Patents by Inventor Jurg Gysin

Jurg Gysin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of the domain of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) that mediates adhesion to chondroitin sulfate A
    Patent number: 6855323
    Abstract: The present invention relates to the discovery of a var gene and corresponding protein that modulates adhesion of parasitized red blood cells to chondroitin sulfate A. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: February 15, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Artur Scherf, Louis H. Miller, Benoit Gamain, Dror I. Baruch, Pierre Buffet, Christine Scheidig, Jurg Gysin, Bruno Pouvelle, Nobutaka Fujii, Joseph Smith
  • Identification of the domain of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) that mediates adhesion to chondroitin sulfate A
    Publication number: 20040062769
    Abstract: The present invention relates to the discovery of a var gene and corresponding protein that modulates adhesion of parasitized red blood cells to chondroitin sulfate A. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
    Type: Application
    Filed: February 21, 2002
    Publication date: April 1, 2004
    Inventors: Arthur Scherf, Louis H. Miller, Benoit Gamain, Dror I. Baruch, Pierre Buffet, Christine Scheidig, Jurg Gysin, Bruno Pouvelle, Nobutaka Fujii, Joseph Smith
  • Conformational antigens and antibodies recognizing said antigens, a process for the efficient generation of monoclonal antibodies to native or conformational antigens expressed or carried by eukaryotic cells, a process for the selection of conformational antigens, use of monoclonal antibodies for therapeutical, diagnostic or vaccine applications
    Publication number: 20020164652
    Abstract: Conformational antigens and antibodies recognizing said antigens, a process for the efficient generation of monoclonal antibodies to native or conformational antigens expressed or carried by eukaryotic cells. A process for the selection of conformational antigens, use of monoclonal antibodies for therapeutical, diagnostic or vaccine applications.
    Type: Application
    Filed: February 25, 2002
    Publication date: November 7, 2002
    Inventors: Jurg Gysin, Artur Scherf
  • Process for preparing a vaccine against malaria
    Patent number: 5229110
    Abstract: A process for preparing a vaccine against malaria comprising at least one polypeptide extracted from a schizont form of a strain of Plasmodium containing polypeptides antigenic to malaria. The polypeptides are recognized by immunoglobulin from a Saimiri Sciureus monkey resistant to the strain. The process includes the steps of:(a) treating a preparation of a strain of Plasmodium with a solution of a detergent which is able to separate the cellular structures from the parasite proteinic constituents;(b) recovering from the treated preparation, a polypeptide fraction having intact polypeptides of molecular weight ranging from about 70,000-85,000 or 90,000-120,000. The polypeptide fraction induces, in a first splenectomized Saimiri Sciureus monkey, a protective antibody against such strain, the polypeptides being recognized by immunoglobulin from a second Saimiri Sciureus monkey resistant to the strain.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: July 20, 1993
    Assignee: Institut Pasteur
    Inventors: Philippe DuBois, Jean P. Dedet, Thierry G. Fandeur, Serge Pauillac, Christian P. Roussilhon, Luiz P. Pereira de Silva, Jurg Gysin
  • Siderophores as antiparasitic agents
    Patent number: 5192807
    Abstract: Antiparasitic agents constituted by a siderophore substance including at least one hydroxamate group, at least one peptide bond, and having a molecular weight of less than 1,000 D, e.g. aerobactin. A method of isolating antiparasitic agents by purification from the supernatant of a culture of an appropriate bacteria such as pathogenic enterobacteria applicable as antiparasitic agents, in particular as antimalarial agents.
    Type: Grant
    Filed: September 19, 1991
    Date of Patent: March 9, 1993
    Assignee: Institut Pasteur
    Inventors: Jurg Gysin, Yves Crenn, Luiz Pereira da Silva, Catherine Breton
  • Polypeptidic fractions inducing protective antibodies against malaria parasites and immunogenic compositions
    Patent number: 5032397
    Abstract: An immunogenic composition for a vaccine against human malaria. The composition contains one or more polypeptides that can be extracted from a schizont form of a human-malaria parasite such as a Plasmodium falciparum. The polypeptides have a molecular weight of 40,000 to 140,000, and they react with protective antibodies which come from a monkey resistant to the malaria parasite and which can, by in vivo transfer to a monkey sensitive to the parasite, protect the sensitive monkey against the parasite.
    Type: Grant
    Filed: July 10, 1989
    Date of Patent: July 16, 1991
    Assignee: Institut Pasteur
    Inventors: Philippe Dubois, Jean P. Dedet, Thierry G. Fandeur, Serge E. Pauillac, Christian P. Roussilhon, Luiz H. Pereira Da Silav, Jurg Gysin