loss. Furthermore, such drugs may be useful for controlling pests, parasites and genetically engineered organisms.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: September 6, 2005
    Assignee: Massachusetts Institute of Technology
    Inventors: H. Robert Horvitz, Junying Yuan, Shai Shaham
  • Small molecule inhibitors of necrosis
    Publication number: 20050131044
    Abstract: The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.
    Type: Application
    Filed: June 29, 2004
    Publication date: June 16, 2005
    Inventors: Junying Yuan, Alexei Degterev, Timothy Mitchison
  • Inhibitors of cellular necrosis
    Publication number: 20050119260
    Abstract: The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.
    Type: Application
    Filed: August 30, 2004
    Publication date: June 2, 2005
    Applicants: Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
    Inventors: Gregory Cuny, Junying Yuan, Prakash Jagtap, Alexei Degterev
  • Small molecules used to increase cell death
    Publication number: 20040266846
    Abstract: The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death.
    Type: Application
    Filed: March 16, 2004
    Publication date: December 30, 2004
    Inventors: Junying Yuan, Alexei Degterev, Timothy J. Mitchison
  • Small molecule inhibitors of necrosis
    Patent number: 6756394
    Abstract: The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: June 29, 2004
    Assignee: President and Fellow of Harvard College
    Inventors: Junying Yuan, Alexei Degterev, Timothy J. Mitchison
  • Small molecules used to increase cell death
    Patent number: 6706766
    Abstract: The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: March 16, 2004
    Assignee: President and Fellows of Harvard College
    Inventors: Junying Yuan, Alexei Degterev, Timothy J. Mitchison