Abstract: An operation control method and system for a clothing treatment device having a drum and a motor is provided. Load inertia of the drum and a fluctuation parameter of the motor are obtained. Load eccentric mass of the clothing treatment device is obtained based on the load inertia, the fluctuation parameter, and predetermined relationship data that is obtained based on pre-stored load inertia, torque fluctuation and load eccentric mass. The fluctuation parameter can be a torque fluctuation parameter or a rotation speed fluctuation parameter. The clothing treatment device can be controlled according to the load eccentric mass to optimize washing operations. For example, clothing and/or inlet water amount can be timely adjusted according to the calculated load eccentric mass. Thus, the clothing treatment device is prevented from producing significant noise during operations, and the service life of the clothing treatment device can be prolonged.