Abstract: An inflatable mattress with a detachably-fastened quilt, including an inflatable mattress body, a quilt body and a first fastening mechanism. The quilt body is detachably fixed to an upper surface of the inflatable mattress body through the first fastening mechanism to cover the upper surface. An end of the quilt body closing to user’s head is provided with two protruding portions, and a trough area is provided between the two protruding portions to expose user’s head. The inflatable mattress body includes a main support cushion and an auxiliary cushion stackedly arranged, which are each provided with a valve to be independently inflated and deflated. The inflatable mattress further includes a windproof cover with a second fastening mechanism and a deployable support structure. The windproof cover is detachably connected to an edge of an end of the inflatable mattress body closing to the user’s head through the second fastening mechanism.