Abstract: Disclosed is a 5-methylchromone and the preparation method and application thereof, the 5-methylchromone has the following structure: wherein R1 and R2 are alkyl groups. The substituted chromone has the biological activity of inhibiting tyrosinase. The preparation method uses 3,5-dihydroxytoluene as a raw material, and synthesis of chromones substituted with different groups at 2-C through acylation, esterification, rearrangement and cyclization reactions, etc. The 5-methylchromone is a completely new compound in condition that R1 is —CH2CH2CH3, and R2 is —CH2CH3, or that R1 is —C(CH3)3, and R2 is H. All the compounds have obvious inhibitory activity against tyrosinase, and can be used to prepare tyrosinase inhibitors or whitening agents.

Abstract: The present disclosure provides a method, an apparatus, a computer device and a storage medium of request processing, where the method comprises: obtaining an application usage request; forwarding, by using a traffic scheduler, the application usage request to a scalable service cluster; the scalable service cluster being used to run a created instance matching various application usage requests; and in response to receiving a non-idle state indication fed back by the scalable service cluster, forwarding, by using the traffic scheduler, the application usage request to a reserved service cluster, to run, by the reserved service cluster, a reserved instance matching the application usage request; where the non-idle state indication is used to indicate that the scalable service cluster currently has no idle and usable created instance.

Abstract: The present disclosure provides a method, an apparatus, a computer device and a storage medium of request processing, where the method comprises: obtaining an application usage request; forwarding, by using a traffic scheduler, the application usage request to a scalable service cluster; the scalable service cluster being used to run a created instance matching various application usage requests; and in response to receiving a non-idle state indication fed back by the scalable service cluster, forwarding, by using the traffic scheduler, the application usage request to a reserved service cluster, to run, by the reserved service cluster, a reserved instance matching the application usage request; where the non-idle state indication is used to indicate that the scalable service cluster currently has no idle and usable created instance.

Abstract: In the technical field of plant medicines, disclosed is the application of aloesin in the preparation of products for preventing or treating obesity. Research has found that aloesin can inhibit lipid accumulation, increase the expression of browning genes UCP1 and PRDM16 and transcription factor C-EBPa, increase the expression and release of specific factor adiponectin, and inhibit the release of non-specific factor IL-1?, indicating that aloesin can mediate the browning of 3T3-L1 adipocytes, and aloesin can be used to prepare products for preventing or treating obesity.

Abstract: Disclosed is a 5-methylchromone and the preparation method and application thereof, the 5-methylchromone has the following structure: wherein R1 and R2 are alkyl groups. The substituted chromone has the biological activity of inhibiting tyrosinase. The preparation method uses 3,5-dihydroxytoluene as a raw material, and synthesis of chromones substituted with different groups at 2-C through acylation, esterification, rearrangement and cyclization reactions, etc. The 5-methylchromone is a completely new compound in condition that R1 is —CH2CH2CH3, and R2 is —CH2CH3, or that R1 is —C(CH3)3, and R2 is H. All the compounds have obvious inhibitory activity against tyrosinase, and can be used to prepare tyrosinase inhibitors or whitening agents.